AUTHOR=Moretti davide v., Frisoni giovanni b., Binetti giuliano , Zanetti orazio 

TITLE=Anatomical Substrate and Scalp EEG Markers are Correlated in Subjects with Cognitive Impairment and Alzheimer's Disease

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 1 - 2010

YEAR=2011

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2010.00152

DOI=10.3389/fpsyt.2010.00152

ISSN=1664-0640

ABSTRACT=Dementia is a syndromic diagnosis, encompassing various stage of severity and different anatomo-physiological substrates. The hippocampus is one of the first and most affected brain regions affected by both Alzheimer’s disease (AD) and mild cognitive impairment (MCI). 
Morevoer, cronic cerebrovascular disease (CVD) is one of the major risk factor for developing dementia. Recent studies have demonstrated different relationship between the anatomical substrate and scalp electroencephalography (EEG) markers. Indeed, modifications of EEG rhythmicity is not proportional to the hippocampal atrophy, whereas changes in  EEG activity are directly proportional to the load of subcortical CVD.
Quantitative EEG have been demonstrated a reliable tool in identifying specific patterns in dementia research (Coburn et al., 2006; John and Prichep, 2006). The computation of the spectral power and the analysis of the functional coupling of brain areas, through linear coherence, are two of the most known processing methods in EEG research. Two specific EEG markers, theta/gamma and alpha3/alpha2 frequency ratio have been reliable associated to the atrophy of amygdalo-hippocampal complex. Moreover, theta/gamma ratio has been related to MCI conversion i