AUTHOR=Zheng Yongqiang , Zhang Jinshan , Wang Zefeng , Liu Xiaofeng , Xu Yongquan , Fang Yangzhen , Lin Zhenyu , Lin Liang 

TITLE=Anti-depressant medication use is a risk factor for incident knee surgery and opioid use in patients with knee osteoarthritis

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2023.1243124

DOI=10.3389/fpsyt.2023.1243124

ISSN=1664-0640

ABSTRACT=Objective To investigate whether depression and exposure of antidepressant medication are independent risk factors for incident knee surgery and opioid use in knee osteoarthritis (KOA) patients.We identified all patients who visited our outpatient department with clinically diagnosed with KOA between January 2010 and January 2018. We retrieved their demographic, clinical and radiographic data from the database of our hospital. Next, we analyzed the effect of depression and anti-depressant medication on the incident knee surgery and opioid use in KOA patients.Results A total of 4341 KOA patients were found eligible to form the study population. Incident knee surgery and opioid use in purpose of treating osteoarthritis was observed in 242 and 568 patients, respectively.Incident knee surgery was significantly associated age (OR [95%CI],1.