AUTHOR=Son Sang Joon , Park Bumhee , Choi Jin Wook , Roh Hyun Woong , Kim Na-Rae , Sin Jae Eun , Kim Haena , Lim Hyun Kook , Hong Chang Hyung 

TITLE=Psychological Resilience Enhances the Orbitofrontal Network in the Elderly With Mild Cognitive Impairment

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 10 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00615

DOI=10.3389/fpsyt.2019.00615

ISSN=1664-0640

ABSTRACT=Background: It has been suggested that maintaining the efficient organization of the brain’s functional connectivity (FC) supports neuroflexibility under neurogenerative stress. This study examined psychological resilience related FC in one hundred twelve older adults with mild cognitive impairment.
Methods: Using a resting-state functional magnetic resonance imaging (fMRI) approach, we investigated reorganization of the orbitofrontal gyrus (OFG)/ amygdala (AMG)/ hippocampus (HP)/ parahippocampal gyrus (PHG) FC according to the different level of resilience scale. 
Results: Compared with the low resilient group, the high resilient group had greater connectivity strengths between the left inferior OFG and right superior OFG (P<0.05, Bonferroni corrected), between the right inferior OFG and left PHG (P<0.05, Bonferroni corrected), and between the right middle OFG and left PHG (False Discovery Rate<0.05). 
Conclusion: Psychological resilience may be associated with enhancement of the orbitofrontal network in the elderly with MCI.