AUTHOR=Li Xiaotong , Su Hang , Zhong Na , Chen Tianzhen , Du Jiang , Xiao Ke , Xu Ding , Song Weidong , Jiang Haifeng , Zhao Min 

TITLE=Aberrant Resting-State Cerebellar-Cerebral Functional Connectivity in Methamphetamine-Dependent Individuals After Six Months Abstinence

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2020.00191

DOI=10.3389/fpsyt.2020.00191

ISSN=1664-0640

ABSTRACT=Background: Although structural and functional alterations in cerebellum have been consistently reported in the addiction literatures, evidence implicating the resting-state cerebellar-cerebral functional connectivity in methamphetamine (MA) use disorder still remains limited.
Methods: Resting-state functional magnetic resonance imaging (fMRI) scans were obtained from 34 MA dependent individuals with 6 months abstinence and 31 healthy controls (well matched for age, gender and education) in this study. Seed-based functional connectivity analysis was employed to investigate the differences in cerebellar-cerebral functional connectivity between two groups. The correlations between significant functional connectivity and each clinical characteristic were also explored.
Results: Compared to healthy controls, MA dependent individuals showed disrupted functional connectivity between the cerebellum and several cerebral functional networks, including the default mode network (DMN), affective-limbic and sensorimotor networks. Within the MA group, increased functional connectivity of the right cerebellar lobule VI-precuneus coupling was negatively correlated with addiction severity.
Conclusion: The present study suggests that cerebellar dysfunction, in particular aberrant cerebellar-cerebral functional connectivity, might involve in neurobiological mechanism of MA use disorder, which supply a potential target for therapeutic interventions in the future.