AUTHOR=Zhao Shuai , Zhang Boyu , Han Yuqin , Guan Jianjun , Fang Wenmei , Zhang Hongqin , Wang Anzhen 

TITLE=Increased 10-year cardiovascular disease risk in depressed patients with coexisting subclinical hypothyroidism

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2023.1185782

DOI=10.3389/fpsyt.2023.1185782

ISSN=1664-0640

ABSTRACT=Depressive disorder (DD) and subclinical hypothyroidism (SHypo) were both confirmed to be related to cardiovascular disease (CVD) risk. The current study aimed to evaluate the 10-year CVD risk in depressed patients with and without comorbid SHypo and identify potential risk factors associated with CVD risk. We recruited 2395 inpatients with a diagnosis of DD. Venous blood samples were taken from all patients for lipid and thyroid hormones. Framingham Risk Score (FRS) was used to estimate the 10-year CVD risk. In the male group, patients with SHypo had higher BMI, LDL-C, TC and lower HDL-C levels than patients without SHypo. In the female group, patients with SHypo had higher BMI, LDL-C, TG, TC, UA and lower HDL-C, and FT4 than patients without SHypo. All patients with SHypo exhibited a higher 10-year CVD risk than patients without SHypo. Serum TSH levels, BMI, and HAMA scores were critical predictive variables for 10-year CVD risk in female depressed patients with comorbid SHypo. Our study suggests an increased 10-year CVD risk in depressed patients with comorbid SHypo. Serum TSH levels, BMI, and HAMA scores may help predict cardiovascular risk in female patients with SHypo.