AUTHOR=Ding Mubing , Zhang Shaotong , Zhu Zaochen , Cai Renliang , Fang Jin , Zhou Chao , Zhang Xiangrong , Fang Xinyu 

TITLE=Influencing factors of different metabolic status in hospitalized patients with schizophrenia

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1436142

DOI=10.3389/fpsyt.2024.1436142

ISSN=1664-0640

ABSTRACT=The aim of this study was to explore the risk factors for different metabolic status in patients with schizophrenia. Methods: A total of 968 hospitalized patients with schizophrenia were recruited. Fasting blood glucose (GLU) and lipid profile, including total cholesterol (TC), lowdensity lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) were measured. Schizophrenia patients were divided into four groups: normal metabolism and weight (NMNW), abnormal metabolism and normal weight (AMNM), normal metabolism and overweight/obesity (NMO), and abnormal metabolism and overweight/obesity (AMO). Results: Our results showed NMNW, AMNW, NMO and AMO accounted for 25.3%, 12.7%, 25.4% and 36.6%, respectively. There were significant differences in age, disease during, BMI, waist circumference, chronic disease, SBP, DBP, GLU, TG, TC, HDL-C and LDL-C among these four groups (all P < 0.05). With NMNW group as the reference, the disordered multiple classification regression analysis showed that chronic disease was a significant risk factor for AMNW (OR = 5.271, 95% CI = 3.165 to 8.780, P < 0.001) and AMO (OR = 3.245, 95% CI = 2.004 to 5.254, P < 0.001), age was an important protective factor for NMO (OR = 0.968, 95% CI = 0.943 to 0.994, P = 0.015) and AMO (OR = 0.973, 95% CI = 0.948 to 0.999, P < 0.042), waist circumference was a significant risk factor for NMO (OR = 1.218, 95% CI = 1.180 to 1.257, P < 0.001) and AMO (OR = 1.252, 95% CI = 1.212 to 1.291, P < 0.001), and college education was an obvious protective factor for AMO (OR = 0.343, 95% CI = 0.123 to 0.953, P < 0.040) among patients with schizophrenia.The findings of our study underscored the importance of factors such as age, education level, chronic disease and waist circumference when exploring the influencing factors and biological mechanisms of obesity-related metabolic problems in schizophrenia patients.