AUTHOR=Ai Likun , Fu Shiqi , Li Yong , Zuo Mei , Huang Wen , Huang Jian , Jin Zhichao , Chen Yang 

TITLE=Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues

JOURNAL=Frontiers in Plant Science

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2022.1102411

DOI=10.3389/fpls.2022.1102411

ISSN=1664-462X

ABSTRACT=Botanical pesticides are one of the sources of third-generation pesticides, which have received much attention at home and abroad in recent years due to their degradable and pollution-free advantages in nature. Our group explored a concise approach toward synthesizing a series of novel L-pyroglutamic acid analogs from L-hydroxyproline. Furthermore, this paper investigated antifungal activity of these sulfonyl ester derivatives on hydroxyl against Pyricularia oryzae, Fusarium graminearum, Alternaria brassicae, Valsa mali, and Altenaria alternariae. Bioassay studies showed that most compounds show moderate antifungal activity. For instance, C08a and C08l showed the best activity against Fusarium graminearum. This study suggests that compound C08n could be used as a potential lead compound to control Fusarium graminearum.