AUTHOR=Li Jiawei , Ma Hui , Yang Hao , Yu Haoran , Zhang Ning TITLE=Cognitive bias modification for adult’s depression: A systematic review and meta-analysis JOURNAL=Frontiers in Psychology VOLUME=Volume 13 - 2022 YEAR=2023 URL=https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2022.968638 DOI=10.3389/fpsyg.2022.968638 ISSN=1664-1078 ABSTRACT=Abstract Objects This study aimed to elucidate the effect of cognitive bias modification on depression. Methods This research included 10 randomized studies searching four major databases: PubMed, EMBASE, PsycINFO and Cochrane Library, with a total sample size of 467. Moreover, they were examined for quality and possible publication bias. Results CBM had a statistical significance results g = -0.64, 95% CI = [-0.97 -0.32]. the interpretation of cognitive bias modification shows highest effect size g = -1.45, 95% CI = [-2.05 -0.88]. When the training place is located in the laboratory, the training effect is significant g = -1.11, 95% CI = [-1.62 -0.61]. the difference is statistically significant when the training environment was changed to home g = -0.28, 95% CI = [-0.51 -0.05]. CBM has a statistical effect on moderate to severe depression g = -0.70, 95% CI = [-1.04 -0.36]. Conclusion We found that CBM had a moderate therapeutic effect on depression, wherever the setting was at home or in the lab. Especially when the interpretation of cognitive bias modification (CBM-I) has been used, we got the highest effect value. Furthermore, CBM has a statistical effect on moderate to severe depression. Keywords cognitive bias modification, depression, review, meta-analysis