AUTHOR=Avalos Lyndsay A. , Nance Nerissa , Zhu Yeyi , Croen Lisa A. , Young-Wolff Kelly C. , Zerbo Ousseny , Hedderson Monique M. , Ferrara Assiamira , Ames Jennifer L. , Badon Sylvia E. TITLE=Contributions of COVID-19 Pandemic-Related Stressors to Racial and Ethnic Disparities in Mental Health During Pregnancy JOURNAL=Frontiers in Psychiatry VOLUME=Volume 13 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.837659 DOI=10.3389/fpsyt.2022.837659 ISSN=1664-0640 ABSTRACT=Background: This study aimed to identify racial and ethnic disparities in prenatal mental health and identify COVID-19 pandemic-related health/healthcare and economic contributors to these disparities, using an established framework for disparity investigation. Methods: This cross-sectional study includes 10,930 pregnant individuals at Kaiser Permanente Northern California who completed an online survey between June 22, 2020 and April 28, 2021 on COVID-19-pandemic-related health/healthcare and economic stressors, depression and anxiety. Self-reported race and ethnicity was extracted from electronic health records. Weighted analyses were used to evaluate the association between racial and ethnic category and prenatal depression and anxiety; the prevalence of each stressor by race and ethnicity; and the relationship between each stressor and prenatal depression and anxiety in each racial and ethnic category. Results: The sample was 22% Asian, 3% Black, 20% Hispanic, 5% Other/Multiracial/Unknown, and 49% White. Compared to White individuals, Black and Hispanic individuals had a higher prevalence of prenatal depression (aPR:1.85, 95%CI:1.45, 2.35 and aPR:1.17, 95%CI:1.00,1.37, respectively) and anxiety (aPR:1.71, 95%CI:1.34, 2.18 and aPR:1.10, 95%CI:0.94, 1.29, respectively). Compared to White individuals, Black and Hispanic individuals had a higher prevalence of moderate/severe distress due to changes in prenatal care (24% vs. 34% and 31%), and food insecurity (9% vs. 31% and 24%). Among Black and Hispanic individuals, distress due to changes in prenatal care was associated with a greater prevalence of prenatal depression (aPR:2.27, 95% CI:1.41, 3.64 and aPR: 2.76, 95%CI:2.12, 3.58, respectively) and prenatal anxiety (aPR:3.00, 95%CI:1.85, 4.84 and aPR:2.82, 95% CI: 2.15, 3.71, respectively). Additionally, among Hispanic individuals, high-risk employment and food insecurity was associated with a greater prevalence of prenatal depression and anxiety. Conclusions: This study identified racial and ethnic disparities in mental health for pregnant Black and Hispanic individuals. Distress due to prenatal care changes contributed to the observed disparities in prenatal depression and anxiety for Black and Hispanic individuals and food insecurity additionally contributed to the observed disparities for Hispanic individuals. Addressing distress due to changes to prenatal care and food insecurity specifically in Black and Hispanic individuals may help reduce the high burden of poor mental health and reduce observed disparities in these communities.