AUTHOR=Yang Hong , Yang Kun , Zhang Lu , Yang Ni , Mei Ying-Xiu , Zheng Ya-Li , He Yan , Gong Yan-Ju , Ding Wei-Jun 

TITLE=Acupuncture ameliorates Mobile Phone Addiction with sleep disorders and restores salivary metabolites rhythm

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2023.1106100

DOI=10.3389/fpsyt.2023.1106100

ISSN=1664-0640

ABSTRACT=Mobile phone addiction (MPA) is a novel behavioral addiction resulting in circadian rhythm disorders that severely affect mental and physical health. We aim to detect rhythmic salivary metabolites in MPA with sleep disorder (MPASD) subjects and investigate the effects of acupuncture intervention by Mobile Phone Addiction Tendency Scale (MPATS) and Pittsburgh Sleep Quality Index (PSQI). The salivary samples of MPASD and healthy controls were collected every 4 h intervals for three days. Acupuncture was administered for 7 days to MPASD subjects, then saliva samples were collected again. Salivary metabolomes were analyzed using LC-MS. There were 70 (57.85%) MPA patients and 56 (46.28%) MPASD patients identified among 121 volunteers. The symptoms of MPASD subjects significantly improved after acupuncture intervention. The number of rhythmic saliva metabolites was considerably dropped in MPASD subjects and restored after acupuncture. Representative rhythmic saliva metabolites including melatonin, 2'-deoxyuridine, thymidine, thymidine 3',5'-cyclic monophosphate lost rhythm and restored after acupuncture may be promising MPASD treatment and diagnosis markers. The rhythmic saliva metabolites of healthy controls were mainly enriched in neuroactive ligand-receptor interaction, whereas polyketide sugar unit biosynthesis was mainly enriched in MPASD patients. The study revealed circadian rhythm characteristics of salivary metabolites in MPASD and that acupuncture could ameliorate MPASD by restoring part of the dysrhythmia salivary metabolites.