AUTHOR=Dueck Alexander , Reis Olaf , Bastian Manuela , van Treeck Lucas , Weirich Steffen , Haessler Frank , Fiedler Andreas , Koelch Michael , Berger Christoph 

TITLE=Feasibility of a Complex Setting for Assessing Sleep and Circadian Rhythmicity in a Fragile X Cohort

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2020.00361

DOI=10.3389/fpsyt.2020.00361

ISSN=1664-0640

ABSTRACT=Introduction: Sleep, circadian rhythms, (mental) health and development are assumed to be intertwined, but are hard to measure in Fragile X individuals. As sleep and circadian parameters need to be observed in complex settings, the feasibility of measurements for people with Fragile X was tested. Findings from this pilot study can be used to estimate sample sizes for studies to come. 
Methods and sample: 9 individuals (male and female) with full mutation of the FMR1 gene were integrated in the study and underwent the complex setting including actigraphy, sleep log, 24 h saliva sampling to examine profiles of melatonin and cortisol, and polysomnography.
Results:  n=7 PSGs, n=8 sleep logs, n=8 saliva profiles, n=7 actigraphy profiles and n=6 complete data sets (mean age 14,87 years (SD 4,12), mean BMI 25,90 (SD 4,44)) were collected. No investigation was interrupted or cancelled during procedure.
Discussion: Each investigation and the setting in total were tolerated well by participants and caring systems (parents or care givers). Procedures were adapted to the needs of the participants. 
Conclusion: All its components and the setting in total are absolutely feasible in the specific population of FXS individuals.