AUTHOR=Mossaheb Nilufar , Kaufmann Rainer M. , Schlögelhofer Monika , Aninilkumparambil Thushara , Himmelbauer Claudia , Gold Anna , Zehetmayer Sonja , Hoffmann Holger , Traue Harald C. , Aschauer Harald 

TITLE=The Impact of Sex Differences on Odor Identification and Facial Affect Recognition in Patients with Schizophrenia Spectrum Disorders

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2018.00009

DOI=10.3389/fpsyt.2018.00009

ISSN=1664-0640

ABSTRACT=Background: Social interactive functions, such as facial emotion recognition and smell identification have been shown to differ between women and men. However little is known, how these differences are mirrored in patients with schizophrenia and how these abilities interact with each other and with other clinical variables in patients vs. healthy controls. 
Methods: Standardized instruments were used to assess facial emotion recognition (FEEL) and smell identification (UPSIT) in 51 patients with schizophrenia –spectrum disorders and 79 healthy controls; furthermore, working memory functions and clinical variables were assessed. 
Results: Both in the univariate and the multivariate results, illness showed a significant influence on UPSIT and FEEL. The inclusion of age and working memory in the MANOVA resulted in a differential effect with sex and working memory as remaining significant factors.  Duration of illness was correlated with both emotion recognition and smell identification in men only, whereas immediate general psychopathology and negative symptoms was associated with emotion recognition only in women. 
Conclusion: Being affected by schizophrenia-spectrum disorder impacts one’s ability to correctly recognize facial affects and identify odors. Converging evidence suggests a link between the investigated basic and social cognitive abilities in patients with schizophrenia-spectrum disorders with a strong contribution of working memory and differential effects of modulators in women vs. men.