AUTHOR=Rancans Elmars , Dombi Zsófia Borbála , Barabássy Ágota 

TITLE=Dosing Cariprazine Within and Beyond Clinical Trials: Recommendations for the Treatment of Schizophrenia

JOURNAL=Frontiers in Psychiatry

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2021.770234

DOI=10.3389/fpsyt.2021.770234

ISSN=1664-0640

ABSTRACT=<p>Although the optimal dosing of an antipsychotic medication is known to be essential in the long-term management of schizophrenia, in case of novel drugs such as cariprazine, determining the right dosing strategy is not that simple. Without decades of experience with a particular compound, evidence regarding dosing and titration comes primarily from double-blind, placebo controlled clinical trials that are not necessarily mirroring the real-life experiences of doctors. Via summarizing data from both clinical data (<italic>n</italic> = 3275) and real-world evidence (observational study <italic>n</italic> = 116, case studies <italic>n</italic> = 29), this perspective paper aims to shed a light on the appropriate dosing strategies of cariprazine from treatment initiation through switching strategies to concomitant medications.</p>