AUTHOR=Regzedmaa Enkhtuvshin , Ganbat Mandukhai , Sambuunyam Munkhzul , Tsogoo Solongo , Radnaa Otgonbayar , Lkhagvasuren Nasantsengel , Zuunnast Khishigsuren TITLE=A systematic review and meta-analysis of neuroticism and anxiety during the COVID-19 pandemic JOURNAL=Frontiers in Psychiatry VOLUME=Volume 14 - 2023 YEAR=2024 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2023.1281268 DOI=10.3389/fpsyt.2023.1281268 ISSN=1664-0640 ABSTRACT=An extensive investigation and meta-analysis were undertaken to learn more about the connection between neuroticism and anxiety during the COVID-19 outbreak. Due to the pandemic's significant effects on the entire world, concerns have been raised about mental health, specifically individual anxiety levels.Neuroticism, a personality trait associated with emotional instability, may have a significant influence on how people respond under these circumstances. 26 papers that looked at the relationship between neuroticism and anxiety in the context of the COVID-19 outbreak were discovered after doing a thorough literature search utilizing the Cochrane Library, HINARI, Google Scholar, and PUBMED. The study has been submitted to PROSPERO under the number CRD42023452418. There has been usage of thorough Comprehensive Meta-Analysis V4 software. Meta-analysis discovered a highly positive relationship between anxiety and neuroticism, which was validated by 26 studies (OR =3.213, 95% CI 2.352 to 4.391).Our findings demonstrate the importance of considering personality traits, notably neuroticism, when assessing psychological responses to a significant global catastrophe like the COVID-19 epidemic. Potential therapies for reducing the consequences of anxiety should be further researched, especially for those with high levels of neuroticism.