AUTHOR=He Li , Liao Yanhui , Wu Qiuxia , Liu Tieqiao 

TITLE=Association Between Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Methamphetamine Use Disorder: A Meta-Analysis

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2020.585852

DOI=10.3389/fpsyt.2020.585852

ISSN=1664-0640

ABSTRACT=Background: Several studies had examined the association between BDNF Val66Met polymorphism and methamphetamine (METH) abuse, whereas the results were conflicting. The aim of this study was to conduct a meta‐analysis to achieve a pooled effect size of the association between BDNF Val66Met polymorphism and METH use disorder.
Methods: Literature searches were conducted in PubMed, EMBASE, and Cochrane Library up to 2020 July. All relevant studies on the relationship of BDNF Val66Met polymorphism and METH abuse were retrieved. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated in dominant, recessive, co-dominant and allele model to appraise the association. 
Results: Seven case-control studies with a total of 2204 subjects (956 METH-dependent cases and 1248 healthy controls) were included in this meta-analysis. The results showed a significant correlation between BDNF Val66Met polymorphism and METH abuse in overall population under different genetic models. However, subgroup analysis indicated the association only existed in Han Chinese but not in other Asian population.
Conclusion: Although the current data indicated BDNF Val66Met polymorphism might be a potential genetic factor for METH use disorder, more researches are needed to prove its role in different population.