Research progress on the psychological burden and intervention measures in cancer patients

In the past 40 years, the gradually increasing incidence and mortality rates of malignant tumors have severely impacted the quality of life of patients, bringing significant physical and psychological burdens and becoming an increasingly serious social issue. With the development of medical standards, new methods for cancer detection and treatment have been continuously proposed. Although it has been proven that cancer is related to increased psychological burden and suicidal behaviors in patients, current research on the psychological burden caused by cancer is insufficient. Clinicians often overlook the psychological health issues of patients while treating their physical diseases. Considering the high incidence of cancer, this review will outline the psychological burdens of cancer patients worldwide in recent years and its high-risk factors. Moreover, this review will summarize the common methods for evaluating psychological burdens, present current predictive models and treatment methods for the psychological burden of cancer patients, aiming to provide a research basis and future direction for the timely and accurate assessment of the psychological burden in cancer patients.


Introduction
Nowadays, the incidence and mortality rates of cancer worldwide are showing a continuous upward trend, becoming a severe social issue in the context of increasing average lifespans.There are approximately 19 million to 20 million new cancer cases annually worldwide, with deaths reaching around 10 million.In China, the annual number of new cancer cases among people over 60 years old is about 2,790,000 (1,2).Additionally, the World Health Organization (WHO) predicts that by 2045, the global number of new cancer cases will reach 32.6 million, with an estimated 16.9 million deaths.Due to the rising incidence and mortality rates of cancer, researchers have invested considerable resources in related fields such as cancer diagnosis, treatment, prevention, and prognosis.Personalized treatment plans have been proposed based on different cancer origins, disease stages, and genetic phenotypes, significantly improving the 5-year survival rate of cancer patients (3).However, compared to cancer diagnosis and treatment, the important health issue of cancer patients' psychological burden has not been adequately studied.Particularly in developing countries, clinicians often neglect patients' mental health, leading to a situation of "treating the body but not the mind" (4).
Since the 1970s, psycho-oncology, as a new interdisciplinary field, has become part of cancer treatment.Being diagnosed with cancer often causes patients to lose their life goals and changes their self-and social perceptions, leading to mental distresses such as fear, anxiety, depression, and demoralization, especially in patients with underlying mental illnesses (5).Studies indicate that 35%-52% of cancer patients experience a high psychological burden (6).Excessive psychological burden can induce a series of symptoms and signs, including insufficient rest, dry mouth, and difficulty breathing, which not only affect the prognosis of cancer but may even lead to self-injurious and suicidal behaviors in patients (7).Therefore, screening for the psychological burden of cancer patients as part of routine cancer diagnosis and treatment to implement timely and effective psychological interventions can help improve the prognosis of cancer patients and prevent extreme behaviors.
This review outlines the common psychological burdens and corresponding symptoms in patients diagnosed with cancer, introduces common high-risk factors affecting the mental health of cancer patients; at the same time, we summarize the current common assessment methods and predictive measures, treatment methods for the psychological burden in cancer patients, and discuss the future direction of psycho-oncology and the obstacles to be overcome (Figure 1).

Overview of psychological burden in cancer patients
Cancer patients often present psychological disorders after diagnosis, during and after the treatment such as adjustment disorders, anxiety, affective disorders, demoralization, and posttraumatic stress disorder.In this section, we will summarize and discuss four common psychological burdens experienced by cancer patients: adjustment disorders, anxiety, depression, and demoralization.Additionally, we will introduce changes in the psychological states of patients during the unique period of the COVID-19 pandemic.

Adjustment disorders
In 2018, WHO updated the definition of adjustment disorders as adverse reactions to stressors (such as a cancer diagnosis, setbacks in family and career, etc.) within one month of encountering the stress (8).Adjustment disorders are usually temporary, and people gradually return to a healthy state over time.However, if this state persists, it can induce more severe psychological issues in the patient, such as depression and anxiety, and even lead to suicide (9).Studies show that health-related stressors are significant risk factors for inducing adjustment disorders, which are common among cancer patients, with 13%-30% possibly experiencing them (10)(11)(12).Evaldas et al. conducted a 12-month follow-up on prostate cancer patients, finding that the incidence of adjustment disorders was 15% at the time of cancer diagnosis, 13% three months after diagnosis, and 3% twelve months after diagnosis, showing a declining trend over time (13).It is noteworthy that the incidence of adjustment disorders appears to vary among different types of cancer.According to a study by Dai et al., only 6% of 6,392 newly diagnosed breast cancer patients exhibited adjustment disorders (14).In contrast, 14% of adolescent cancer patients (15) and 16.5% of head and neck cancer patients (16) were found to have adjustment disorders, which is significantly higher than in breast cancer patients.The tumor-specific nature of adjustment disorders may be related to factors such as the treatment modalities, age at diagnosis, and prognosis of the tumor (13-17).Additionally, the variety of methods used to assess and diagnose adjustment disorders can lead to significant differences in the reported incidence rates among different studies (18).

Anxiety
Anxiety is defined as worry about future misfortune and danger, accompanied by restlessness and tense somatic symptoms.Anxiety can cause symptoms including palpitations, sweating, sleep disorders, and seeking comfort.Although anxiety is common in cancer patients, some exhibit overwhelming symptoms, potentially leading to an overestimation of negative cancer prognoses and severely affecting daily life (7).Naser et al. conducted psychological assessments on 1,011 cancer patients (including 612 outpatients and 399 inpatients), finding an anxiety symptom incidence of approximately 19.1%-19.9%,occurring more frequently among inpatients (16).The systematic review of Mohammad et al. showed that cancer patients' average death anxiety score was 6.84, with Asians and young women with breast cancer showing more pronounced death anxiety (19).Sleep disorders, a common symptom of anxiety, affect 33%-50% of cancer patients, and many cancer survivors report it as one of their most common current problems (20).A follow-up of 2,611,907 cancer patients indicated that their anxiety symptoms were positively correlated with specific mortality rates and negatively correlated with cancer survival rates.Additionally, anxiety disorders are positively correlated with cancer incidence (21).

Depression
Previous research indicates that the prevalence of depression in cancer patients is 2-3 times higher than in the general population, and patients' depression symptoms often coexist with anxiety and adjustment disorders (16).In a cross-sectional study, 21.5% of cancer patients undergoing radiotherapy or chemotherapy exhibited depressive symptoms (22).Nineteen percent of longterm cancer survivors have moderate to severe depression symptoms, with higher levels observed in women and younger patients in their working years.There is no significant difference in depression rates between 5-year and 10-year survivors (23).Breast cancer patients, in particular, show a higher proportion of depression symptoms, up to 66%-68.6%, with long-term survivors having higher depression scores five years after diagnosis compared to 40 weeks (24)(25)(26).A cross-sectional study in China indicated that 65.21% of oral cancer patients also show depression symptoms (27).Huang et al.'s study on the psychological burden of non-small cell lung cancer patients in northern China showed that 38.3% of patients exhibit depression symptoms, compared to 10% in the general population (28).The systematic review of Oliver et al. on prostate cancer patients revealed that only 5.81% had depression, 17.07% exhibited depressive symptoms, and 9.85% had suicidal thoughts, with a suicide rate of 47.1 per 100,000 person-years (29).

Demoralization
Demoralization is a manifestation of psychological stress, typically characterized by helplessness, hopelessness, and loss of meaning and goals in life, varying from depression to despair.It is commonly found in patients with progressive diseases and cancer (30).In mainland China, clinicians often conflate demoralization with depression, but unlike the lack of pleasure in depression, patients with demoralization syndrome can still experience happiness.Reports suggest that demoralization is more common than depression in cancer patients and more closely associated with suicidal intentions (31,32).The systematic review of Lin et al. indicated that about 25.98% of cancer survivors experience demoralization, with breast cancer patients scoring higher than others (32).A cross-sectional study in China found that over half of the patients in Xiamen showed signs of demoralization which may be related to living standards, family income, etc. (33).Demoralization often occurs in advanced cancer patients.Garzoń's study indicated that 53.4% of advanced cancer patients exhibited demoralization, with 16% moderate and 37.4% severe (34).Notably, not only advanced cancer patients but also their family members show signs of demoralization.Reports suggest that the family members of terminal cancer patients have an average demoralization score of 29.04, with 39% of caregivers experiencing severe demoralization (35).

Psychological burden of cancer patients during the COVID-19 pandemic
Since late 2019, the COVID-19 pandemic has swept across the world, with most countries implementing lockdown measures during the outbreak.Changes in lifestyle not only affected physical health but also significantly increased psychological burden.Reports indicate that cancer patients are a high-risk group for COVID-19 infection, with depression, anxiety, insomnia, post-traumatic stress disorder being the main psychological issues during the pandemic (36).Wang et al. conducted a cluster sampling study to analyze the psychological burden of cancer patients during the pandemic, finding that among 6,213 patients, 23.4% exhibited depression, 17.7% anxiety, 9.3% posttraumatic stress disorder, and 13.5% hostility (37).Cancer-related treatments, such as chemotherapy, cause immunosuppression in patients, increasing the risk of COVID-19 infection.A study investigating the psychological state of breast cancer patients Monitoring and intervention methods for the psychological burden of cancer patients in the new era.Using an artificial intelligence platform, a predictive model of psychological burden is constructed based on the risk factors identified in cancer patients.Clinical practitioners can achieve rapid assessment and timely intervention for the psychological burden of cancer patients based on the actual conditions of patients and with the aid of artificial intelligence.
during and after chemotherapy showed that 44.4% of them exhibited significant levels of anxiety, 41.7% insomnia symptoms, and 52.8% fear of cancer recurrence, with most (63.9%)experiencing at least one COVID-19 related stressor (38).A prospective trial investigating the psychological burden of lymphoma patients found that 36% of the patients exhibited anxiety symptoms, 31% depression symptoms, 36% post-traumatic stress disorder, with the fear of hospital-acquired COVID-19 infection and treatment interruption being their main concerns (39).

Factors influencing the psychological burden of cancer patients
The psychological burden of cancer patients is influenced by multiple factors.This section summarizes the high-risk factors for psychological issues in cancer patients from three aspects: physical factors of the patient, personal factors, and social factors.

Physical factors
Factors such as the primary site of the tumor, treatment, clinical staging, changes in appearance, and functional impairment in cancer patients have all been proven to correlate with the severity of their psychological burden.The systematic review by Riedl et al. pointed out that physical factors like the stage of the disease, symptoms caused by cancer treatment (such as fatigue, postoperative adverse reactions, uroclepsia), patient's comorbidities, severity of pain, and adjuvant therapy, can increase the risk of depression in patients (40).A crosssectional study compared the self-assessed physical and psychological health status of ovarian cancer patients with recurrence to those without recurrence.The results showed that 59.5% of recurrent patients reported that psychological factors limited their activities, which was significantly higher than the 15.8% of patients without recurrence (41).Studies have indicated that cancer recurrence is a risk factor for emotional disorders (OR=40), adjustment disorders (OR=3.51),and anxiety (OR=6.58) in cancer patients (42).Additionally, based on the SEER database, Rieke et al. noted that the staging of the disease in head and neck cancer patients also impacts their psychological burden.Among those with depression, 19.2% were in the advanced stages of the disease, compared to only 13.3% of nondepressed cancer patients in the advanced stages of head and neck cancer (43).The impact of psychological burden in cancer patients exhibits a clear cancer-type specificity.Statistics show that inpatients are more likely to experience psychological issues compared to outpatients.Among inpatients, depression symptoms are more common in bladder cancer patients, while lung cancer patients exhibit more common anxiety symptoms; among outpatients, breast and prostate cancer patients are more likely to experience depression and anxiety symptoms, respectively (16).The extent of psychological burden in different types of cancer patients also changes with the duration since diagnosis.Manne et al. pointed out that the psychological resilience of patients with gynecological cancers decreases over time from diagnosis, with an increasing psychological burden (44); whereas in liver cancer patients, the psychological burden decreases over time from diagnosis (45).This phenomenon is also related to the different physical burdens of various types of cancer at different times post-diagnosis.In lung and colorectal cancer, significant complications such as sleep disturbances and pain mainly occur within the first 16 months after diagnosis; in contrast, in breast cancer, over half (61%) of long-term survivors diagnosed for more than five years' experience severe pain, fatigue, and sleep disturbances, exacerbating their psychological burden (46).
Malignancies such as head and neck cancer, due to their unique tumor site and surgical treatment modality, have unique risk factors on the psychological burden of patients.For example, concerning changes in appearance, 13%-20% of head and neck cancer patients experience distress related to their appearance, which is positively correlated with the occurrence of depression symptoms (47).Additionally, Lee et al. conducted a cross-sectional study on 52,164 head and neck cancer patients, finding that locations such as the nasopharynx and hypopharynx, due to their severe impact on patients' swallowing and respiratory functions, lead to more frequent psychological issues, with 29.9% of patients experiencing psychological problems, an increase of about 9% compared to before their diagnosis (48).Similar to patients with head and neck cancer, elderly prostate cancer patients who underwent prostatectomy show a significant positive correlation between postoperative psychological burden and uroclepsia (49).The use of androgen deprivation therapy in the treatment of prostate cancer also increases the risk of depression (50).

Personal factors
Demographic factors such as gender, age, and religious beliefs are common predictors in research on the psychological burden of cancer patients.Reports indicate that being female is a risk factor for psychological issues in cancer patients, with male patients having a 71% and 59% lower risk of developing depression and anxiety symptoms, respectively, compared to females (45,51).However, some studies suggest that compared to the same age group in the general population, male cancer patients exhibit a significantly higher proportion of symptoms like depression, anxiety, and difficulty breathing than female patients (52).Regarding the relationship between age and psychological burden in cancer patients, the correlation exists, but the specific outcomes are not definite: many studies show that younger patients are more likely to experience psychological issues (53)(54)(55).However, other research indicates that cancer patients over 85 years old are more likely to suffer from depression than younger patients, possibly due to more severe complications in older adults; whereas young cancer patient groups exhibit a higher frequency of anxiety symptoms compared to the elderly, possibly related to better emotional regulation in older adults (56).Research has shown that religious beliefs can promote the mental health of cancer patients and reduce their pain (57).Tsaras et al.'s cross-sectional study pointed out that non-Orthodox believers among breast cancer patients are a predictor of psychological issues (58).Guan et al. found that in Malaysia, the depression and anxiety of cancer patients are negatively correlated with private participation in religious activities.Patients can use their faith to combat the shock of a cancer diagnosis, reducing thoughts of pain and extreme behavior (59).Evangelos et al. noted that religious beliefs are closely linked to the psychological resilience of cancer patients and are an important predictor of resilience.Many late-stage breast cancer patients seek psychological comfort at the end of their lives by believing in God's healing powers.Religious faith can provide social support for cancer patients, helping them adjust their mindset promptly and face the disease positively (60).
The psychological burden of cancer patients, apart from being influenced by demographic factors, is also related to pre-diagnosis mental health issues.Bouras et al.'s study using logistic regression analysis showed that patients undergoing esophageal and gastric cancer surgery with preoperative mental illness have a significantly increased risk of postoperative depression or anxiety, with an odds ratio (OR) of 6.73 (61).Saboonchi et al. pointed out that pre-surgery life stress in breast cancer patients also increases the likelihood of postoperative anxiety and depression (with an OR of 3.53) (62).Conversely, patients with optimistic and easy-going traits have a higher quality of life after being diagnosed with cancer, thus reducing their psychological burden (63-65).

Social factors
Social support refers to the care and assistance perceived and felt by an individual, provided by their social network and close partners.It is generally divided into instrumental support (concrete assistance) and emotional support (psychosocial help).It has been reported that both effective information provision and emotional support can alleviate the psychological burden of cancer patients (66).
On one hand, in terms of effective information acquisition: a psychological study of newly diagnosed esophageal and gastric cancer patients showed that the time interval between cancer diagnosis and decision on treatment plan for patients without a history of mental disorders is related to the frequency of psychiatric hospital visits within a year after diagnosis.A longer wait for treatment (30-60 days) compared to timely determination of treatment plans (18-29 days) significantly increases the risk of psychological disorders (67).Most cancer patients begin seeking disease-related information such as cancer treatment strategies and common treatment adverse events after diagnosis, to achieve timely and accurate treatment of cancer.The acquisition of this effective information is usually related to the professionals and volunteers that cancer patients can access.Consequently, researchers have investigated the economic and social factors like place of residence, economic conditions, and education level of cancer patients in relation to their psychological burden.Reports indicate that being a rural resident, receiving less than 8 years of education, low social support, and low income are associated with OR of depression symptoms of 1.14, 1.97, 2.84, and 4.41, respectively.Additionally, high social support is closely related to a higher quality of life for patients (42,49,68,69).
In addition, interpersonal relationships of cancer patients also impact their psychological burden.Reports suggest that the psychological burden of elderly cancer patients is significantly related to their marital status and cohabitants.Widowed patients bear a higher psychological burden, while those living with spouses and children have the lowest burden.Patients living only with their children show the highest psychological burden (70).In malignancies like glioma, colorectal, and breast cancer, factors such as being single, divorced, or widowed have been proven to be independent risk factors for depression (71)(72)(73).Notably, Shi et al. points out that in breast cancer patients, high-quality intimate relationships (dependence relationships formed between cancer patients and their spouses in coping with the disease) may be detrimental to post-traumatic growth (b= -0.309 in the structural equation model).This might be because spouses of patients with high-quality intimate relationships tend to hide or deny cancerrelated worries, increasing mutual suspicion (74).

Modern assessment and intervention for psychological burdens in cancer patients
For cancer patients receiving treatment, the timely and accurate identification of their psychological problems by oncologists is a prerequisite for intervening in their psychological burden.Furthermore, with the continuous development of computer technology and artificial intelligence in medical assistance, monitoring of psychological issues in cancer patients has become more convenient and efficient.This section will focus on the current research progress in traditional assessment methods and monitoring tools for psychological burden in cancer patients and summarize common intervention measures from both personal and hospital perspectives.

Assessment methods for psychological burden in cancer patients
Unlike organic diseases, which can be diagnosed using imaging studies, physiological biochemical tests, and pathological examinations, the assessment of psychological burden in the cancer population is mainly based on scales (Table 1).The Center for Epidemiologic Studies Depression Scale (CES-D) is widely used to assess depression symptoms in cancer patients, covering 20 items across four dimensions: depressive affect, positive affect, somatic symptoms, and interpersonal relationships.Several studies have demonstrated good internal consistency and repeatability of the CES-D scale in assessing depression symptoms in various cancer patient populations (75,76,100).The Patient Health Questionnaire-9 (PHQ-9) includes 9 items and is more convenient and time-saving for cancer patients compared to longer scales.It has been reported that the optimal cut-off point for the PHQ-9 scale is ≥9, with a sensitivity of 88% and specificity of 80% (79).The State-Trait Anxiety Inventory (STAI) is a 40-item self-report scale used to assess and differentiate between state and trait anxiety; its revised version, STAI-Y, reduces overlap with depression.Studies have shown that the STAI-Y scale with a cut-off point >23 has a sensitivity of 94.3% and specificity of 93.6% (101).The Hospital Anxiety and Depression Scale (HADS) consists of 14 items, including two subscales for anxiety and depression (HADS-A, HADS-D), mainly used for screening anxiety and depression symptoms in hospital patients in non-psychiatric settings (102,103).According to studies, the optimal cut-off point for HADS-A is >9, with a sensitivity of 83.2% and specificity of 80.5%; for the HADS-D scale, the optimal cut-off point is >7, with a sensitivity of 72.9% and specificity of 79% (103).However, Hartung et al. compared the HADS and PHQ-9 scales and found that their accuracy in diagnosing severe depression is comparable and lower than previously reported.These scales have limited screening capacity for depression compared to standardized diagnostic interviews, potentially leading to false-positive cases (104).Moreover, for the assessment of demoralization in cancer patients, the common scale used is the revised Demoralization Scale (DS-II).
The DS-II scale has 16 items covering two subscales, including meaning and purpose, distress and coping ability.The Cronbach's a coefficient of the DS-II scale is reported to be 0.93, indicating excellent internal consistency (92).It is important to note that detecting psychological problems in cancer patients today is quite challenging, as cancer symptoms often overlap with psychological issues causing fatigue, loss of appetite, sleep disturbances, etc.Additionally, due to shame in facing their psychological issues and an attitude of protecting privacy, patients may not truthfully fill out their psychological conditions in surveys (105,106).Therefore, seeking new ways to screen patients' psychological burdens is crucial to accurately and timely intervene and treat their psychological distress.

Artificial intelligence predictive models for psychological burden in cancer patients
With the development of computer technology, AI is increasingly applied in the diagnosis and treatment of tumors.However, in the identification and prediction of the psychological burden of cancer patients, AI is still in its infancy, and the field holds significant research value.Susheela et al., based on the PHQ-9 depression scale and GAD-7 anxiety scale, assessed the risk factors of psychological burden in female ovarian cancer patients using common machine learning techniques such as random forests, linear support vector machines, and artificial neural networks, and constructed predictive models for depression and anxiety in ovarian cancer patients.The study showed that the accuracy rates of the linear support vector machine for depression and anxiety were 91.52% and 93.78%, respectively (107).In addition to using scales, AI can also assess patients' psychological burdens through means such as facial expressions (e.g., reduced facial activity, avoiding eye contact) and voice data (e.g., slower speech, pauses in speaking, increased usage of first-person pronouns) (108).Chen et al. developed a method to identify the psychological burden of cancer patients using a machine learning model based on facial expression features, verifying that the model's accuracy could reach 82%-93.3%,demonstrating the immense potential and significant role of patient facial expressions in predicting psychological burden (109).To reduce the tedium of patients using questionnaires to assess psychological burden during medical visits, Zhang et al. proposed a cohort study plan to recognize the psychological burden of adolescent and young cancer patients based on voice recognition.The project plans to use the Ellipsis Health voice tool (EH) for a 6-month mental stress monitoring of patients aged 15 to 26.Unfortunately, the results of this project have not yet been made public (110).Additionally, the structure and function of the brain are important biomarkers for identifying mental disorders, so AI processes and analyzes patients' neuroimaging data (such as MRI, EEG) for predictive purposes in mental illness (111,112).Research indicates that in resting-state functional MRI and diffusion tensor imaging results of rectal cancer patients, those with depressive tendencies show impairment in the functional and structural networks of the brain (113).More importantly, unlike patients' reluctance to reveal their true condition when using traditional psychological assessment scales, according to Lucas et al.'s study, patients are more willing to self-disclose when interacting with computer-simulated humans, without worrying about the negative impact of their responses (114).

Treatment methods for psychological burden in cancer patients
Many cancer patients' psychological problems are not timely discovered or intervened in.Jansen et al. pointed out that in the Netherlands, only 5%-9% of head and neck cancer patients used psychological care services at each time point from diagnosis to two years after treatment (115).Currently, there is no consensus on the management and treatment of psychological burden in cancer patients, but the mainstream methods can be roughly divided into hospital-level psychological therapy and social-level psychological care for cancer survivors.Systematic reviews indicate that the quality of clinical trials on the use of antidepressants for depression symptoms in cancer patients is poor, and there is no significant difference in efficacy between antidepressants and placebos in treating depression (116).Zetzl et al. introduced a yoga therapy program where breast cancer and guidance-oriented physical therapy in addition to routine care between 4 weeks and 6 months after radiotherapy.The study found that the intervention group showed higher fighting spirit than the control group six months after radiotherapy, and significantly lower cognitive avoidance three years later (122).Overall, in the future, clinicians should formulate treatment guidelines for the psychological burden of cancer patients based on larger-scale, more technologically advanced, and more rigorous clinical trials, to achieve multidisciplinary and multidimensional comprehensive management of the psychological burden in cancer patients.

Conclusion and outlook
Nowadays, psychological issues among cancer patients are becoming increasingly frequent.Cancer not only devastates the physical body but also shackles the mental world of patients.Fortunately, more and more healthcare professionals and social workers are starting to pay attention to the psychological burden of cancer patients.An increasing number of high-quality and rigorous clinical studies are being conducted to seek out the risk factors and effective intervention measures for the psychological burden of various types of cancer patients, aiming at early prediction and timely intervention of psychological issues.Compared to the general population, cancer patients have a significantly higher probability of experiencing psychological disorders such as depression, anxiety, demoralization syndrome, and adjustment disorders.In general, the psychological burden of cancer patients is related to multiple factors, including the type of cancer, cancer staging, the timing of cancer diagnosis, gender, age, and family income.However, there are currently many types of assessment scales for psychological issues, which are time-consuming to fill out.At the same time, there are various methods, including cognitive therapy, art therapy, and AI involvement, to intervene in the psychological burden of cancer patients.Still, the proportion of cancer patients with psychological issues who receive timely and effective psychological treatment is not as satisfactory as might be expected.
Therefore, in future research, considering the specificity of cancer types, researchers could leverage the advantages of machine learning to construct targeted predictive models for the psychological burden of cancer patients.Moreover, since patients often feel less ashamed discussing their conditions with machines compared to clinical physicians, this significant advantage can be utilized.Artificial intelligence can assess patients' psychological health accurately and rapidly during their initial visits by evaluating objective parameters such as facial expressions, speech patterns, blood pressure, heart rate, and electroencephalograms (EEGs), thus minimizing the impact of subjective factors that may occur during self-assessment surveys and interviews.Apart from monitoring psychological issues in cancer patients, designing rigorous, larger sample size, and focused clinical trials on the prevention and intervention of psychological burden should also be implemented to achieve a comprehensive understanding and control of the psychological burden in cancer patients.With the cooperation of cancer patients, their families, oncology healthcare professionals, psychiatrists, and social workers, cancer patients will not only receive physical treatment but also more attention and assistance for their psychological burden.

TABLE 1 Psychological
Burden Assessment Scales for Cancer Patients.