AUTHOR=Trieu Calvin , van Leeuwenstijn Mardou S. S. A. , Schlüter Lisa-Marie , Ebenau Jarith L. , Verberk Inge M. W. , Sikkes Sietske A. M. , Verfaillie Sander C. J. , van de Giessen Elsmarieke , Teunissen Charlotte E. , van der Flier Wiesje M. , van Harten Argonde C. 

TITLE=Longitudinal associations between amyloid and symptoms of depression and anxiety in subjective cognitive decline: the impact of personality characteristics

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1572174

DOI=10.3389/fpsyt.2025.1572174

ISSN=1664-0640

ABSTRACT=IntroductionDepressive/anxiety symptoms are common in subjective cognitive decline (SCD) and may relate to Alzheimer’s pathology, potentially modulated by personality characteristics.MethodsDepressive/anxiety symptoms were assessed over 4 ± 2 years in 329 SCD (88 amyloid-positive/241 amyloid-negative) using Geriatric Depression Scale-15 (GDS), Center for Epidemiological Studies-Depression (CES-D), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A). Mixed-effects models assessed associations between amyloid status and these symptoms, with neuroticism and somatization as effect-modifiers.ResultsAmyloid status was not directly associated with GDS, CES-D or HADS-A. However, neuroticism modified the association between amyloid status and GDS (p<0.05). In lower neuroticism, amyloid positivity was associated with GDS increase (β:0.10 ± 0.08), but not in higher neuroticism (β:-0.04 ± 0.12). Somatization modified the association between amyloid status and CES-D (p<0.05). In lower somatization, amyloid positivity was associated with CES-D increase (β:0.65 ± 0.23), but not in higher somatization (β:-0.12 ± 0.29).DiscussionAmyloid-positive individuals with lower neuroticism/somatization increased more in depressive symptoms over time, suggesting a preclinical AD-related depressive phenotype.