AUTHOR=Stanikova Daniela , Luck Tobias , Pabst Alexander , Bae Yoon Ju , Hinz Andreas , Glaesmer Heide , Stanik Juraj , Sacher Julia , Engel Christoph , Enzenbach Cornelia , Wirkner Kerstin , Ceglarek Uta , Thiery Joachim , Kratzsch Juergen , Riedel-Heller Steffi G. TITLE=Associations Between Anxiety, Body Mass Index, and Sex Hormones in Women JOURNAL=Frontiers in Psychiatry VOLUME=Volume 10 - 2019 YEAR=2019 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00479 DOI=10.3389/fpsyt.2019.00479 ISSN=1664-0640 ABSTRACT= Background. Several studies have shown a positive association between anxiety and obesity, particularly in women. We aimed to study whether sex hormone alterations related to obesity might play a role in this association. Patients and methods. Data for this study were obtained from a population-based cohort study (the LIFE-Adult-Study). A total of 3124 adult women (970 premenopausal and 2154 postmenopausal), were included into analyses. The anxiety symptomatology was assessed using the GAD-7 questionnaire (cut off ≥ 10 points). Sex hormones were measured from fasting serum samples. Results. We did not find significant differences in anxiety prevalence in premenopausal obese women compared to normal-weight controls (4.8% vs 5.5%). Both obesity and anxiety symptomatology were separately associated with the same sex hormone alteration in premenopausal women: higher total testosterone level (0.97±0.50 in obese vs. 0.86±0.49 nmol/L in normal-weight women, p=0.026 and 1.04±0.59 in women with vs. 0.88±0.49 nmol/L in women without anxiety symptomatology, p=0.023) . However, women with anxiety symptomatology had non-significantly higher estradiol levels compared to women without anxiety symptomatology (548.0±507.6 vs. 426.2±474.0 pmol/L), whereas obesity was associated with lower estradiol levels compared to normal-weight group (332.7±386.5 vs. 470.8±616.0 pmol/L). Women with anxiety symptomatology had also significantly higher testosterone and estradiol composition (p=0.006). No associations of sex hormone levels and BMI with anxiety symptomatology in postmenopausal women were found. Conclusions. Although both obesity and anxiety symptomatology were separately associated with higher testosterone level, there was an opposite impact of anxiety and obesity on estradiol levels in premenopausal women. We did not find an evidence that the sex hormone alterations related to obesity are playing a significant role in anxiety symptomatology in premenopausal women. This could be the explanation, why we did not find an association between obesity and anxiety. In postmenopausal women seem to work other mechanisms compared to premenopausal group.