AUTHOR=de Beaurepaire Renaud 

TITLE=The Use of Very High-Doses of Baclofen for the Treatment of Alcohol-Dependence: A Case Series

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 5 - 2014

YEAR=2014

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2014.00143

DOI=10.3389/fpsyt.2014.00143

ISSN=1664-0640

ABSTRACT=Baclofen, particularly high-dose baclofen, has recently emerged as a treatment of major interest for alcohol-dependence. However, baclofen has many potentially dangerous side effects, and the maximal dose of baclofen that may be used is a matter of discussion. Here, the author analyses the medical charts of the last 100 patients seen in his clinic, 17 of whom have been taking a very high dose of baclofen, that is to say, more than 300mg per day. The analysis of the charts shows that the very high doses baclofen were justified in almost all the cases. Side effects are analyzed.