AUTHOR=Li Jian , Gao Yuan , Li Zheng , Zhang Weijian , Yu Weilin , Hu Yating , Liu He , Li Changtian TITLE=Multi-stage bidirectional informed-RRT * plant protection UAV path planning method based on A * algorithm domain guidance JOURNAL=Frontiers in Plant Science VOLUME=Volume 16 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2025.1650007 DOI=10.3389/fpls.2025.1650007 ISSN=1664-462X ABSTRACT=Traditional path planning algorithms often face problems such as local optimum traps and low monitoring efficiency in agricultural UAV operations, making it difficult to meet the operational requirements of complex environments in modern precision agriculture. Therefore, there is an urgent need to develop an intelligent path planning algorithm. To address this issue, this study proposes an improved Informed-RRT* path planning algorithm guided by domain-partitioned A* algorithm. The proposed algorithm employs a multi-level decomposition strategy to intelligently divide complex paths into a sequence of key sub-segments, and uses an adaptive node density allocation mechanism to dynamically respond to changes in path complexity. Finally, a dual-layer optimization framework is constructed by combining elliptical heuristic sampling with dynamic weight adjustment. Complex maps are constructed in simulation to evaluate the algorithm’s performance under varying obstacle densities. Experimental results show that, compared to traditional RRT* and its improved variants, the proposed algorithm reduces computation time by 56.3%–92.5% and shortens path length by 0.42%–8.5%, while also demonstrating superior path smoothness and feasibility, as well as a more balanced distribution of search nodes. Comprehensive analysis indicates that the A*-MSRRT* (A*-Guided Multi-stage Bidirectional Informed-RRT*) algorithm has strong potential for application in complex agricultural environments.