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<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Psychiatry</journal-id>
<journal-title>Frontiers in Psychiatry</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Psychiatry</abbrev-journal-title>
<issn pub-type="epub">1664-0640</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpsyt.2024.1368285</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Psychiatry</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Investigating war trauma, its effects, and associated risk factors on anxiety among high school students in Woldia town, northeast Ethiopia, 2022</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Kassa</surname>
<given-names>Mulat Awoke</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn001">
<sup>*</sup>
</xref>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Anbesaw</surname>
<given-names>Tamrat</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
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<contrib contrib-type="author">
<name>
<surname>Nakie</surname>
<given-names>Girum</given-names>
</name>
<xref ref-type="aff" rid="aff3">
<sup>3</sup>
</xref>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Melkam</surname>
<given-names>Mamaru</given-names>
</name>
<xref ref-type="aff" rid="aff3">
<sup>3</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/1749775"/>
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<contrib contrib-type="author">
<name>
<surname>Azmeraw</surname>
<given-names>Molla</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
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<contrib contrib-type="author">
<name>
<surname>Semagn</surname>
<given-names>Elsabet Gezmu</given-names>
</name>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
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<contrib contrib-type="author">
<name>
<surname>Abate</surname>
<given-names>Biruk Beletew</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
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<aff id="aff1">
<sup>1</sup>
<institution>Department of Nursing, College of Health Sciences, Woldia University</institution>, <addr-line>Woldia</addr-line>, <country>Ethiopia</country>
</aff>
<aff id="aff2">
<sup>2</sup>
<institution>Department of Psychiatry, College of Medicine and Health Sciences, Wollo University</institution>, <addr-line>Dessie</addr-line>, <country>Ethiopia</country>
</aff>
<aff id="aff3">
<sup>3</sup>
<institution>Department of Psychiatry, College of Medicine and Health Sciences, University of Gondar</institution>, <addr-line>Gondar</addr-line>, <country>Ethiopia</country>
</aff>
<aff id="aff4">
<sup>4</sup>
<institution>Department of Veterinary Parasitology, College of Veterinary Medicine, Wollo University</institution>, <addr-line>Dessie</addr-line>, <country>Ethiopia</country>
</aff>
<author-notes>
<fn fn-type="edited-by">
<p>Edited by: Shinsuke Hidese, Teikyo University, Japan</p>
</fn>
<fn fn-type="edited-by">
<p>Reviewed by: Omneya Ibrahim, Suez Canal University, Egypt</p>
<p>Rahim Badrfam, Alborz University of Medical Sciences, Iran</p>
<p>Joseph Lobo, Bulacan State University, Philippines</p>
</fn>
<fn fn-type="corresp" id="fn001">
<p>*Correspondence: Mulat Awoke Kassa, <email xlink:href="mailto:mulatawoke45@gmail.com">mulatawoke45@gmail.com</email>
</p>
</fn>
</author-notes>
<pub-date pub-type="epub">
<day>10</day>
<month>07</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="collection">
<year>2024</year>
</pub-date>
<volume>15</volume>
<elocation-id>1368285</elocation-id>
<history>
<date date-type="received">
<day>10</day>
<month>01</month>
<year>2024</year>
</date>
<date date-type="accepted">
<day>13</day>
<month>06</month>
<year>2024</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#xa9; 2024 Kassa, Anbesaw, Nakie, Melkam, Azmeraw, Semagn and Abate</copyright-statement>
<copyright-year>2024</copyright-year>
<copyright-holder>Kassa, Anbesaw, Nakie, Melkam, Azmeraw, Semagn and Abate</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<abstract>
<sec>
<title>Background</title>
<p>Anxiety symptoms are the most frequent mental health problems in the world, and it is a serious public health concern, especially among adolescents, because if left untreated, adolescent anxiety can have a number of detrimental effects, including lower academic performance, strained relationships with friends and family, substance addiction, thoughts of suicide and homicide, and trouble finding work. While this vulnerability is concerning in all situations, it is particularly critical in armed conflict areas. Ethiopia is one of the most recent war-affected countries, but to the best of our knowledge, limited studies focused on adolescents in this context. Therefore, this study assessed the experience of war trauma and its effects on anxiety symptoms among high school students in Woldia town, Ethiopia.</p>
</sec>
<sec>
<title>Objective</title>
<p>We assessed the experience of war trauma and its effects on anxiety among high school students, as well as associated risk factors, in war-affected areas in Woldia town, northeast Ethiopia.</p>
</sec>
<sec>
<title>Methods</title>
<p>A cross-sectional study design was conducted from May 23 to June 08 2022. Data were collected from high school students in Woldia town. Bivariable and multivariable logistic regression analyses were used to identify independent factors associated with anxiety.</p>
</sec>
<sec>
<title>Results</title>
<p>A total of 624 out of 660 students participated in the study (94.5% response rate). The prevalence of anxiety among high school students in Woldia town was 39.7%. In the multivariable analysis, having depression (AOR = 9.24, 95% CI: 6.27, 13.64), witnessing the murder of family/friends (AOR = 1.93, 95% CI: 1.05, 3.57), being of female sex (AOR=1.59, 95% CI: 1.08, 2.36), and having a family history of mental illness (AOR=1.69, 95% CI: 1.00, 2.85) were factors significantly associated with anxiety.</p>
</sec>
<sec>
<title>Conclusions and recommendations</title>
<p>The prevalence of anxiety in this study was approximately two in five high school students. Therefore, we recommend that the Ministry of Education collaborate with the Ministry of Health to expand and implement mental health services in high schools to promote the wellbeing of students for the prevention of anxiety.</p>
</sec>
</abstract>
<kwd-group>
<kwd>anxiety</kwd>
<kwd>high school students</kwd>
<kwd>adolescents</kwd>
<kwd>war</kwd>
<kwd>conflict</kwd>
<kwd>Ethiopia</kwd>
</kwd-group>
<counts>
<fig-count count="3"/>
<table-count count="2"/>
<equation-count count="1"/>
<ref-count count="89"/>
<page-count count="10"/>
<word-count count="5019"/>
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<custom-meta-wrap>
<custom-meta>
<meta-name>section-in-acceptance</meta-name>
<meta-value>Adolescent and Young Adult Psychiatry</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec id="s1" sec-type="intro">
<title>Introduction</title>
<p>Adolescence is a critical stage of life marked by significant and quick changes in one&#x2019;s physical, intellectual, emotional, and psychological makeup (<xref ref-type="bibr" rid="B1">1</xref>), as well as the emergence of potentially dangerous or beneficial lifelong habits. Half of all mental health illnesses that completely develop in adulthood, according to the WHO, start before the age of 14 (<xref ref-type="bibr" rid="B2">2</xref>).</p>
<p>Anxiety is a normal human emotion characterized by various responses (e.g., behavioral, affective, and cognitive) to perceived threats (<xref ref-type="bibr" rid="B3">3</xref>). However, when such reactions result in a great deal of distress or are out of proportion to the perceived source of stress, anxiety may be deemed excessive or pathological (<xref ref-type="bibr" rid="B4">4</xref>). Anxiety is defined by its physical symptoms such as palpations, trembling, and shortness of breath, in addition to subjective feelings, thoughts, and observable fight-flight-freeze behavior (<xref ref-type="bibr" rid="B5">5</xref>). The Diagnostic and Statistical Manual of Mental Disorders (DSM-5) lists restlessness or feeling tense or agitated, easily becoming fatigued, trouble focusing or losing one&#x2019;s train of thought, irritability, muscle tension, and sleep disturbances (difficulty falling or staying asleep, or restless, unsatisfactory sleep) as symptoms of anxiety (<xref ref-type="bibr" rid="B6">6</xref>, <xref ref-type="bibr" rid="B7">7</xref>).</p>
<p>In the late 20th century, there was an increase in armed conflicts, wars, and insurgencies that had a direct impact on civilian populations. During this period, acts of violence and attacks against civilians became common occurrences in global conflicts, resulting in perilous conditions, insecurity, and distress among affected populations. More than a billion young people worldwide reside in countries where armed conflicts, wars, or terrorism are prevalent (<xref ref-type="bibr" rid="B8">8</xref>). It is well recognized that the prevalence and severity of mental illnesses in people are significantly impacted by war. In particular, anxiety, depression, and PTSD are the most prevalent mental health problems reported among populations affected by war (<xref ref-type="bibr" rid="B9">9</xref>). Anxiety is one of the most prevalent mental health problems for children and adolescents (<xref ref-type="bibr" rid="B10">10</xref>), and living in war-affected areas makes the problem more prevalent and complex (<xref ref-type="bibr" rid="B11">11</xref>, <xref ref-type="bibr" rid="B12">12</xref>).</p>
<p>Since June 2021, the Tigray People&#x2019;s Liberation Front (TPLF) forces in Ethiopia have been engaged in an open assault against the Federal Republic Government of Ethiopia in the Amhara and Afar regions. As a consequence, the local population has been subjected to severe economic and social hardships. The invading forces specifically targeted various individuals, including rural farmers, urban residents, teachers, and medical professionals who were not politically involved. Among those affected, children and adolescents face the greatest risk of suffering the detrimental effects of these hostilities, as they must navigate the challenges of normal developmental growth while being exposed to an environment of insecurity and violence, which heightens their vulnerability and susceptibility (<xref ref-type="bibr" rid="B13">13</xref>). In addition, the conflict has resulted in 1,035 unwanted pregnancies, multiple cases of rape, and various forms of physical and sexual abuse of women (<xref ref-type="bibr" rid="B14">14</xref>). Changes in social dynamics, unemployment, intergroup aggression, poverty, and unstable living conditions are all results of armed conflicts. Therefore, there is a clear relationship between the post-war period and a lower quality of life, which leads to a range of mental health problems, including anxiety (<xref ref-type="bibr" rid="B15">15</xref>).</p>
<p>The prevalence of anxiety among adolescents varies widely across different regions, with reported rates ranging from 23.7% to 94.9% (<xref ref-type="bibr" rid="B16">16</xref>&#x2013;<xref ref-type="bibr" rid="B19">19</xref>). In 2021, a meta-analysis found a pooled prevalence of 21% (<xref ref-type="bibr" rid="B20">20</xref>), while another meta-analysis during the COVID-19 pandemic revealed a pooled prevalence of 26% (<xref ref-type="bibr" rid="B21">21</xref>). Additionally, among child and adolescent refugees and asylum seekers, a meta-analysis showed a prevalence of 15.7% (<xref ref-type="bibr" rid="B22">22</xref>). Specific studies conducted in various countries and contexts found the following prevalence rates: 18.4% in the USA (<xref ref-type="bibr" rid="B23">23</xref>), 34% in Central Europe during the Russian-Ukrainian war in 2022 (<xref ref-type="bibr" rid="B24">24</xref>), 37.3% among adolescents in Southwest China following a severe earthquake (<xref ref-type="bibr" rid="B25">25</xref>), 37.4% in China during the COVID-19 pandemic (<xref ref-type="bibr" rid="B26">26</xref>), 67.1% and 59.1% among students in Malaysia (<xref ref-type="bibr" rid="B27">27</xref>, <xref ref-type="bibr" rid="B28">28</xref>), 22.2% and 37% among adolescents in Palestine (<xref ref-type="bibr" rid="B29">29</xref>, <xref ref-type="bibr" rid="B30">30</xref>), 24.4% among students in India (<xref ref-type="bibr" rid="B31">31</xref>), and 66.2% and 54% in Saudi Arabia (<xref ref-type="bibr" rid="B32">32</xref>, <xref ref-type="bibr" rid="B33">33</xref>). Additionally, prevalence rates were reported as 14.9% and 64% among students in Kuwait and Beirut (<xref ref-type="bibr" rid="B34">34</xref>, <xref ref-type="bibr" rid="B35">35</xref>), 40.6% and 53.2% among students in Iraq and Pakistan (<xref ref-type="bibr" rid="B36">36</xref>, <xref ref-type="bibr" rid="B37">37</xref>), and 41.2% among high school students in Jordan (<xref ref-type="bibr" rid="B38">38</xref>). Further studies in Egypt and Ethiopia reported prevalence rates of 21% and 66.7%, respectively, among students (<xref ref-type="bibr" rid="B39">39</xref>, <xref ref-type="bibr" rid="B40">40</xref>).</p>
<p>Different variables can affect the prevalence of anxiety among adolescents, as studies have reported. Studies have consistently shown that being of female sex is associated with a higher risk of experiencing anxiety compared to the male sex. While the exact reasons for this gender difference are not fully understood, it is suggested that a combination of biological, hormonal, and sociocultural factors may contribute to this increased vulnerability. Biological factors such as hormonal fluctuations during the menstrual cycle and pregnancy, as well as societal expectations and gender roles, can influence the prevalence of anxiety in women (<xref ref-type="bibr" rid="B29">29</xref>, <xref ref-type="bibr" rid="B33">33</xref>, <xref ref-type="bibr" rid="B41">41</xref>, <xref ref-type="bibr" rid="B42">42</xref>). Depression is widely recognized as a significant risk factor for anxiety. The relationship between depression and anxiety is highly intertwined, with individuals often experiencing both conditions simultaneously. Depression involves persistent feelings of sadness, hopelessness, and a loss of interest in activities, while anxiety is characterized by excessive worry, fear, and a sense of restlessness. The coexistence of depression and anxiety can exacerbate the severity of both conditions and create a more challenging clinical picture (<xref ref-type="bibr" rid="B41">41</xref>). Having a family history of mental illness has consistently been identified as a risk factor for developing anxiety. Genetic predisposition plays a role in this association, as certain inherited traits or vulnerabilities can increase the likelihood of developing anxiety disorders. Additionally, shared environmental factors within families, such as parenting styles or exposure to stressful events, can contribute to the transmission of anxiety-related behaviors and coping mechanisms from one generation to the next (<xref ref-type="bibr" rid="B43">43</xref>&#x2013;<xref ref-type="bibr" rid="B48">48</xref>). Exposure to war situations, such as witnessing the murder of family or friends is another risk factor for developing anxiety, as studies have revealed. The profound trauma and psychological impact of such experiences can lead to the development of anxiety disorders. Exposure to violence, loss, and the constant threat to personal safety can significantly affect the mental well-being of an individual, contributing to the manifestation of anxiety (<xref ref-type="bibr" rid="B41">41</xref>, <xref ref-type="bibr" rid="B49">49</xref>, <xref ref-type="bibr" rid="B50">50</xref>). Poor social support has been established as a significant risk factor for anxiety. Social support refers to the availability of emotional, instrumental, and informational assistance from others, including family, friends, and community networks. When individuals lack strong support systems, nurturing relationships, or a sense of belonging, they experience an increased risk of developing anxiety. Social support plays a crucial role in buffering the negative effects of stress and providing a sense of security (<xref ref-type="bibr" rid="B48">48</xref>, <xref ref-type="bibr" rid="B51">51</xref>). Individuals who have been subjected to torture or physical abuse are at an elevated risk of developing anxiety. The experience of severe trauma and the resulting psychological wounds can significantly impact mental health, leading to the development of anxiety disorders. Survivors of torture or abuse often require specialized support to address the associated anxiety (<xref ref-type="bibr" rid="B52">52</xref>). A history of substance use, such as smoking cigarettes, is linked to an increased likelihood of experiencing anxiety. Substance use can be both a contributing factor and a consequence of anxiety disorders. Some individuals may turn to substances as a form of self-medication to alleviate anxiety temporarily, but in the long run, substance use can exacerbate anxiety and lead to the development of anxiety disorders (<xref ref-type="bibr" rid="B53">53</xref>). A high level of perceived stress has been identified as a significant risk factor for anxiety. Perceived stress refers to subjective appraisal of the stressfulness of life events and circumstances of an individual. When individuals consistently perceive their environment as overwhelming and experience a sense of being unable to cope effectively, they are more likely to develop anxiety. Prolonged exposure to chronic stressors can dysregulate the body&#x2019;s stress response systems, leading to the manifestation of anxiety (<xref ref-type="bibr" rid="B54">54</xref>). Studies have shown that older students are more susceptible to experiencing anxiety compared to younger individuals. The transition to adulthood, such as entering higher education or facing new responsibilities in professional or personal domains, can contribute to heightened anxiety levels. The increased pressure to meet academic or career expectations, coupled with the challenges of managing multiple roles and responsibilities, can contribute to anxiety among older students (<xref ref-type="bibr" rid="B54">54</xref>). Having a chronic medical illness is also a risk factor, which increases the risk of developing anxiety. Chronic illnesses, such as diabetes, cardiovascular disease, or autoimmune disorders, can have a significant impact on an individual&#x2019;s physical and psychological well-being. The uncertainty, limitations, and emotional burden associated with managing a chronic condition can contribute to heightened anxiety levels. The presence of anxiety can further complicate the management and prognosis of the underlying medical condition (<xref ref-type="bibr" rid="B43">43</xref>).</p>
<p>Adolescent anxiety, if left untreated, can have numerous negative consequences, such as lower academic performance, negative relationships with friends and family, substance abuse, suicidal and homicidal thoughts, and difficulties in finding employment (<xref ref-type="bibr" rid="B55">55</xref>, <xref ref-type="bibr" rid="B56">56</xref>). Additionally, untreated anxiety during adolescence increases the likelihood of developing psychiatric problems in adulthood, such as anxiety disorders, major depression, suicide attempts, and psychiatric hospitalizations (<xref ref-type="bibr" rid="B57">57</xref>). Anxiety disorders are associated with significant disability and a reduced quality of life due to their high prevalence, chronic nature, and tendency to co-occur with other mental health disorders (<xref ref-type="bibr" rid="B58">58</xref>). Moreover, anxiety disorders impose a substantial economic burden, with an estimated cost of &#x20ac;74.4 billion in 2010 across 30 European Union countries (<xref ref-type="bibr" rid="B59">59</xref>).</p>
<p>Despite Ethiopia&#x2019;s recent experience of war and trauma, particularly during the conflict between the Government of Ethiopia and the Tigray People&#x2019;s Liberation Front (TPLF), there is limited knowledge about the impact of such events on anxiety among high school students in Ethiopia. Therefore, this study aimed to provide baseline data and contribute to the planning, prevention, and treatment of anxiety in adolescents. The research questions addressed in this study are the following: 1. What is the prevalence of anxiety among high school adolescents who have experienced war? 2. Which factors influence the magnitude of anxiety among high school adolescents who have experienced war?</p>
</sec>
<sec id="s2" sec-type="materials|methods">
<title>Materials  and methods</title>
<sec id="s2_1">
<title>Study area, period, and populations</title>
<p>A school-based cross-sectional study design was conducted from May 23 to June 08 2022, among four secondary and preparatory schools in Woldia town. The schools are Woldia Secondary and Preparatory School, Genetie Secondary and Preparatory School, Mesenado Secondary and Preparatory School, and Millennium Secondary and Preparatory School. Woldia town is located 521 km from Addis Ababa, the Ethiopian capital city, in the Amhara National Regional State of North Wollo zone. There are 46,139 residents in Woldia town; of these, 23,000 are men and 23,139 are women. Approximately 80.49% of the entire population are Ethiopian orthodox Christians followers, while 18.46% are Muslim religion followers. The study included all high school students who attended their class during data collection time and lived in the study area for a minimum of 1 year. Students who were unable to communicate because of acute sickness during the time of data collection and students who lived in the study area for less than 1 year were both excluded from the study.</p>
</sec>
<sec id="s2_2">
<title>Sample size calculations for the study</title>
<p>The sample size of this study was calculated by assuming a single population proportion formula. We calculate sample size using the proportion (P) from the previous study with a proportion of 48.9% (<xref ref-type="bibr" rid="B60">60</xref>) with a 95% confidence interval (CI), a margin of error of 4%, and a 10% non-response rate.</p>
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</mml:math>
</disp-formula>
<p>where n = required sample size, p = prevalence, Z&#x3b1;/2 = 1.96 with 95% CI, and d = margin of error = 0.04. The prevalence of anxiety that was taken from a previous study was 48.9% (<xref ref-type="bibr" rid="B60">60</xref>). Therefore, the required sample size for this study is 660. Prior to data collection, students were stratified by grade level (grades 9, 10, 11, and 12) considering each grade level as a stratum. The total number of students from the four schools was 5,100, as data obtained from zonal education bureau indicated. Among these, grade 9 students were 1,606, grade 10 were 1,230, grade 11 were 1,179, and grade 12 were 1,085. Then, we made a proportional allocation for each stratum (grade levels), and we drew 208 students from grade 9, 159 students from grade 10, 153 students from grade 11, and 140 students from grade 12. Then we used the computer-generated lottery method by taking the identification number of the student to select study units from each stratum. Finally, the selected students were taken to a hall, and then the questionnaires were administered after orientation.</p>
<p>The questionnaires in this study include both dependent and independent variables. Our dependent variable was anxiety, which was assessed using the nine-item GAD-7 tool. The independent variables include socio-demographic characteristics of study participants, such as age, sex, and grade level, which were collected using structured socio-demographic questions. Clinical factors such as family history of mental illness, having depression, history of chronic medical illness, and trauma-related factors were assessed using a structured yes/no question, and substance-related factors, including khat, tobacco, and alcohol, were assessed using an alcohol, smoking, and substance involvement screening test (ASSIST) tool (<xref ref-type="bibr" rid="B61">61</xref>, <xref ref-type="bibr" rid="B62">62</xref>). Psychosocial factors, including social support level, were assessed using the OSLO 3-item social support scale with scores between 3 and 8 classified as poor social support level, a score between 9 and 11 as medium social support level, and a score between 12 and 14 as strong social support level. The perceived stress (PSS) scale, which has 10 items with each item having 0&#x2013;4 scores and total scores ranging from 0&#x2013;40, was used to quantify the level of perceived stress. Respondents with scores between 0 and 13 were considered to have low-level perceived stress, those between 14 and 26 with moderate-level perceived stress, and those between 27 and 40 with high-level perceived stress (<xref ref-type="bibr" rid="B63">63</xref>).</p>
<p>The data quality of this study was controlled by the appropriate translation of the questionnaire into the local Amharic language. In addition, the data collectors and supervisors received training before the actual data collection period, and each completed questionnaire is checked. The necessary feedback is also offered to the data collectors each morning. Furthermore, the questionnaire was pretested one week before the actual data collection time for 5% (n=33) of students at Meket Secondary and Preparatory School, which is the main study area. The dependent variable assessment tool GAD-7 had a Cronbach alpha of 0.78. Based on the feedback obtained from the pretest, an appropriate modification was made to the questionnaire. The collected data were coded, edited, entered, and checked into the computer using EPI data version 4.6.02 and imported to STATA version 14.0 to generate descriptive statistics like means, standard deviation, frequency, and percentages. To determine an association between dependent and independent variables, adjusted odds ratios were used using logistic regression, and the significance level was determined using a confidence interval of 95%. Bivariable and multivariable logistic regression analyses were used to identify the independent predictors of anxiety. Each independent variable was separately entered into the bivariable analysis. Then, variables with a p-value&lt;0.2 in bivariable analysis were entered into multivariable analysis. Then, variables that showed a statistically significant association with a p-value&lt;0.05 on logistic regression were considered to be the predictors of anxiety.</p>
</sec>
<sec id="s2_3">
<title>Ethical considerations</title>
<p>The ethical clearance for this study was obtained from the institutional review board (IRB) of the University of Gondar. Information about the study was explained to each study participant in the information sheet. Written informed consent from the study participants who were &gt;18 years old and assent for those students&lt;18 years old from their parents, caregivers, or guardians was obtained. The participants were given the right to refuse or discontinue participation at any time, and the chance to ask anything about the study was given. The privacy and confidentiality of study participants&#x2019; information were kept anonymously at every stage of data collection by excluding any personal identifiers in the questionnaire. Students were not forced to participate or receive any monetary incentive, and it was solely voluntary-based.</p>
</sec>
</sec>
<sec id="s3" sec-type="results">
<title>Results</title>
<sec id="s3_1">
<title>Sociodemographic characteristics of the study participants</title>
<p>Data were obtained from 624 high school students with a response rate of 96%. The mean age of the participants was 17.89 &#xb1; 1.66. The majority of the study participants (42.5%) were older than 18 years. More than half (53.4%) of the participants were men, and the rest were women. 64.7% of students were from rural areas, and the rest were from urban areas, as shown in <xref ref-type="table" rid="T1">
<bold>Table&#xa0;1</bold>
</xref>.</p>
<table-wrap id="T1" position="float">
<label>Table&#xa0;1</label>
<caption>
<p>Sociodemographic characteristics of the study participants.</p>
</caption>
<table frame="hsides">
<thead>
<tr>
<th valign="top" align="left">Variables</th>
<th valign="top" align="left">Categories</th>
<th valign="top" align="left">Frequency</th>
<th valign="top" align="left">Percent</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" rowspan="3" align="left">&#x2003;Age</td>
<td valign="top" align="left">
<inline-formula>
<mml:math display="inline" id="im1">
<mml:mo>&lt;</mml:mo>
</mml:math>
</inline-formula> 18</td>
<td valign="top" align="left">246</td>
<td valign="top" align="left">39.4</td>
</tr>
<tr>
<td valign="top" align="left">=18</td>
<td valign="top" align="left">113</td>
<td valign="top" align="left">18.1</td>
</tr>
<tr>
<td valign="top" align="left">
<inline-formula>
<mml:math display="inline" id="im2">
<mml:mo>&gt;</mml:mo>
</mml:math>
</inline-formula> 18</td>
<td valign="top" align="left">265</td>
<td valign="top" align="left">42.5</td>
</tr>
<tr>
<td valign="top" rowspan="2" align="left">&#x2003;Sex</td>
<td valign="top" align="left">Male</td>
<td valign="top" align="left">333</td>
<td valign="top" align="left">53.4</td>
</tr>
<tr>
<td valign="top" align="left">Female</td>
<td valign="top" align="left">291</td>
<td valign="top" align="left">46.6</td>
</tr>
<tr>
<td valign="top" rowspan="2" align="left">Residency</td>
<td valign="top" align="left">Rural</td>
<td valign="top" align="left">404</td>
<td valign="top" align="left">64.7</td>
</tr>
<tr>
<td valign="top" align="left">Urban</td>
<td valign="top" align="left">220</td>
<td valign="top" align="left">35.3</td>
</tr>
<tr>
<td valign="top" rowspan="4" align="left">Grade level</td>
<td valign="top" align="left">9</td>
<td valign="top" align="left">204</td>
<td valign="top" align="left">32.7</td>
</tr>
<tr>
<td valign="top" align="left">10</td>
<td valign="top" align="left">176</td>
<td valign="top" align="left">28.2</td>
</tr>
<tr>
<td valign="top" align="left">11</td>
<td valign="top" align="left">124</td>
<td valign="top" align="left">19.9</td>
</tr>
<tr>
<td valign="top" align="left">12</td>
<td valign="top" align="left">120</td>
<td valign="top" align="left">19.2</td>
</tr>
<tr>
<td valign="top" rowspan="3" align="left">Semester average score in percentage</td>
<td valign="top" align="left">
<inline-formula>
<mml:math display="inline" id="im3">
<mml:mrow>
<mml:mo>&lt;</mml:mo>
<mml:mn>70</mml:mn>
<mml:mo>%</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula>
</td>
<td valign="top" align="left">355&#x2003;</td>
<td valign="top" align="left">56.9</td>
</tr>
<tr>
<td valign="top" align="left">70%&#x2013;84.5%</td>
<td valign="top" align="left">224</td>
<td valign="top" align="left">35.9</td>
</tr>
<tr>
<td valign="top" align="left">
<inline-formula>
<mml:math display="inline" id="im4">
<mml:mrow>
<mml:mo>&#x2265;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 85%</td>
<td valign="top" align="left">45</td>
<td valign="top" align="left">7.2</td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
<sec id="s3_2">
<title>Clinical characteristics of the study respondents</title>
<p>Out of the total participants, 11% had a history of chronic medical illness, 17.3% had a family history of mental illness, and 40.9% had depression, as seen in <xref ref-type="fig" rid="f1">
<bold>Figure&#xa0;1</bold>
</xref>.</p>
<fig id="f1" position="float">
<label>Figure&#xa0;1</label>
<caption>
<p>Clinical characteristics of study participants.</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyt-15-1368285-g001.tif"/>
</fig>
</sec>
<sec id="s3_3">
<title>Substance-use characteristics of the study participants</title>
<p>Regarding substance use of the participants, 71.3% were drinking alcohol at least once in their lives, whereas students who used khat or cigarettes at least once in their lives were 15.7% and 12.5%, respectively; and 32.7% of them drank alcohol in the last 3 months, as seen in <xref ref-type="fig" rid="f2">
<bold>Figure&#xa0;2</bold>
</xref>.</p>
<fig id="f2" position="float">
<label>Figure&#xa0;2</label>
<caption>
<p>Substance related characteristics of study participants.</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyt-15-1368285-g002.tif"/>
</fig>
</sec>
<sec id="s3_4">
<title>Trauma type and psychosocial-related characteristics of the study participants</title>
<p>Among the study participants, 60.3% of them were in a warfighting situation, 9.5% were tortured/beaten, 12.3% had been imprisoned against their will, 10.7% had exposure to traumatic events through witnessing the murder of family or friends, 8.3% had ill health without medical care as seen in <xref ref-type="fig" rid="f3">
<bold>Figure&#xa0;3</bold>
</xref>. A total of 30.3% of the students had strong social support, 42.2% had moderate social support, and 27.6% had poor social support. Lastly, 38.8%, 32.5%, and 28.7% of the students had high, moderate, and low levels of perceived stress, respectively.</p>
<fig id="f3" position="float">
<label>Figure&#xa0;3</label>
<caption>
<p>Individual trauma types that the study participants faced.</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyt-15-1368285-g003.tif"/>
</fig>
</sec>
<sec id="s3_5">
<title>The prevalence and associated risk factors of anxiety in this study</title>
<p>In this study, the overall prevalence of anxiety among high school students was 39.7% (95% CI: 35.9%, 43.6%). Having depression, exposure to traumatic events through witnessing the murder of family or friends, having ill health without medical care, witnessing the murder of a stranger, being of female sex, having a family history of mental illness, having chronic medical illness, being older than 18 years, and having poor social support were factors associated with anxiety at p&lt;0.2 in binary logistic regression. Finally, the analysis of the multivariable logistic regression model revealed that having depression, being of female sex, exposure to traumatic events through witnessing the murder of family members or friends, and having a family history of mental illness were found to be significantly associated with anxiety, with a 95% CI and a p-value&lt;0.05, as seen in <xref ref-type="table" rid="T2">
<bold>Table&#xa0;2</bold>
</xref>. Students who had depression were nine times more likely to have anxiety when compared to students who did not have depression (AOR = 9.24, 95% CI: 6.27, 13.64). Students who were exposed to traumatic events such as witnessing the murder of family members or friends were two times more likely to have anxiety than students who did not witness the murder of family members/friends (AOR = 1.93, 95% CI: 1.05, 3.57). Female students had 1.6 times greater anxiety than male students (AOR=1.59, 95% CI: 1.08, 2.36). The students who had a family history of mental illness were 1.7 times more likely to have anxiety than the students who had no family history of mental illness (AOR=1.69, 95% CI: 1.00, 2.85).</p>
<table-wrap id="T2" position="float">
<label>Table&#xa0;2</label>
<caption>
<p>Bivariable and multivariable analyses of factors associated with anxiety among high school students in Woldia town, 2022 (n = 624).</p>
</caption>
<table frame="hsides">
<thead>
<tr>
<th valign="top" align="left"/>
<th valign="top" align="left">Category</th>
<th valign="top" colspan="2" align="left">Anxiety</th>
<th valign="top" align="left">COR (and 95% CI)</th>
<th valign="top" align="left">AOR (and 95% CI)</th>
</tr>
<tr>
<th valign="top" align="left">Variables</th>
<th valign="top" align="left"/>
<th valign="top" align="left">Yes</th>
<th valign="top" align="left">No</th>
<th valign="top" align="left"/>
<th valign="top" align="left"/>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Depression</td>
<td valign="top" align="left">Yes<break/>No</td>
<td valign="top" align="left">178<break/>70</td>
<td valign="top" align="left">77<break/>299</td>
<td valign="top" align="left">9.87 (6.79&#x2013;14.33)</td>
<td valign="top" align="left">9.24 (6.27&#x2013;13.64)***</td>
</tr>
<tr>
<td valign="top" align="left">Social support level</td>
<td valign="top" align="left">Poor<break/>Moderate</td>
<td valign="top" align="left">84<break/>97</td>
<td valign="top" align="left">88<break/>166</td>
<td valign="top" align="left">1.73 (1.13&#x2013;2.65)</td>
<td valign="top" align="left">1.34 (0.80&#x2013;2.23)</td>
</tr>
<tr>
<td valign="top" align="left">Family history of mental illness</td>
<td valign="top" align="left">Yes<break/>No</td>
<td valign="top" align="left">58<break/>190</td>
<td valign="top" align="left">52<break/>324</td>
<td valign="top" align="left">1.90 (1.25&#x2013;2.88)</td>
<td valign="top" align="left">1.69 (1.00&#x2013;2.85)*</td>
</tr>
<tr>
<td valign="top" align="left">Sex</td>
<td valign="top" align="left">Female<break/>Male</td>
<td valign="top" align="left">143<break/>105</td>
<td valign="top" align="left">148<break/>228</td>
<td valign="top" align="left">2.09 (1.51&#x2013;2.90)</td>
<td valign="top" align="left">1.59 (1.08&#x2013;2.36)*</td>
</tr>
<tr>
<td valign="top" align="left">Witnessing murder<break/>of family/friends</td>
<td valign="top" align="left">Yes<break/>No</td>
<td valign="top" align="left">37<break/>211</td>
<td valign="top" align="left">30<break/>346</td>
<td valign="top" align="left">2.02 (1.21&#x2013;3.37)</td>
<td valign="top" align="left">1.93 (1.05&#x2013;3.57)*</td>
</tr>
<tr>
<td valign="top" align="left">Age</td>
<td valign="top" align="left">&gt; 18<break/>18</td>
<td valign="top" align="left">121<break/>42</td>
<td valign="top" align="left">144<break/>71</td>
<td valign="top" align="left">1.59 (1.11&#x2013;2.27)</td>
<td valign="top" align="left">1.40 (0.91&#x2013;2.16)</td>
</tr>
<tr>
<td valign="top" align="left">Ill health without medical care</td>
<td valign="top" align="left">Yes<break/>No</td>
<td valign="top" align="left">14<break/>234</td>
<td valign="top" align="left">38<break/>338</td>
<td valign="top" align="left">0.53 (0.28&#x2013;1.00)</td>
<td valign="top" align="left">0.52 (0.25&#x2013;1.10)</td>
</tr>
<tr>
<td valign="top" align="left">Witnessing<break/>murder of stranger</td>
<td valign="top" align="left">Yes<break/>No</td>
<td valign="top" align="left">40<break/>208</td>
<td valign="top" align="left">80<break/>296</td>
<td valign="top" align="left">0.71 (0.46&#x2013;1.08)</td>
<td valign="top" align="left">0.89 (0.54&#x2013;1.48)</td>
</tr>
<tr>
<td valign="top" align="left">Having chronic medical illness</td>
<td valign="top" align="left">Yes<break/>No</td>
<td valign="top" align="left">33<break/>215</td>
<td valign="top" align="left">36<break/>340</td>
<td valign="top" align="left">1.44 (0.87&#x2013;2.39)</td>
<td valign="top" align="left">1.33 (0.71&#x2013;2.49)</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p>*= p-value&lt; 0.05, ** = p-value&lt; 0.01, and *** =p value&lt; 0.001.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</sec>
</sec>
<sec id="s4" sec-type="discussion">
<title>Discussion</title>
<sec id="s4_1">
<title>Prevalence of anxiety among the study participants</title>
<p>The findings of this study showed that the prevalence of anxiety among high school students was 39.7% (95% CI: 35.9%, 43.6%), which is consistent with similar studies conducted in China (37.3%) (<xref ref-type="bibr" rid="B25">25</xref>), Palestine (37%) (<xref ref-type="bibr" rid="B30">30</xref>), Iraq (40.6%) (<xref ref-type="bibr" rid="B36">36</xref>), and Jordan (41.2%) (<xref ref-type="bibr" rid="B38">38</xref>). However, the prevalence in this study was higher than studies conducted in Uganda, India, and Nepal, which reported prevalence rates of 26.6% (<xref ref-type="bibr" rid="B41">41</xref>), 24.4% (<xref ref-type="bibr" rid="B31">31</xref>), and 10% (<xref ref-type="bibr" rid="B64">64</xref>), respectively. The possible reason for this difference could be the difference in assessment tools these studies used. For example, in a study conducted in Uganda, the MINI International Neuropsychiatric Interview for Children and Adolescents (M.I.N.I.-KID) was used; in India, the depression anxiety stress scale (DASS) was used; in Nepal, the Beck anxiety inventory (BAI) was used; but in this study, the GAD-7 tool was used.</p>
<p>Additionally, the difference in the exposure status to war trauma experiences among the study participants in these studies may have contributed to the difference in the prevalence rates; for example, in studies conducted in Uganda and Nepal, their study participants were non-war experiencing school students, but in this study, the study participants experienced war trauma, and different studies revealed that exposure to war trauma experiences is one of the factors that can increase the risk of having anxiety (<xref ref-type="bibr" rid="B65">65</xref>&#x2013;<xref ref-type="bibr" rid="B67">67</xref>). Moreover, differences in sample sizes across these studies may also explain the variation in prevalence rates. On the other hand, the prevalence of anxiety in this study was lower than studies conducted in Ethiopia, Beirut, Malaysia, Saudi Arabia, and Pakistan, which reported prevalence rates of 66.7% (<xref ref-type="bibr" rid="B43">43</xref>), 64% (<xref ref-type="bibr" rid="B35">35</xref>), 67.1% (<xref ref-type="bibr" rid="B27">27</xref>), 66.2% (<xref ref-type="bibr" rid="B32">32</xref>), and 53.2% (<xref ref-type="bibr" rid="B37">37</xref>), respectively. The reason for this difference could be explained by the difference in the assessment tools these studies used. For example, in Malaysia, a 21-item depression, anxiety, and stress scale tool was used; in Pakistan, the Aga Khan University Anxiety and Depression Scale (AKU-ADS) tool was used; in Beirut, a parent-short validated version of the Screen for Childhood Anxiety Related Disorder (SCARED) tool was used; but in this study, the GAD-7 tool was used. Furthermore, the difference in the proportion of female participants in these studies may have influenced the prevalence rates, as being of female sex has been associated with a higher risk of anxiety (<xref ref-type="bibr" rid="B33">33</xref>, <xref ref-type="bibr" rid="B38">38</xref>, <xref ref-type="bibr" rid="B47">47</xref>). For example, in a study done in Pakistan, the majority of study participants were female (72%), whereas the number of female participants in this study was 46.6%. Additionally, sample size differences could also contribute to the variations in prevalence rates.</p>
</sec>
<sec id="s4_2">
<title>Associated risk factors for anxiety among the study participants</title>
<p>The result of this study showed that high school students with depression were nine times more likely to have anxiety compared to those without depression. This finding is supported by previous studies (<xref ref-type="bibr" rid="B64">64</xref>, <xref ref-type="bibr" rid="B68">68</xref>, <xref ref-type="bibr" rid="B69">69</xref>), suggesting that the neurological abnormalities associated with depression can also lead to the development of anxiety (<xref ref-type="bibr" rid="B70">70</xref>, <xref ref-type="bibr" rid="B71">71</xref>). Another factor could be the added difficulty and increased challenge of managing anxious feelings when experiencing symptoms of depression, such as hopelessness and sadness. This can potentially escalate into full-blown anxiety symptoms over time (<xref ref-type="bibr" rid="B72">72</xref>), and treating these depressive symptoms is much more advisable in order to halt the progression of anxiety symptoms. Early evaluation and treatment of pre-existing depression among individuals with anxiety can also lead to better outcomes in anxiety treatment. Furthermore, students who had witnessed the murder of family members or friends were found to be twice as likely to have anxiety compared to those who had not experienced such traumatic events. This finding is consistent with previous studies (<xref ref-type="bibr" rid="B65">65</xref>&#x2013;<xref ref-type="bibr" rid="B67">67</xref>, <xref ref-type="bibr" rid="B73">73</xref>&#x2013;<xref ref-type="bibr" rid="B75">75</xref>), indicating that trauma can affect brain regions involved in fear regulation and stress responses, increasing the risk of developing anxiety, and this would be more profound when trauma occurred during child and adolescent periods (<xref ref-type="bibr" rid="B76">76</xref>). Another possible reason for this may be the enduring impact of traumatic events, which can continue to affect individuals long after the initial trauma. The development of intense feelings of fear and a sense of powerlessness during traumatic experiences can later manifest as anxiety (<xref ref-type="bibr" rid="B77">77</xref>). This highlights the crucial importance of effectively managing trauma-related events, particularly in children and adolescents, to address and mitigate the risk of anxiety. The study also revealed that female students had 1.6 times- higher risk of anxiety compared to male students. This finding is supported by a number of studies (<xref ref-type="bibr" rid="B33">33</xref>, <xref ref-type="bibr" rid="B38">38</xref>, <xref ref-type="bibr" rid="B41">41</xref>, <xref ref-type="bibr" rid="B48">48</xref>, <xref ref-type="bibr" rid="B65">65</xref>, <xref ref-type="bibr" rid="B78">78</xref>&#x2013;<xref ref-type="bibr" rid="B81">81</xref>) and could be due to the combination of lower stress resistance and higher household workloads typically borne by women compared to men (<xref ref-type="bibr" rid="B82">82</xref>, <xref ref-type="bibr" rid="B83">83</xref>). Additionally, the hormonal changes experienced during puberty, including menstruation, may elevate the likelihood of anxiety in women (<xref ref-type="bibr" rid="B82">82</xref>). Moreover, the increased prevalence of domestic violence among women compared to men could contribute to increased susceptibility to anxiety (<xref ref-type="bibr" rid="B83">83</xref>). Therefore, it is important to address these factors and reduce the burden of household work for women. Lastly, students with a family history of mental illness were 1.7 times more likely to have anxiety compared to those without a family history. This finding is supported by various studies (<xref ref-type="bibr" rid="B43">43</xref>, <xref ref-type="bibr" rid="B78">78</xref>, <xref ref-type="bibr" rid="B84">84</xref>, <xref ref-type="bibr" rid="B85">85</xref>) and can be explained by increased stress and potential abuse within a family affected by mental health problems (<xref ref-type="bibr" rid="B86">86</xref>). Genetic predisposition (<xref ref-type="bibr" rid="B44">44</xref>) and limited caregiver interaction with others due to stigma and caregiving responsibilities may also contribute to a higher risk of anxiety among individuals with a family history of mental illness (<xref ref-type="bibr" rid="B87">87</xref>).Therefore, recognizing these potential hazards and taking proactive measures such as seeking professional assistance, adopting relaxation techniques, and adopting a healthier lifestyle can help reduce the risk of anxiety in these individuals (<xref ref-type="bibr" rid="B88">88</xref>).</p>
</sec>
</sec>
<sec id="s5" sec-type="conclusions">
<title>Conclusions and recommendations</title>
<p>This study revealed that approximately two in five of the high school students in the sample had anxiety symptoms. This study additionally revealed that anxiety symptoms were higher in students with depression, those who had a family history of mental illness, who had been exposed to traumatic events through witnessing the murder of family members or friends, and among female students. Therefore, we recommend that the Ministry of Education work with the Ministry of Health to extend and implement mental health services in high schools and to promote the wellbeing of students in order to prevent anxiety. In addition, we recommend that future researchers work to deal with these population groups as well as identify cause-and-effect relationships among the study variables.</p>
<sec id="s5_1">
<title>Strengths and limitations of this study</title>
<p>This study was conducted with some strengths and limitations. To the best of our knowledge, this study was the first to consider high school students who have a history of experiencing war trauma and deal with its effects on the anxiety symptoms of high school students in the study area. Since it was a cross-sectional study, it could be difficult to declare a cause-and-effect relationship between anxiety symptoms and independent factors such as depression and the dependent variable anxiety symptoms; additionally, recall bias may have occurred during data collection since the study collected retrospective data for 1 year. In addition, locally and culturally developed tools were used to assess anxiety and other independent variables in this study; this may have overestimated or underestimated the prevalence rate (<xref ref-type="bibr" rid="B89">89</xref>).</p>
</sec>
</sec>
<sec id="s6" sec-type="data-availability">
<title>Data availability statement</title>
<p>The original contributions presented in the study are included in the article/supplementary material. Further inquiries can be directed to the corresponding author.</p>
</sec>
<sec id="s7" sec-type="ethics-statement">
<title>Ethics statement</title>
<p>This study was ethically approved by The Institutional Review Board (IRB) of the University of Gondar. This study was conducted in accordance with the local legislation and institutional requirements. Written informed consent for participation in this study was provided by the participants&#x2019; legal guardians/next of kin.</p>
</sec>
<sec id="s8" sec-type="author-contributions">
<title>Author contributions</title>
<p>MK: Conceptualization, Data curation, Formal analysis, Writing &#x2013; original draft, Writing &#x2013; review &amp; editing. TA: Conceptualization, Data curation, Writing &#x2013; original draft. GN:&#xa0;Conceptualization, Data curation, Writing &#x2013; original draft. MM: Conceptualization, Data curation, Writing &#x2013; review &amp; editing. MA: Data curation, Formal analysis, Writing &#x2013; review &amp; editing. ES: Conceptualization, Writing &#x2013; original draft, Writing &#x2013; review &amp; editing. BA: Conceptualization, Data curation, Writing &#x2013; original draft, Writing &#x2013; review &amp; editing.</p>
</sec>
</body>
<back>
<sec id="s9" sec-type="funding-information">
<title>Funding</title>
<p>The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.</p>
</sec>
<ack>
<title>Acknowledgments</title>
<p>We would like to express our thanks to the University of Gondar for giving us the chance to conduct this research. The appreciation of the authors also goes to the study participants, data collectors, and supervisors.</p>
</ack>
<sec id="s10" sec-type="COI-statement">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec id="s11" sec-type="disclaimer">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
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