AUTHOR=Durkalec-Michalski Krzysztof , Główka Natalia , Podgórski Tomasz , Odrobny Weronika , Krawczyński Marcin , Botwina Ryszard , Bodzicz Stanisław , Nowaczyk Paulina M. 

TITLE=Bovine colostrum supplementation as a new perspective in depression and substance use disorder treatment: a randomized placebo-controlled study

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1366942

DOI=10.3389/fpsyt.2024.1366942

ISSN=1664-0640

ABSTRACT=This randomized, placebo-controlled, double-blind, parallel study aimed to evaluate the effect of 3month supplementation of bovine colostrum (BOV-COL; 8x400 mg per day) on the outcomes of depression treatment in hospitalized patients with substance use disorder (SUD). The hypothesis is that BOV-COL supplementation as an add-on treatment results in favorable alternations in selected blood inflammatory markers or neurotransmitters, leading to better depression treatment outcomes compared with placebo (PLA). Patients with a Minnesota Multiphasic Personality Inventory-2 score ≥60 points were enrolled. Twenty-nine participants (n=18 in the BOV-COL group and n=11 in the PLA group) completed the protocol.