AUTHOR=Zhang Ting , Guo Lin , Li Rui , Wang Fei , Yang Wen-mao , Yang Jia-bin , Cui Zhi-quan , Zhou Cui-hong , Chen Yi-huan , Yu Huan , Peng Zheng-wu , Tan Qing-rong 

TITLE=Alterations of Plasma Lipids in Adult Women With Major Depressive Disorder and Bipolar Depression

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.927817

DOI=10.3389/fpsyt.2022.927817

ISSN=1664-0640

ABSTRACT=Lipidomics has been established as a pivotal tool for the diagnosis of depression and bipolar disorder. However, the composition analysis of the peripheral lipids regarding adult women with major depressive depression (MDD) or bipolar depression (BPD) as well as the comparison to each other has been poorly addressed. In the present study, plasma samples from age-matched female individuals with MDD (n = 28), BPD (n = 22) and healthy controls (HC, n = 25) were analyzed by comprehensive lipid profiling and quantitative validation based on liquid chromatography-mass spectrometry (LC/MS). We found that the composition of lipids was remarkably changed in the patients with MDD and BPD when compared to HC or compared to each other. Moreover, we identified diagnostic potential biomarkers comprising 20 lipids that can distinguish MDD from HC (AUC = 0.897) and 8 lipids that can distinguish BPD from HC (AUC = 0.784), as well as 13 lipids were identified to distinguish MDD from BPD with moderate reliability (AUC = 0.860). This study provides further understanding of abnormal lipid metabolism in the plasma in adult women with MDD and BPD and may develop lipid classifiers able to effectively discriminate MDD from BPD and HC.