AUTHOR=Kumar Ashutosh , Pareek Vikas , Singh Himanshu N. , Faiq Muneeb A. , Narayan Ravi K. , Raza Khursheed , Kumar Pavan 

TITLE=Altered Expression of a Unique Set of Genes Reveals Complex Etiology of Schizophrenia

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 10 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00906

DOI=10.3389/fpsyt.2019.00906

ISSN=1664-0640

ABSTRACT=Background: The etiology of schizophrenia is extensively debated, and multiple factors have been contended to be involved. A panoramic view of the contributing factors in a genome-wide study can be an effective strategy to provide a comprehensive understanding of its causality.
Materials and Methods: GSE53987 dataset downloaded from GEO-database, which comprised mRNA expression data of post-mortem brain tissue across three regions from control (C) and age-matched subjects (T) of schizophrenia (N= Hippocampus (HIP): C-15, T-18, Prefrontal cortex (PFC): C-15, T-19, Associative striatum (STR): C-18, T-18). Bio-conductor -affy- package used to compute mRNA expression, and further t-test applied to investigate differential gene expression. The analysis of the derived genes performed using the PANTHER Classification System and NCBI database. Further, a protein interactome analysis of the derived gene set was performed using STRING v10 database (https://string-db.org/).
Results: A set of 40 genes showed significantly altered (p<0.01) expression across all three brain regions. The analyses unraveled genes implicated in biological processes and events, and molecular pathways relating basic neuronal functions. 
Conclusions: The aberrant expression of genes maintaining basic cell machinery explains compromised neuronal processing in SCZ.