AUTHOR=Pljevljakušić Dejan , Bigović Dubravka , Janković Teodora , Jelačić Slavica , Šavikin Katarina TITLE=Sandy Everlasting (Helichrysum arenarium (L.) Moench): Botanical, Chemical and Biological Properties JOURNAL=Frontiers in Plant Science VOLUME=Volume 9 - 2018 YEAR=2018 URL=https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2018.01123 DOI=10.3389/fpls.2018.01123 ISSN=1664-462X ABSTRACT=Sandy everlasting [Helichrysum arenarium (L.) Moench] is herbaceous perennial plant belonging to Asteraceae family and it is native to Europe, Central Asia, and China. Its flowers have a long tradition in European ethnomedicine as a cholagogue, choleretic, hepatoprotective and detoxifying herbal drug. The flowers are rich in phenolic compounds including flavonoids, chalcones, phenolic acids, coumarins, and pyrones. Apart from polyphenols, other compounds such as sterols, lignans, and glycosides of aromatic compounds have been also isolated from H. arenarium. The majority of authors confirm that the most important group of compounds responsible for biological activities is flavonoids. Moreover, significant activities of naringenin, one of the main flavonoids of H. arenarium, were reported. On the other hand, there are no clinical data about testing the extracts or preparations based on H. arenarium. Although the sandy everlasting is very interesting for the pharmaceutical industry, and are classified as endangered species in a number of European countries, very few data about its cultivation are available in the literature.