AUTHOR=Huang Gengdi , Han Chuanliang , Yang Jihui , Ye Caihong , Javed Iqbal , Liu Fen , Kong Zhi , Li Ying , Zhu Yingmei , Yi Guangyong , Ju Chuanjia , Jia Xiaojian , Yang Mei 

TITLE=Neural basis of the attention bias during addiction stroop task in methamphetamine-dependent patients with and without a history of psychosis: an ERP study

JOURNAL=Frontiers in Psychology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2023.1173711

DOI=10.3389/fpsyg.2023.1173711

ISSN=1664-1078

ABSTRACT=Abstract
Background: The attentional bias plays an important role in sustaining various types of drug addiction. No prior studies examined methamphetamine associated psychosis (MAP) relationships between ERP time course and performance on an Addiction Stroop task in MA abusers. The aim of the present study was to determine whether MA abusers with (MAP+) or without (MAP-) psychosis exhibit alterations of the ERP during Addiction Stroop task. Methods: 31 healthy controls (CTRL), 13 MAP-, and 24 MAP+ participants were recruited and completed the Addiction Stroop task during EEG recording with 32 electrodes. Group variations were compared on measures of behavioral task performance, and event-related potentials (ERP) of performance monitoring (N200, P300, N450). Barratt impulsiveness scores were analyzed to investigate correlations with ERP changes. Results: MA words stimulus elicited a more negative N200 amplitude over left-anterior electrodes in MAP- abusers, furthermore, a positive association between N200 amplitude and Barratt attentional scores and nonplanning scores were observed, while no such differences were found in MAP+ abusers. There were no significant differences in reaction time (RT) and error rate between each group. Conclusion: This study is the initial study to examine psychosis relationships between ERP time course and performance on an Addiction Stroop task in MA abusers with or without MAP. These findings support the association between attentional bias measured by the MA Addiction Stroop Task and N200 component, and also indicate the possibility of using this cognitive task in combination with ERP technology to detect psychosis factor among abstinent MA abusers.