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        <title>Frontiers in Psychiatry | New and Recent Articles</title>
        <link>https://www.frontiersin.org/journals/psychiatry</link>
        <description>RSS Feed for Frontiers in Psychiatry | New and Recent Articles</description>
        <language>en-us</language>
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        <pubDate>2026-05-14T09:12:24.77+00:00</pubDate>
        <ttl>60</ttl>
        <item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1795532</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1795532</link>
        <title><![CDATA[Large-scale meta- and cross-trait analyses uncover shared genetic risk factors for IBS and psychiatric disorders]]></title>
        <pubdate>2026-05-14T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Weiyi Ye</author><author>Huanxin Ding</author><author>Bichen Peng</author><author>Xianjin Wang</author><author>Yugang Cheng</author><author>Guangyong Zhang</author><author>Hongwei Yu</author><author>Kalim Ullah</author><author>Xiao Chang</author><author>Xiaoyan Wang</author><author>Zhiyu Wang</author>
        <description><![CDATA[IntroductionIrritable bowel syndrome (IBS) is a common gut-brain axis disorder characterized by abdominal pain and altered bowel habits, and it shows high comorbidity with psychiatric disorders. However, the shared genetic mechanisms underlying these associations remain incompletely understood.MethodsWe performed a large-scale meta-analysis of IBS in individuals of European ancestry by integrating genome-wide association study (GWAS) summary statistics from the UK Biobank, Bellygenes, and the Million Veteran Program (MVP), thereby increasing statistical power to detect novel IBS loci. We further conducted global genetic correlation analyses with psychiatric traits, followed by multi-trait analysis of GWAS (MTAG) and conditional false discovery rate (condFDR) analyses to identify pleiotropic loci. Transcriptomic, methylomic, and expression quantitative trait locus (eQTL) data were integrated to explore potential regulatory mechanisms.ResultsThe meta-analysis identified up to ten previously unreported IBS loci, several of which were supported by colonic and brain eQTL effects. Global genetic correlation analyses confirmed substantial genetic overlap between IBS and psychiatric traits, particularly major depressive disorder and neuroticism. MTAG and condFDR analyses uncovered more than 100 pleiotropic loci, including signals at SORCS1, SLC35D1, COA1, and TLE1. Integrative analyses of transcriptome- and methylome-wide data highlighted regulatory mechanisms spanning colonic, immune, and neuronal tissues, supporting neuro-immune crosstalk and mitochondrial involvement.DiscussionOur findings provide a comprehensive genetic characterization of IBS, refine its heritable basis, reveal pleiotropic links with psychiatric disorders, and implicate molecular pathways across the gut-brain axis. These results advance mechanistic understanding of IBS and may inform future therapeutic development for IBS and its psychiatric comorbidities.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1813727</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1813727</link>
        <title><![CDATA[Recognizing anxiety and depression in cancer patients based on speech and facial expressions]]></title>
        <pubdate>2026-05-14T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Na Xu</author><author>Tao Wu</author><author>Li Sun</author><author>Ping Xin</author><author>Xu Tan</author><author>Na Luo</author><author>Yi Liu</author>
        <description><![CDATA[PurposeTo address the anxiety and depression experienced by cancer patients due to the stress of diagnosis and treatment, as well as the limitations of traditional assessment methods characterized by high subjectivity and low efficiency, this study aims to develop a multimodal fusion approach for the simultaneous and precise evaluation of these two psychological states.Patients and methodsA speech-video dataset of clinically diagnosed cancer patients was used. This study proposes a multimodal fusion approach: for depression recognition, We employ the HuBERT pre-training architecture based on Transformers, integrating specific acoustic features of depression with textual content to achieve accurate classification of depression through a voice-text modality. For anxiety recognition, a multi-task convolutional neural network is designed to infer anxiety status from the facial expressions.ResultsExperiments conducted on a speech-video dataset of clinically diagnosed cancer patients demonstrates that the multimodal fusion model achieves a depression recognition F1 value of 0.85 and an anxiety recognition F1 value of 0.74, significantly outperforming the unimodal model.ConclusionThe results of the two modalities are fused by decision-level weighted averaging to realize the simultaneous assessment of anxiety and depression in cancer patients. The study may provide technical support for rapid, noninvasive screening of psychological status in cancer patients.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1795900</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1795900</link>
        <title><![CDATA[Network structure of non-suicidal self-injury, alcohol and food addiction, and motivation in bus drivers]]></title>
        <pubdate>2026-05-14T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Xun Song</author><author>Wen-wen Miao</author><author>Yang-ying Bu</author><author>Fang Wang</author><author>Hui Zheng</author><author>Yi-fei Li</author><author>Yi-hang Huang</author><author>Qiang Hu</author>
        <description><![CDATA[IntroductionProfessional bus drivers work in a safety-critical, high-demand context that may increase vulnerability to non-suicidal self-injury (NSSI) and addictive behaviors. However, the symptom-level mechanisms underlying this risk remain poorly understood, limiting the development of targeted, occupation-sensitive prevention and intervention strategies.MethodsUsing cluster sampling, 1250 bus drivers were screened in southern Anhui (June 1–July 1, 2023). Participants completed standardized assessments, including a questionnaire based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) proposed criteria for NSSI, the Alcohol Use Disorders Identification Test (AUDIT), the Yale Food Addiction Scale 2.0 (YFAS 2.0), and the Habit, Reward, and Fear Scale (HRFS). We estimated a regularized partial correlation network and constructed Bayesian directed acyclic graphs (DAGs) to examine directional relations.ResultsIn the regularized partial correlation network, Reward and Fear were the most central nodes, showing the highest levels of strength and expected influence. Alcohol addiction was positively associated with food addiction, NSSI, and motivation. In the DAG, Reward and Fear were positioned as putative upstream nodes while AUDIT as a terminal node. Motivation and food addiction symptoms showed direct edges to alcohol addiction, whereas NSSI showed a putative indirect link to AUDIT via YFAS.ConclusionThese results indicate structured interrelations among NSSI, alcohol addiction, food addiction, and motivation in bus drivers, and nominate Reward- and Fear-related processes as promising intervention targets. These insights offer a new perspective on the psychological network underlying risk behaviors in this occupational group and may inform strategies to improve mental health of transportation workers and public transportation safety.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1800009</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1800009</link>
        <title><![CDATA[Cortical high-threshold and low-activation characteristics in adolescent depression: a cross-age differential analysis]]></title>
        <pubdate>2026-05-14T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Jialin Gai</author><author>Duanwei Wang</author><author>Fengya Zhen</author><author>Tao Kong</author><author>Xiuqing Niu</author><author>Xianwei Che</author><author>Shengqiao Wang</author><author>Zhe Liu</author><author>Cuixia An</author><author>Xu Lin</author>
        <description><![CDATA[BackgroundAdolescent depression exhibits distinct neurophysiological features, with marked age heterogeneity particularly in the resting motor threshold (RMT) measured during repetitive transcranial magnetic stimulation (rTMS), and substantial variability in clinical therapeutic efficacy. Functional near-infrared spectroscopy (fNIRS) enables the assessment of cortical excitability levels; however, research investigating the association between RMT and cortical activation in adolescent patients with depression remains limited. This study aims to elucidate the underlying neural mechanisms from the perspective of cortical hemodynamics, which is crucial for further optimizing neuromodulation strategies in patients with depression.MethodsWe collected data from 85 treatment-naive patients with depression who underwent rTMS therapy. All patients completed RMT measurement, fNIRS examination, and Hamilton Depression Rating Scale (HAMD) assessment prior to rTMS treatment. Participants were divided into three groups according to age: the adolescents group (n=31), the young adult group (n=26), and the middle-aged group (n=28). We compared the differences in RMT among the three groups and explored the relationships between RMT, cortical activation (reflected by prefrontal oxyhemoglobin level changes during the verbal fluency task via fNIRS), and depression severity (assessed by HAMD scores).ResultsThe results demonstrated that the adolescents group had a significantly higher RMT than the other age groups (58.00 ± 11.14, P < 0.001), accompanied by the lowest prefrontal Oxy-Hb activation level (0.095 ± 0.06, P < 0.001). A strong negative correlation was observed between RMT and cortical activation (Spearman’s rs= -0.929, P < 0.001), while a strong positive correlation was found between RMT and depression severity (Spearman’s rs = 0.837, P < 0.001). The distinct coupling phenomenon of high threshold-low activation-severe symptoms was most prominently manifested in this age group, which may theoretically reflect an underlying dysregulation in broader emotional networks, though the current direct findings strictly indicate localized alterations in prefrontal activation and motor cortical excitability.ConclusionsThe characteristics of high RMT and low cortical activation in adolescent depression serve as important neurobiological markers for depression severity. This finding provides a novel direction for developing individualized, developmentally tailored neuromodulation strategies (e.g., optimization of rTMS targets and dosages), indicating that interventions for adolescent depression should prioritize promoting the healthy integration of emotional circuits and the functional coordination between the cortex and subcortex.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1847854</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1847854</link>
        <title><![CDATA[Conversational AI for perinatal mental health: promise, limits, and a human-AI stepped-care framework]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Perspective</category>
        <author>Haiyan Yang</author><author>Dong-Mei Lin</author>
        <description><![CDATA[Perinatal mental health conditions are common yet persistently underdetected and undertreated. Recent advances in generative artificial intelligence (AI) and multimodal interaction offer new opportunities for scalable, continuous support, making the concept of the “digital doula” particularly compelling. Because perinatal care relies heavily on emotional support, repeated contact, and timely escalation, conversational AI is attractive as a potential adjunct to existing care. We argue that digital doulas should not be framed as autonomous substitutes for clinicians or human doulas, but rather conceptualized as AI-enabled relational interfaces embedded within a stepped-care model. We propose four core functions for digital doulas: companionship, symptom interpretation, navigation, and sentinel monitoring. These roles can reduce disclosure barriers, extend support between clinical visits, and strengthen linkage to appropriate care. However, conversational AI also introduces significant risks, including the illusion of empathy, crisis recognition failures, algorithmic bias against vulnerable populations, data privacy vulnerabilities, and unsafe deployment. To address these risks, we outline a safety-by-design agenda emphasizing human oversight, clear escalation protocols with medico-legal accountability, workflow integration, and equity-centered evaluation. Ultimately, the clinical value of digital doulas depends on safely strengthening the perinatal mental health care cascade without replacing its core human relationships.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1847115</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1847115</link>
        <title><![CDATA[Internalizing and externalizing pathways to internet gaming disorder: the roles of anger and social anxiety]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Mazen Omar Almulla</author><author>Ahmed Alduais</author><author>Abdullah Ahmed Almulla</author>
        <description><![CDATA[BackgroundInternet Gaming Disorder (IGD) represents a significant behavioral health concern, yet the roles of internalizing and externalizing psychological vulnerabilities in its development remain underexplored, particularly in Arabic-speaking populations.ObjectiveThis study examined anger and social anxiety as distinct externalizing and internalizing predictors of IGD severity in a Saudi Arabian community sample.MethodsA cross-sectional survey was administered to 303 participants (60.1% female; estimated mean age = 29.79 years, SD = 8.83) across five regions of Saudi Arabia. Participants completed the Internet Gaming Disorder Scale–Short Form (IGDS9-SF), a three-item Anger Screening Scale, and a two-item Social Anxiety screener. Hierarchical linear regression and structural equation modeling (SEM) were conducted to examine unique and incremental contributions of anger and social anxiety to IGD symptoms.ResultsAnger and social anxiety were strongly intercorrelated (r = .86, p <.001) but demonstrated divergent patterns in multivariate models. Hierarchical regression indicated that both predictors contributed unique variance when entered simultaneously, with anger positively and social anxiety negatively predicting IGD after controlling for shared variance. However, SEM clarified that only social anxiety significantly predicted latent IGD severity (β = .32, p = .027), whereas anger did not (β = .07, p = .68). The final model explained approximately 13% of variance in IGD symptoms.ConclusionsSocial anxiety was associated with IGD severity as a distinct internalizing correlate, consistent with avoidance-based coping and online social preference accounts. These preliminary, cross-sectional findings suggest that social anxiety warrants consideration in future IGD screening and research efforts in Arabic-speaking contexts.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1780813</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1780813</link>
        <title><![CDATA[Romanian male patients with the dual diagnosis of schizophrenia and alcohol use disorder: a prospective study of clinical, social, and treatment-related factors affecting quality of life]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Antonia Ioana Vasile</author><author>Simona Trifu</author><author>Cristina Alexandra Negoita</author>
        <description><![CDATA[BackgroundSchizophrenia frequently co-occurs with alcohol use disorder (AUD), resulting in a complex clinical profile associated with poor functional outcomes and reduced quality of life (QoL). Although both conditions independently impair psychosocial functioning, few studies have examined the combined effects of clinical, social, and treatment-related factors on QoL in patients with this dual diagnosis.MethodsThis prospective observational study included 88 male inpatients diagnosed with schizophrenia and comorbid AUD and who were followed over a 6-month period. Quality of life was assessed using the World Health Organization Quality of Life–BREF (WHOQoL–BREF). The clinical variables included severity of psychotic symptoms (Positive and Negative Syndrome Scale), alcohol use severity (Michigan Alcohol Screening Test), and treatment characteristics. Social and personal factors, such as self-care capacity, social support, education, and legal problems, were also evaluated. Multivariable regression analyses were conducted to identify predictors of QoL at baseline and follow-up.ResultsAt baseline, higher QoL was significantly associated with greater self-care capacity, social support, and higher positive symptom scores, while the need for antipsychotic treatment was associated with lower QoL. At the 6-month follow-up, better QoL was predicted by greater self-care capacity, higher educational level, and receipt of anti-craving medication. By contrast, negative and general psychopathology, medico-legal problems, and the need for antidepressant treatment were associated with poorer QoL. Alcohol use severity, as measured by the MAST, was not independently associated with QoL at either timepoint.ConclusionsIn patients with schizophrenia and comorbid AUD, QoL is shaped by a complex interaction of clinical severity, functional capacity, and treatment-related factors. Beyond symptom control, interventions targeting self-care, social functioning, and integrated addiction treatment appear essential to improve long-term outcomes. These findings support the implementation of a multidimensional, recovery-oriented approach for the management of patients with the dual diagnosis.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1794219</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1794219</link>
        <title><![CDATA[Relationship between parental marital conflict and malevolent creativity propensity among junior school students: roles of deviant peer affiliation and self-control]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Mingzhe Zhao</author><author>Yan Liu</author>
        <description><![CDATA[This study explored the relationship between parental marital conflict and malevolent creativity propensity among junior school students, as well as the roles of deviant peer affiliation and self-control on that relationship. A sample of 947 junior school students was surveyed using the Children’s Perception of Marital Conflict Scale, Deviant Peers Affiliation Scale, Brief Self Control Scale, and Malevolent Creativity Behavior Scale. The results indicated that parental marital conflict was positively associated with students’ malevolent creativity propensity, and deviant peer affiliation partially mediated the relationship between parental marital conflict and malevolent creativity propensity. In addition, self-control moderated the second stage of the mediation of deviant peer affiliation in the link between parental marital conflict and malevolent creativity propensity. Ecological systems theory, social learning theory, and Self-Determination theory were used to explain our findings, while limitations and future research directions were discussed in detail.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1837161</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1837161</link>
        <title><![CDATA[Development and validation of a machine learning–based risk prediction model for non-suicidal self-injury in adolescents]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Yujun Zhao</author><author>Qian Wang</author><author>Wei Liu</author>
        <description><![CDATA[BackgroundNon-suicidal self-injury (NSSI) among adolescents has long been an important social issue. This study aims to construct a predictive model for NSSI based on machine learning models.MethodsA retrospective cohort study design was adopted, including 588 adolescent patients who received psychological and psychiatric assessments. The occurrence of NSSI behavior was used as the outcome variable. Candidate predictors including demographic characteristics, psychological and emotional status, behavioral characteristics, and peer support were collected. The dataset was randomly divided into a training set and a test set at a ratio of 7:3. By comparing the performance of four machine learning models—multiple logistic regression (MLR), random forest (RF), support vector machine (SVM), and eXtreme Gradient Boosting (XGBoost)—at different time points (T1, T2, T3) using area under the curve (AUC), accuracy, precision, recall, and F1 score, the optimal model was selected. The Shapley additive explanations (SHAP) method was further used to conduct interpretability analysis for the optimal model.ResultsThe incidence rates of NSSI at T1, T2, and T3 were approximately 24%, 23%, and 22%, respectively. The SVM model demonstrated superior discrimination ability and stability in predicting the risk of NSSI among adolescents, with AUC values all greater than 0.75 and recall and F1 scores both higher than 0.7. SHAP analyses at all three time points consistently showed that suicide-related ideation and behaviors, school bullying, and depressive status had high contributions to the prediction of NSSI risk.ConclusionThe support vector machine model performed best in predicting NSSI among adolescents. Suicide-related behaviors are important predictors of NSSI. The findings of this study help improve the early identification of adolescents at high risk of NSSI and provide evidence for developing targeted prevention and intervention strategies.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1799295</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1799295</link>
        <title><![CDATA[Abnormalcerebral-limbic functional connectivity between bipolar mania and bipolar depression under resting state]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Shanghao Yang</author><author>Chang Liu</author><author>Guowei Wu</author><author>Xinchun Li</author>
        <description><![CDATA[ObjectivePrevious research has identified aberrant functional connectivity (FC) in the neural circuits of patients with bipolar mania (BD-M) and bipolar depression (BD-D), yet the specificity of these FC patterns to each mood state remains unelucidated. This study was designed to compare the cerebral-limbic FC characteristics among BD-M, BD-D patients and healthy control (HC) subjects.MethodResting-state functional magnetic resonance imaging (fMRI) was performed on 30 BD-M patients, 31 BD-D patients and 30 HC subjects. Interregional cerebral FC values were calculated for group-wise comparisons, and the correlation between abnormal FC and depressive symptom severity was further explored.ResultsNo significant group differences in cerebral-limbic functional connectivity survived false discovery rate (FDR) correction for multiple comparisons (p<0.05); thus, all reported abnormal FC patterns were identified at a stringent uncorrected statistical threshold of p<0.001 and should be strictly interpreted as exploratory neurofunctional trends without statistical validation at the individual connection level. Abnormal cerebral-limbic FC in the default mode network (DMN), attention network and limbic areas was observed in both BD-M and BD-D groups. Specifically, BD-D patients showed elevated FC mainly in the DMN [posterior cingulate gyrus (PCG), precuneus (PCUN)], attention network [superior parietal gyrus (SPG), inferior parietal gyrus (IPG)] and limbic regions [hippocampus (HIP), parahippocampus (PHG)], while BD-M patients displayed reduced cerebral-limbic FC in the DMN and limbic areas.ConclusionsBD-M and BD-D show distinct and divergent cerebral-limbic FC patterns: reduced DMN FC in BD-M and increased DMN FC in BD-D. These exploratory patterns suggest potential neurofunctional correlates of mood states in bipolar disorder, offering preliminary clues to state-related differences that require validation in larger independent cohorts.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1848536</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1848536</link>
        <title><![CDATA[Editorial: Psychiatric insights in genetic and chromosomal disorders]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Editorial</category>
        <author>Hiroki Ishiguro</author><author>Itaru Kushima</author><author>Jamie K. Capal</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1792299</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1792299</link>
        <title><![CDATA[Cognitive reappraisal mediated the relationship between childhood emotional neglect and suicidality in depressed adolescents and young adults with NSSI behavior]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Keliang Pan</author><author>Tingyu Hu</author><author>Guojian Yan</author><author>Guocheng Zhao</author><author>Yu Wang</author><author>Wanhong Peng</author><author>Zheyu Liu</author><author>Shiya Zhang</author><author>Lan Hu</author>
        <description><![CDATA[BackgroundDepressed adolescents and young adults with non-suicidal self-injury (NSSI) represent a high-risk group for suicide. Childhood trauma is a well-established distal risk factor for suicidality, but the specific associations between trauma subtypes and suicidal ideation, and the underlying psychological mechanisms—particularly the roles of emotion regulation strategies—remain unexplored in this comorbid population.MethodsA cross-sectional study involving 120 depressed adolescents and young adults (aged 11-22) with NSSI was conducted. Participants completed the Childhood Trauma Questionnaire-Short Form (CTQ-SF), the Beck Scale for Suicidal Ideation (BSS), and the Emotion Regulation Questionnaire (ERQ). Pearson correlation and stepwise linear regression analyses were employed to examine relationships between childhood trauma subtypes (emotional abuse, physical abuse, sexual abuse, emotional neglect, physical neglect), emotion regulation strategies (cognitive reappraisal, expressive suppression), and current suicidal ideation. Mediation analysis with 5,000 bootstrap samples was performed to test whether cognitive reappraisal and expressive suppression mediated the link between significant trauma predictor(s) and suicidal ideation.ResultsEmotional neglect (68.3%), emotional abuse (55.8%), and physical neglect (52.5%) were the most prevalent trauma subtypes. Emotional abuse, emotional neglect, and physical neglect were positively correlated with suicidal ideation, while cognitive reappraisal was negatively correlated with both emotional neglect and suicidal ideation. Stepwise linear regression identified emotional neglect as a significant predictor of both lower cognitive reappraisal and higher suicidal ideation. Crucially, cognitive reappraisal partially mediated the relationship between childhood emotional neglect and current suicidal ideation, accounting for 16.9% of the total effect. No significant associations were found for expressive suppression.ConclusionThis study highlights the predominance of emotional maltreatment in depressed youth with NSSI and identifies a specific psychological pathway: childhood emotional neglect contributes to increased suicidal ideation, partially through the impairment of cognitive reappraisal. These findings underscore the clinical importance of assessing emotional neglect and targeting cognitive reappraisal skills in therapeutic interventions aimed at reducing suicide risk in this vulnerable population.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1777647</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1777647</link>
        <title><![CDATA[Perception of social support and psychological well-being among mothers of individuals with intellectual disabilities: the mediating role of self-efficacy]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Fatma Özoğlu</author><author>Emine Öztürk Karataş</author><author>Mehdi Duyan</author><author>Talip Çelik</author><author>Varol Tutal</author><author>Mehmet Ilkım</author><author>Özgür Karataş</author><author>Çetin Tan</author><author>Selçuk Okuyucu</author><author>Yunus Sadır</author>
        <description><![CDATA[BackgroundThe aim of this study is to examine the mediating role of self-efficacy in the relationship between social support perception and psychological well-being among mothers of individuals with intellectual disabilities.MethodsA correlational survey model was used in this study in line with the research objectives. The study group consisted of mothers of individuals with intellectual disabilities (n=80) in two central districts of Malatya province. Convenience sampling was employed in the study. The Psychological Well-being Scale was used to measure the psychological well-being of the participating mothers, the “Perceived Support Scale for Families of Children with Disabilities” was used to measure their perceived levels of social support, and the “Parental Self-Efficacy Scale” was used to measure their self-efficacy. In addition, a personal information form was used to introduce the socio-demographic characteristics of the participants. Descriptive statistics were calculated for the variables, and the normality assumption was examined using the Kolmogorov-Smirnov and Shapiro-Wilk tests. The relationships between the variables were evaluated using Pearson’s product-moment correlation analysis. Mediation analyses were performed using the PROCESS Macro (Model 4) developed by Hayes, and the significance of indirect effects was tested using the bootstrap method (5000 samples). The internal consistency reliability of the scales used in this study sample was assessed using Cronbach’s alpha coefficient.ResultsThere are positive and significant relationships between each of the perceived social support sub-dimensions of appreciation, informational, emotional, and companionship and self-efficacy (r = 0.28–0.36; p <0.05). A positive and significant relationship was also found between the total perceived social support score and self-efficacy (r = 0.37, p <0.01). In contrast, no direct significant relationships were found between perceived social support and its sub-dimensions and psychological well-being (p> 0.05). Psychological well-being showed only a moderate, positive and significant relationship with self-efficacy (r = 0.45, p <0.01).ConclusionsIn conclusion, it can be said that the relationship between perceived social support and psychological well-being is not direct, but indirect, mediated by self-efficacy.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1847372</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1847372</link>
        <title><![CDATA[Neural correlates of altered loss aversion in alcohol use disorder: preliminary evidence of sex-related differences from 18F-FDG-PET imaging]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Brief Research Report</category>
        <author>Maria Arioli</author><author>Irene Bossert</author><author>Daniela D’Ambrosio</author><author>Elena Maria Andreolli</author><author>Giuseppe Trifirò</author><author>Nicola Canessa</author>
        <description><![CDATA[Previous findings suggest that the altered punishment sensitivity displayed by individuals with Alcohol Use Disorder (AUD) might reflect lower levels of loss aversion (LA), i.e., the tendency to overweigh negative relative to positive choice consequences. However, whether lower LA represents a core facet of abnormal decision-making in AUD, rather than a secondary consequence of defective executive functioning, remains debated. We used a gambling task to compare LA across 22 AUD patients and 19 age-, sex-, and education-matched healthy controls, and 18F-FDG-PET to investigate its neural correlates in the AUD sample, using 42 age/sex-matched PET healthy controls as the reference group for analyses on brain metabolism. Although AUD patients displayed both significantly lower LA and a hypometabolic pattern in the anterior cingulate and anterior insular nodes of the salience network, the behavioral finding was not explained by altered attentional or executive skills. Instead, we observed a negative relationship with left anterior insular metabolism and LA, possibly reflecting altered regulation of emotions associated with interoceptive processing. Within the AUD sample, lower LA was associated with a steeper negative relationship with frontomedial metabolism in males than in females, suggesting sex-related modulation of its neural correlates. While providing novel insights into the hypometabolic brain pattern associated with lower LA in AUD, these findings unveil sex-specific effects calling for tailored intervention approaches both in research and clinical practice.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1759800</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1759800</link>
        <title><![CDATA[An idiographic network approach to modeling daily loneliness and paranoia in psychosis: implications for personalized interventions]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Brief Research Report</category>
        <author>Jakub Januška</author><author>Daniel Dančík</author><author>Michal Hajdúk</author>
        <description><![CDATA[The call for personalized approaches in psychopathology is growing, as group-level analyses fail to capture the person-specific patterns. This study used an idiographic network approach to model the daily dynamics of loneliness, paranoia, affect, and social motivation in seven individuals with psychosis. We applied Group Iterative Multiple Model Estimation (GIMME) to intensive longitudinal data collected using the Experience sampling method. Results revealed substantial inter-individual heterogeneity, particularly in social motivation pathways and the role of paranoia in affective changes. Specifically, the relationship between social avoidance and approach was positive for one participant and negative for another. Furthermore, a unique temporal effect of paranoia predicting subsequent negative affect was identified in one case. These findings highlight the critical relevance of idiographic methods for moving beyond generalized models and identifying precise, actionable targets for developing tailored interventions in psychosis.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1798998</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1798998</link>
        <title><![CDATA[Homocysteine and cognitive function in depression: a systematic review and meta-analysis]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Systematic Review</category>
        <author>Xiaotong Liu</author><author>Qingsong Liu</author><author>Jili Xu</author><author>Jie Wu</author>
        <description><![CDATA[ObjectiveThis study aimed to assess the association between homocysteine (Hcy) levels and cognitive function in individuals with depression using a systematic review and meta-analysis.MethodsWe searched PubMed, Web of Science, EMBASE, the Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data, and the Chinese Science and Technology Journal Database (VIP) for studies reporting Hcy levels and cognitive outcomes in patients with depression from inception to December 2025. Methodological quality was assessed using the Agency for Healthcare Research and Quality (AHRQ) checklist, evidence certainty was evaluated using the GRADE approach, and meta-analyzes were performed using random-effects models in Stata 17.0.ResultsA total of 13 studies involving 1,269 patients with depression were included. The meta-analysis showed a significant inverse association between Hcy levels and cognitive scores (r = −0.41, 95% CI: −0.57 to −0.22, p < 0.001). High Hcy levels were associated with poorer cognitive performance (SMD = −0.37, 95% CI: −0.62 to −0.13, p = 0.003). Patients with cognitive impairment (CogI) also had higher Hcy levels than cognitively normal (CogN) individuals (SMD = 2.44, 95% CI: 0.86 to 4.01, p = 0.003).ConclusionsHcy levels are associated with CogI in patients with depression, and subgroup analyzes and leave-one-out sensitivity analyzes indicate that the direction of the association is generally consistent. Further prospective studies are needed to clarify the clinical relevance of Hcy and whether it may contribute to the assessment of cognitive impairment in depression.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD420251206956.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1806567</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1806567</link>
        <title><![CDATA[Recurrent blood-spitting as a somatic presentation of pediatric functional neurological disorder: a case report]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>Tu DH</author><author>Huong NM</author><author>Anh LN</author><author>Vinh NA</author>
        <description><![CDATA[BackgroundHemoptysis in children is typically associated with identifiable organic causes such as respiratory infection, bronchiectasis, or coagulopathy, and is often accompanied by respiratory symptoms or anemia. However, approximately 10–25% of pediatric cases remain cryptogenic or represent pseudohemoptysis despite extensive diagnostic evaluation.Case presentationWe report a 10-year-old boy presenting with daily recurrent blood-spitting manifested as scant blood-tinged saliva (<5 mL per episode) for 12 months. There were no accompanying respiratory or gastrointestinal symptoms, and no evidence of anemia. A comprehensive multidisciplinary evaluation including otolaryngology, pulmonology, gastroenterology (endoscopy), bronchoscopy, chest computed tomography, and video-electroencephalography revealed no organic source of bleeding. The episodes consistently co-occurred with psychogenic nonepileptic seizures during periods of psychosocial stress, including parental conflict and school-related anxiety.Diagnosis and outcomeThe patient was diagnosed with functional neurological disorder (FND) according to the DSM-5-TR criteria. Recurrent blood-spitting was interpreted as a somatic symptom occurring within the clinical context of FND. A multidisciplinary treatment approach—including cognitive behavioral therapy, family therapy, pharmacological management, and caregiver psychoeducation—was associated with rapid clinical improvement. At 6-month follow-up, only rare stress-related recurrences were reported. Salivary cytology demonstrated scant erythrocytes without evidence of active bleeding.ConclusionThis case highlights a possible clinical association between recurrent blood-spitting and functional neurological disorder in this clinical context. Early recognition of a functional etiology is essential to avoid unnecessary invasive investigations and to facilitate timely psychiatric intervention, leading to favorable clinical outcomes. Given the single-case design, causality cannot be established.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1782281</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1782281</link>
        <title><![CDATA[Assessing directional connections between symptoms, cognition, insight, and real-life functioning in schizophrenia: a partial ancestor graphs analysis]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Claudio Brasso</author><author>Gianluca Colli</author><author>Silvio Bellino</author><author>Paola Bozzatello</author><author>Cristiana Montemagni</author><author>Paola Rocca</author>
        <description><![CDATA[IntroductionSchizophrenia is a severe chronic mental disorder causing significant global disability. Understanding the intricate relationships between symptoms, cognitive functions, and real-life outcomes is essential for developing effective interventions. Prior research, while informative, could not often determine the direction of the association between these illness-related factors. This study aimed to investigate the possible causal connections within the interrelationships of these variables. MethodsThis cross-sectional study included 215 clinically stable patients diagnosed with schizophrenia. Comprehensive assessments covered psychopathology, neurocognition, social cognition, metacognition, clinical insight, and real-life functioning. Causal relationships were explored using Partial Ancestral Graphs, a causal discovery framework that accounts for mediators and confounders. The Greedy Fast Causal Inference algorithm was employed with 1,000 bootstrap replications to assign edge orientations.ResultsA central neurocognitive–metacognitive–functional system of directed connection emerged: visual learning was linked to attention/vigilance and working memory. Working memory showed a direct relationship with metacognition, which, in turn, was connected to real-life functioning. Two partly independent contributions to real-life functioning were also identified: conceptual disorganization and experiential negative symptoms, which were directly related to expressive deficits. Positive symptoms, depressive symptoms, and social cognition occupied peripheral positions, showing no significant connection with other variables. Unawareness and misattribution of symptoms showed an indeterminate association disconnected from the main network.DiscussionThe findings show a set of directed associations that start with neurocognitive abilities, pass through working memory and metacognition, and terminate in real-life functioning. Independently, conceptual disorganization and expressive negative symptoms also exert direct influences. These directed systems of connections provide operational guidance for clinical practice, highlighting critical targets for interventions such as cognitive remediation focused on working memory, metacognitive therapies, and strategies addressing disorganization and avolition, all aimed at improving real-life outcomes in schizophrenia.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1777387</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1777387</link>
        <title><![CDATA[Inaugural year of regulated psilocybin services in Oregon: safety, motivations, and utilization]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Brief Research Report</category>
        <author>Feliciano Yu</author><author>Joe Tafur</author><author>Francisco Moreno</author><author>Stephen Dahmer</author>
        <description><![CDATA[ImportanceThe Oregon Psilocybin Services (OPS) program is the first statewide, regulated framework for legal psilocybin in the U.S. Analyzing inaugural-year utilization and safety is essential for informing policy and equity monitoring.MethodsWe conducted a descriptive analysis of statewide aggregate data from the OPS Public Dashboard (January 1–December 31, 2025). Outcomes included service volume, client demographics, motivations, and acute adverse events.ResultsIn 2025, 5,935 clients participated in 5,375 sessions. Volume peaked in Q2 (n=1,758) before stabilizing in Q4 (n=1,358). Service tourism was significant, with 32.6% of participants residing outside Oregon. The largest segment was aged 35–49 (~40%); women (57.4%) and LGBQ+ individuals (27.2%) represented substantial portions of the annual cohort. Racial diversity was limited, with White participants representing 84.1%–91.5% quarterly, while Hispanic/Latino (7.1%) and African American (2.1%) participation lagged. Adverse events were rare, with annual behavioral and medical rates of 2.42 and 2.79 per 1,000 sessions, respectively.DiscussionFull-year data indicate stabilized utilization by a predominantly midlife adult population. While the program successfully reaches sexual and gender minorities, racial disparities persist. High service tourism suggests significant socioeconomic barriers. These findings underscore the program’s dual role as a wellness modality and a functional alternative for addressing mental health distress.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1764597</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1764597</link>
        <title><![CDATA[From cats to cortex: T. gondii and psychosis, depression, and anxiety]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Mini Review</category>
        <author>Gabriel Andrade</author><author>Abderrahim Benlahcene</author><author>Dalia Bedewy</author>
        <description><![CDATA[This review examines whether cat ownership, via exposure to the neurotropic parasite T. gondii, contributes to vulnerability for psychotic, depressive, and anxiety symptoms. T. gondii establishes lifelong latent infection in the brain and muscle, where it can modulate dopaminergic signaling, neuroinflammation, and tryptophan–kynurenine metabolism, providing a biologically plausible pathway to altered cognition, mood, and behavior. Epidemiological and meta-analytic data indicate small-to-moderate associations between T. gondii seropositivity and schizophrenia, with more variable but suggestive links to depression and anxiety. Evidence for cat ownership as an independent risk factor is inconsistent: some cohorts and recent meta-analyses report elevated odds of schizophrenia-related outcomes in those exposed to cats, whereas rigorously controlled studies frequently find attenuated or null effects. Methodological limitations, alternative explanations, and cultural implications are discussed, and priorities for mechanism-informed, longitudinal and interventional research are outlined.]]></description>
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