AUTHOR=Kromer Robert , Serbecic Nermin , Hausner Lucrezia , Aboul-Enein Fahmy , Froelich Lutz , Beutelspacher Sven 

TITLE=Detection of Retinal Nerve Fiber Layer Defects in Alzheimer’s Disease Using SD-OCT

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 5 - 2014

YEAR=2014

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2014.00022

DOI=10.3389/fpsyt.2014.00022

ISSN=1664-0640

ABSTRACT=Introduction:<br/>To examine the clinical value of spectral-domain optical coherence tomography (Spectralis OCT) to detect retinal nerve fibre layer defects in patients with clinically defined Alzheimer‘s disease (AD).<br/><br/>Material and Methods:<br/>This cross-sectional study included 22 patients with AD (mean age: 75.9 ± 6.1 years) and 22 healthy age- and sex-matched controls. Neuro-ophthalmologic examinations and a series of high-resolution OCT examinations of the peripapillary retinal nerve fibre layer (RNFL) thickness using the Spectralis 3.5-mm circle scan protocol with ART-Modus and eye tracking were obtained, and compared to age- and sex-matched healthy control subjects.<br/><br/>Results:<br/>Patients with AD showed a significant decrease in RNFL thickness in the nasal superior sector compared to the control group (101.0 ± 18.18 µm vs. 122.8 ± 28.08 µm; p