AUTHOR=Lai Pengwei , Xie Xingyun , Zeng Wen , Cheng Weiwen , Liu Xinyuan , Long He , Peng Taierqi , Hu Antong , Du Xiaohong 

TITLE=Relationship between uric acid and depression in American adults: findings from NHANES, 2005-2020

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1544266

DOI=10.3389/fpsyt.2025.1544266

ISSN=1664-0640

ABSTRACT=BackgroundAt present, the role of uric acid in mental disorders is receiving increasing attention, but its relationship with depression is controversial, and previous studies have corresponding limitations. The relationship between them has not been fully elucidated.ObjectiveThe purpose of this study is to explore the relationship between uric acid and depression in American adults using data from the National Health and Nutrition Examination Survey (NHANES).MethodsThis cross-sectional study included participants from the National Health and Nutrition Examination Survey 2011-2020. Use logistic regression and restricted cubic spline analysis to investigate the relationship between uric acid and depression. The interactions between variables were determined using subgroup analysis and described in a forest plot.Results37033 participants were included in this study, with depression patients accounting for 8.95%. The uric acid levels in the depression group and nondepression group were 317.69 μ mol/L and 323.34 μ mol/L, respectively, with the former having significantly lower uric acid levels than the latter. In the fully adjusted model, participants in the third tertile of uric acid showed a significant correlation (P=0.002, OR; 0.85 (0.76 ~ 0.94)) with a higher risk of depression compared to participants in the first tertile. There is an approximately linear negative correlation between uric acid and depression (P for nonlinear=0.360), and the OR value of uric acid is 1 when the uric acid value is 312.20 μ mol/L.ConclusionsCurrent research suggests that serum uric acid is associated with depression in American adults. More discoveries and causal relationships require further investigation.