AUTHOR=Ferentinos Panagiotis , Douki Stamatina , Kourkouni Eleni , Dragoumi Dimitra , Smyrnis Nikolaos , Douzenis Athanassios TITLE=Differential predictors of expressed emotion toward individuals with schizophrenia between families and halfway houses JOURNAL=Frontiers in Psychiatry VOLUME=Volume 15 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1322809 DOI=10.3389/fpsyt.2024.1322809 ISSN=1664-0640 ABSTRACT=Background. This study investigated patient- and caregiver-related predictors of expressed emotion (EE) towards individuals with schizophrenia in families and halfway houses and yet understudied differential effects across settings. Methods. We included 40 individuals with schizophrenia living with their families (‘outpatients’) and 40 ‘inpatients’ in halfway houses and recorded the EE of 56 parents or 22 psychiatric nurses, respectively, through Five Minutes Speech Samples. Each outpatient was rated by 1-2 parents; each inpatient by 2-5 nurses. As EE ratings had a multilevel structure, EE predictors were investigated in backward stepwise generalized linear mixed models using ‘buildmer’ R package. We first fitted models including either caregiver- or patient-related predictors in each setting and finally included both types of predictors. Setting-specific patient-related effects were investigated in interaction analyses. Adjustment for multiple tests identified the most robust associations. Results. In multivariate models including either caregiver- or patient-related predictors, nurses’ higher age, shorter work experience and lower inpatients’ negative symptoms robustly predicted higher emotional overinvolvement (EOI). In the final models including both types of predictors, nurses robustly displayed lower EOI (i.e., reduced concern and disengagement) towards inpatients with higher negative symptoms. Several other features were nominally associated with criticism and EOI in each setting. However, no feature robustly predicted criticism in inpatients and criticism/ EOI in outpatients after adjustment for multiple tests. In interaction analyses, higher negative symptoms differentially predicted lower EOI in nurses only. Conclusion. Our findings suggest setting-specific pathogenetic pathways of EOI and might help customize psychoeducational interventions to staff in halfway houses.