AUTHOR=Atzori Barbara , Hoffman Hunter G. , Vagnoli Laura , Patterson David R. , Alhalabi Wadee , Messeri Andrea , Lauro Grotto Rosapia TITLE=Virtual Reality Analgesia During Venipuncture in Pediatric Patients With Onco-Hematological Diseases JOURNAL=Frontiers in Psychology VOLUME=Volume 9 - 2018 YEAR=2018 URL=https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2018.02508 DOI=10.3389/fpsyg.2018.02508 ISSN=1664-1078 ABSTRACT=Abstract Background. Venipuncture is described by children as one of the most painful and frightening medical procedures. Objective. To evaluate the effectiveness of Virtual Reality (VR) as a distraction technique to control pain in children and adolescents undergoing venipuncture. Methods. Using a within-subjects design, fifteen patients (mean age 10.92, SD = 2.64) suffering from oncological or hematological diseases received one venipuncture with “No VR” and one venipuncture with “Yes VR” in two separate days (treatment order randomized). “Worst pain”, “Pain unpleasantness”, “Time spent thinking about pain”, the quality of VR experience, fun and nausea were measured. Results. During VR, patients reported significant reductions in “Time spent thinking about pain”, “Pain unpleasantness” and “Worst pain”. Patients also reported significantly more of fun during and reported a “Strong sense of going inside the computer-generated world” during VR. No side effects were reported Conclusions. VR can be considered an effective distraction technique for children and adolescents’ pain management during venipuncture. Moreover, VR may elicit positive emotions, more than traditional distraction techniques. This could help patients cope with venipuncture in a non-stressful manner. Additional research and development is needed.