AUTHOR=Wilkowska Alina , Szałach Łukasz , Słupski Jakub , Wielewicka Aleksandra , Czarnota Małgorzata , Gałuszko-Węgielnik Maria , Wiglusz Mariusz S. , Cubała Wiesław J. 

TITLE=Affective Switch Associated With Oral, Low Dose Ketamine Treatment in a Patient With Treatment Resistant Bipolar I Depression. Case Report and Literature Review

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2020.00516

DOI=10.3389/fpsyt.2020.00516

ISSN=1664-0640

ABSTRACT=There is a growing evidence for the rapid and robust anti-depressive effect of ketamine in unipolar and bipolar treatment resistant depression although evidence for the risk of affective switch is still limited. This case presents bipolar I disorder patient with treatment resistant depressive episode experiencing a switch to manic episode with mixed features shortly after receiving 8 subanaesthetic doses of oral ketamine as an add-on treatment preceded by two-day period of manic symptoms.