AUTHOR=Szklarczyk Arek , Conant Katherine TITLE=Matrix Metalloproteinases, Synaptic Injury, and Multiple Sclerosis JOURNAL=Frontiers in Psychiatry VOLUME=1 YEAR=2010 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2010.00130 DOI=10.3389/fpsyt.2010.00130 ISSN=1664-0640 ABSTRACT=

Multiple sclerosis (MS) is a disease of the central nervous system in which immune mediated damage to myelin is characteristic. For an overview of this condition and its pathophysiology, please refer to one of many excellent published reviews (Sorensen and Ransohoff, 1998; Weiner, 2009). To follow, is a discussion focused on the possibility that synaptic injury occurs in at least a subset of patients, and that matrix metalloproteinases (MMPs) play a role in such.