AUTHOR=Bergmann Niklas , Hahn Eric , Hahne Inge , Zierhut Marco , Ta Thi Minh Tam , Bajbouj Malek , Pijnenborg Geradina Henrika Maria , Böge Kerem TITLE=The Relationship Between Mindfulness, Depression, Anxiety, and Quality of Life in Individuals With Schizophrenia Spectrum Disorders JOURNAL=Frontiers in Psychology VOLUME=Volume 12 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2021.708808 DOI=10.3389/fpsyg.2021.708808 ISSN=1664-1078 ABSTRACT=Schizophrenia spectrum disorders are frequently accompanied by comorbid depressive and anxiety symptoms, as well as impaired quality of life. A growing body of evidence has demonstrated the relevance of mindfulness for schizophrenia spectrum disorders in recent years. The study examined the association between mindfulness, depression, anxiety, and quality of life. A total of 83 participants with schizophrenia spectrum disorders (SSD) were recruited at the in- and outpatient psychiatric hospital care. Participants completed the Southampton Mindfulness Questionnaire, Comprehensive Inventory for Mindful Experiences, and Freiburger Mindfulness Inventory, the Depression, Anxiety, Stress Scale to assess depression and anxiety, and the WHO-Quality of Life Questionnaire. Multiple regression analyses examined the relationship between mindfulness and quality of life and the mediating role of depression and anxiety. Mindfulness had a significant statistical positive effect on quality of life domains physical health, psychological and environmental quality of life in patients with SSD. Depression was identified as a significant mediator of this relationship. This study provides novel insight into mindfulness' mechanisms and paves the way for a process-oriented approach to treat schizophrenia spectrum disorders. The results provide first evidence for the process-based value of mindfulness for schizophrenia spectrum disorders; future studies can focus on the role of mindfulness for central therapeutic processes of change by employing longitudinal designs.