AUTHOR=Tomitaka Shinichiro , Kawasaki Yohei , Ide Kazuki , Akutagawa Maiko , Ono Yutaka , Furukawa Toshiaki A. 

TITLE=Age-Related Changes in Item Responses to the Patient Health Questionnaire-9: Evidence From the National Health and Nutrition Examination Survey

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2020.00723

DOI=10.3389/fpsyt.2020.00723

ISSN=1664-0640

ABSTRACT=Background: Epidemiological studies have shown that total scores in depression screening scales change with age, but the mechanism underlying these age-related changes remains unclear. Previous research has indicated that item responses in depression screening scales exhibit characteristic distributions in the general population. We analyzed Patient Health Questionnaire-9 (PHQ-9) data from a representative survey conducted in the USA, to determine how the response pattern for each item changed with age and whether the pattern of responses contributed to age-related changes in total scores.
Methods: We analyzed PHQ-9 data for 17,274 participants in the 2011‒2016 National Health and Nutrition Examination Survey. The PHQ-9 allows respondents to self-rate the frequency of depressive symptoms using a four-point scale ranging from “not at all” to “nearly every day.” 
Results: The lines for all nine item responses followed the same characteristic pattern across all age groups, which was marked by intersection at a single point between “not at all” and “several days” and parallel patterns between “several days” and “nearly every day” on a logarithmic scale. The probability of “nearly every day” showed a reverse U-shaped pattern, in that it was low from 12–29 years, increased during 30–50 years, and then decreased at ≥60 years. The age-related change in the probability of a response of “nearly every day” coincided with the trajectory of the PHQ-9 total scores.
Conclusions: This study demonstrated that item responses for the PHQ-9 followed  a similar mathematical pattern across the adult lifespan. Moreover, our findings suggested that the probability of a response of “nearly every day” played an important role in age-related changes in PHQ-9 total scores across adulthood.