AUTHOR=Zeng Can , Liao SuQun , Pu Weidan 

TITLE=Trait and state-related characteristics of thalamo-cortical circuit disruption in bipolar disorder: a prospective cross-sectional study

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2023.1067819

DOI=10.3389/fpsyt.2023.1067819

ISSN=1664-0640

ABSTRACT=Objective: The purpose of this study is to investigate the shared and distinct thalamic-cortical circuit between bipolar depression and remission, as well as to investigate the trait and state-related characteristics of the abnormal thalamic-cortical circuit in bipolar disorder.
Methods: Resting-state functional magnetic resonance imaging was performed on 38 bipolar
depression patients, 40 bipolar remission patients, and 39 gender-matched healthy controls (rsfMRI). The thalamic subregions were used as seed points to draw the functional connectivity of
the entire brain, and then the shared and distinct thalamic-cortical circuits between bipolar
depression and remission were compared.
Results: When compared to the healthy group, both groups of patients had significantly lower
functional connectivity between the rostral temporal thalamus and the lingual gyrus, the posterior
parietal thalamus, the precuneus/cerebellum, and the occipital thalamus and the precuneus; however, functional connectivity between the premotor thalamus and the superior medial frontal was significantly lower in depression.
Conclusion: This study discovered that both bipolar depression and remission had abnormal
sensorimotor-thalamic functional connectivity, implying that it is a trait-related characteristic of
bipolar disorder; however, the decline in prefrontal-thalamic connectivity exists specifically in
bipolar depression, implying that it is a state-related characteristic of bipolar disorder