AUTHOR=Dong Daifeng , Jiang Yali , Gao Yidian , Ming Qingsen , Wang Xiang , Yao Shuqiao 

TITLE=Atypical Frontotemporal Connectivity of Cognitive Empathy in Male Adolescents With Conduct Disorder

JOURNAL=Frontiers in Psychology

VOLUME=9

YEAR=2019

URL=https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2018.02778

DOI=10.3389/fpsyg.2018.02778

ISSN=1664-1078

ABSTRACT=<p><bold>Background:</bold> It has been suggested that adolescents with conduct disorder (CD) may have a deficit in the affective and cognitive domains empathy, but studies exploring networks within the key brain regions of affective and cognitive empathy in adolescents with CD are lacking.</p><p><bold>Methods:</bold> Functional connectivity (FC) analyses among key brain regions of the affective and cognitive empathy with resting-state functional magnetic resonance imaging (fMRI) were conducted in 30 adolescent boys with CD and 33 demographically matched healthy controls (HCs).</p><p><bold>Results:</bold> Atypical FC within the key brain regions of affective empathy was not observed in CD adolescents. However, we found that CD adolescents showed decreased frontotemporal connectivity within the key brain regions of cognitive empathy in relation to HCs, that is, the FCs between right temporoparietal junction and ventromedial prefrontal cortex as well as dorsomedial prefrontal cortex.</p><p><bold>Conclusion:</bold> These findings may provide insight into neural mechanism underlying a cognitive empathy deficiency of CD adolescents from the perspective of FC.</p>