AUTHOR=Shen Jun , Shenkar Dina , An Li , Tomar Jyoti Singh 

TITLE=Local and Interregional Neurochemical Associations Measured by Magnetic Resonance Spectroscopy for Studying Brain Functions and Psychiatric Disorders

JOURNAL=Frontiers in Psychiatry

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2020.00802

DOI=10.3389/fpsyt.2020.00802

ISSN=1664-0640

ABSTRACT=<p>Magnetic resonance spectroscopy (MRS) studies have found significant correlations among neurometabolites (<italic>e.g.</italic>, between glutamate and GABA) across individual subjects and altered correlations in neuropsychiatric disorders. In this article, we discuss neurochemical associations among several major neurometabolites which underpin these observations by MRS. We also illustrate the role of spectral editing in eliminating unwanted correlations caused by spectral overlapping. Finally, we describe the prospects of mapping macroscopic neurochemical associations across the brain and characterizing excitation–inhibition balance of neural networks using glutamate- and GABA-editing MRS imaging.</p>