AUTHOR=Batzenschlager Morgane , HERZOG Etienne , Houlné Guy , Schmit Anne-Catherine , Chabouté Marie-Edith 

TITLE=GIP/MZT1 proteins orchestrate nuclear shaping

JOURNAL=Frontiers in Plant Science

VOLUME=Volume 5 - 2014

YEAR=2014

URL=https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2014.00029

DOI=10.3389/fpls.2014.00029

ISSN=1664-462X

ABSTRACT=The functional organization of the nuclear envelope (NE) is only just emerging in plants with the recent characterization of NE protein complexes and their molecular links to the actin cytoskeleton. The NE also plays a role in microtubule (MT) nucleation by recruiting γ-Tubulin Complexes (γ-TuCs) which contribute to the establishment of a robust mitotic spindle. γ-tubulin Complex Protein 3 (GCP3)-interacting proteins (GIPs) have been identified recently as integral components of γ-TuCs. GIPs have been conserved throughout evolution and are also named MZT1 (mitotic-spindle organizing protein 1). This review focuses on recent data investigating the role of GIP/MZT1 at the NE, including insights from the study of GIP partners. It also uncovers new functions for GIP/MZT1 during interphase and highlights a current view of NE-associated components which are critical for nuclear shaping during both cell division and differentiation.<br/><br/>