AUTHOR=Grent-’t-Jong Tineke , Gajwani Ruchika , Gross Joachim , Gumley Andrew I. , Lawrie Stephen M. , Schwannauer Matthias , Schultze-Lutter Frauke , Williams Stephen R. , Uhlhaas Peter J. TITLE=MR-Spectroscopy of GABA and Glutamate/Glutamine Concentrations in Auditory Cortex in Clinical High-Risk for Psychosis Individuals JOURNAL=Frontiers in Psychiatry VOLUME=Volume 13 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.859322 DOI=10.3389/fpsyt.2022.859322 ISSN=1664-0640 ABSTRACT=
Psychosis involves changes in GABAergic and glutamatergic neurotransmission in auditory cortex that could be important for understanding sensory deficits and symptoms of psychosis. However, it is currently unclear whether such deficits are present in participants at clinical high-risk for psychosis (CHR-P) and whether they are associated with clinical outcomes. Magnetic Resonance Spectroscopy (MEGAPRESS, 1H-MRS at 3 Tesla) was used to estimate GABA, glutamate, and glutamate-plus-glutamine (Glx) levels in auditory cortex in a large sample of CHR-P (