AUTHOR=Desmedt Willem , Mangelinckx Sven , Kyndt Tina , Vanholme Bartel TITLE=A Phytochemical Perspective on Plant Defense Against Nematodes JOURNAL=Frontiers in Plant Science VOLUME=Volume 11 - 2020 YEAR=2020 URL=https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2020.602079 DOI=10.3389/fpls.2020.602079 ISSN=1664-462X ABSTRACT=Plant-parasitic nematodes are among the most devastating plant pests. To defend themselves against nematode attack, plants possess sophisticated multi-layered immune systems involving various mechanisms. One such mechanism is the production of small molecules with anti-nematode properties, either constitutively or induced upon nematode infection. This review provides an overview of known anti-nematode phytochemicals, of strategies for their identification and of ways in which knowledge of these metabolites could advance agriculture and crop protection.