AUTHOR=Guarnieri Regina V. , Ribeiro Rafaela L. , de Souza Altay A. Lino , Galduróz José Carlos F. , Covolan Luciene , Bueno Orlando F. A. 

TITLE=Effects of Sulpiride on True and False Memories of Thematically Related Pictures and Associated Words in Healthy Volunteers

JOURNAL=Frontiers in Psychiatry

VOLUME=7

YEAR=2016

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2016.00028

DOI=10.3389/fpsyt.2016.00028

ISSN=1664-0640

ABSTRACT=<p>Episodic memory, working memory, emotional memory, and attention are subject to dopaminergic modulation. However, the potential role of dopamine on the generation of false memories is unknown. This study defined the role of the dopamine D<sub>2</sub> receptor on true and false recognition memories. Twenty-four young, healthy volunteers ingested a single dose of placebo or 400 mg oral sulpiride, a dopamine D<sub>2</sub>-receptor antagonist, just before starting the recognition memory task in a randomized, double-blind, and placebo-controlled trial. The sulpiride group presented more false recognitions during visual and verbal processing than the placebo group, although both groups had the same indices of true memory. These findings demonstrate that dopamine D<sub>2</sub> receptors blockade in healthy volunteers can specifically increase the rate of false recognitions. The findings fit well the two-process view of causes of false memories, the activation/monitoring failures model.</p>