The effect of conscious mindfulness-based informative approaches on managing symptoms in hemodialysis patients

Introduction The research was conducted to determine the effect of conscious mindfulness based informative approaches applied in hemodialysis patients on reducing stress and managing symptoms. Methods This research was conducted as a real experimental model with a control group. Research population consisted of 160 hemodialysis patients. The sample of the study was determined as 120 hemodialysis patients in total, 60 in the experimental and 60 in the control group, as a result of the power analysis. After the pre-test application, a mindfulness-based stress reduction program was applied to the experimental group. In the analysis of the data collected in the research, percentage, frequency, chi-square analysis, t-test for independent groups, t-test for dependent groups were used by means of SPSS for Windows 22.00 statistical software package. Results The t-test analyses of the differences between pre-test and post-test scores of hemodialysis patients in the experimental group were found to be significant in favor of the post-tests. Discussion It was found out that the conscious mindfulness-based informative approaches decreased the perceived stress and anxiety of the patients in the experimental group, whereas increased their levels of conscious mindfulness and symptom management.


Introduction
Administration of hemodialysis (HD) treatment has helped the lengthening of the patients' lifetime, as a result of which development all attention has been directed to the problems experienced by hemodialysis patients (Sanlıtürk et al., 2018).It is observed that HD patients have been suffering itching and rashes, skin dryness, fatigue, nausea, vomiting, constipation, diarrhea, sleep disorders, pain, muscle cramps, sexual problems, body image disturbance, impaired social functioning, problems in family/business/school life, economic difficulties, burnout, stress, depression, and anxiety (Almutary, 2022).Rate, frequency and intensity of symptoms vary from one patient to another, however, as the intensity and frequency of the symptoms get higher, many of the patients exhibit despair, ambiguity, burnout and depression, resulting in impaired quality of life (Tolasa and Akyol, 2017).
According to Almutary's (2022) study, patients undergoing hemodialysis develop high levels of depression and daytime somnolence, which symptoms appear to be the main determinant of life quality.Another study undertaken suggests that patients undergoing hemodialysis have been frequently suffering anxiety and depression, which symptoms exert adverse impacts on the patients' quality of life.According to the same research, positive effects are achieved when symptoms of anxiety and depression are determined and treated at an early stage (Al-Nashri and Almutary, 2022).
According to Eren's (2019) research, most encountered symptoms in hemodialysis patients are fatigue or lethargy, reduced sexual interest, reduced sexual satisfaction, and nervous temperament, whereas least frequent ones are muscle pain, difficulty in keeping the legs still, and diarrhea.In the study by Akgöz and Arslan (2017), it has been identified that most frequent symptoms in HD patients were fatigue, reduced physical energy, headache, bone pain and arthralgia.
In conclusion in the case of HD patients, developing terminal behaviors in lifestyle, achieving adherence to therapy, and controlling symptoms are of major importance.Health professionals who have sufficient training and knowledge on HD treatment should assume significant roles such as informing the patients about the treatment they have been receiving and providing them with necessary knowledge and skills (Al-Nashri and Almutary, 2022).However, according to many researches, it has been observed that individual awareness of hemodialysis patients is quite low despite all suggestions made and guides drawn up in that regard (Tuot et al., 2015).
Conscious mindfulness (CM) is a concept that is related to focusing on the present moment, which involves observations and acceptance without judgment on inner and outer experiences (Mantzios and Giannou, 2018).CM suggests that people may, by staying in the present moment, cope with emotional distress which comes along with their thoughts (Igarashi et al., 2021).When the level of awareness in respect of what is being experienced in the present moment is low, automatic behaviors not controlled by the conscious are displayed.As CM level of the individuals gets higher, they develop stronger coping strategies in adverse conditions (Tırıskan et al., 2015).CM-based approaches may be used in helping the individual patients to become aware of their potential power, establish body-mind connection, and in accelerating the healing process.Furthermore, CM-based approaches serve as an effective tool in regard to strengthening the communication between the health professional and the patient, and also in terms of creating a suitable therapeutic environment (Körükcü and Kukulu, 2015).
Various methods are being applied to raise the level of awareness.One of these methods is the mindfulness-based stress reduction program (MBSRP).Kabat-Zinn (2003) has conducted the earliest studies on this subject at the Mindfulness Center of the Massachusetts Institute of Technology and founded the mindfulness-based stress reduction program (MBSRP).MBSRP was initially formed to reduce the pains of patients but later used to cope with problems such as stress as well.MBSRP is a group program that proceeds step by step, which is applicable as an individual method or as a complementary, supportive one (Catak and Ogel, 2010;Gherardi-Donato et al., 2023).
MBSRP is being applied in treatment of symptoms associated with cancer, treatment of obesity, treatment of sleep disorders, functional healing of schizophrenic patients, symptomatic treatment of Parkinson patients, and reduction of anxiety in transplant recipients, along with increasing the level of motivation and conscious mindfulness in non-patient groups (Harvard Business School Publishing and Corporation, 2017).MBSRP helps people to develop acceptance and alternative reactions instead of negative thought (Ji et al., 2023).CM training is related to changes affecting biological processes, such as heartbeat, breathing and immune functions, in brain regions that are responsible for stress reactions and emotional regulation (Boyd et al., 2018).
Studies undertaken have shown that, in the case of HD patients displaying symptoms of anxiety and depression, MBSRP is an applicable and tolerable program that might yield positive results (Thomas et al., 2017).
It has been scientifically proven that MBSRP enhances the quality of life and self-sufficiency/efficacy levels of HD patients (Solati et al., 2019), reduces anxiety and depression (Haghshenas et al., 2019), and improves general mental health and biochemical marker levels of individuals (Sohn et al., 2018).Moreover, MBSRP reduces physical symptoms, anxiety, sleep disorders, social malfunctions, depression symptoms (Nejad et al., 2018), and improves self-compassion and serum phosphorus levels (Igarashi et al., 2021).
In conclusion this research has been conducted with a view to determining the effect of conscious mindfulness-based informative approaches applied in hemodialysis patients on reducing stress and managing symptoms.
To achieve the purpose of the research, the following hypotheses were tested.
Hypothesis 1: Mindfulness-based informative approaches reduce stress levels in hemodialysis patients.
Hypothesis 2: Mindfulness-based informative approaches provide symptom management in hemodialysis patients.
10.3389/fpsyg.2024.1363769effect size, and 0.98 representation power.Randomization method was employed in the selection and grouping of samples.The sample was created by taking into account the inclusion and exclusion criteria for the study.The sample was made up of individuals over the age of 18 who were open to communication and agreed to participate in the study (Mertens, 2019).Throughout the research process no patients have left the experimental or control group wherefore the research was completed with the participation of 120 patients who agreed to take part in the study.In order to prevent patients from being affected by each other during the research process, drawing of lots between two dialysis centers has taken place as a result of which the patients hospitalized at Atatürk University Research Hospital Hemodialysis Unit were determined as the experimental group.

Measure
In the gathering of data, personal information sheets, mindful attention awareness scale, dialysis symptom index, perceived stress scale, and Beck anxiety scale were used.

Personal data collection form
This personal information sheet is a questionnaire prepared by the researchers, which includes socio-demographic details (age of patient, level of education, spouse's level of education, employment status, spouse's employment status, economic condition) and HDrelated data.

Mindful attention awareness scale
Mindful attention awareness scale (MAAS) was developed by Brown and Ryan (2003).Adaptation efforts respecting its validity and reliability in the Turkish domain were undertaken by Ozyeşil et al. (2011).MAAS which consists of 15 items is a scale that measures the overall tendency with regard to receptive awareness of and attention to momentary experiences in daily life.MAAS has a one-factor structure and gives a single total score.High scores obtained from the scale indicate high levels of mindfulness.MAAS is a 6-level (almost always, usually, sometimes, quite seldom, rarely, almost never) Likert type scale.Cronbach Alpha coefficient of the scale is 0.82.In this study, subject coefficient was found as 0.90.

Dialysis symptom index
Dialysis symptom index (DSI) was developed by Weisbord et al. (2004) with a view to measuring the level of distress experienced by hemodialysis patients in respect of symptoms.Adaptation efforts respecting its validity and reliability in the Turkish domain were undertaken by Onsöz and Yesilbalkan (2013).Answers regarding symptoms experienced in the last seven days are given as "yes" or "no."When the answer is "yes, " a 5-level Likert scale, i.e., 1 = none, 2 = a little, 3 = sometimes, 4 = very little, 5 = too much, is applied to determine to what degree the patient's life is affected by the symptom in question.Points obtained are added to find the total scale score.Total score from the index may vary between 0 and 150.No symptoms are present if the score is 0.Where the total score has approached 150, such situation indicates that the effect of subject symptom has increased.Cronbach Alpha coefficient of the scale is 0.89.On the other hand, cited coefficient was found as 0.87 in this research.

Perceived stress scale
Perceived stress scale (PSS) was developed by Cohen, Kamarck and Mermelstein.Adaptation efforts respecting its validity and reliability in the Turkish domain were undertaken by Eskin et al., 2013.PSS is a 14-item scale that has been designed to measure how stressful certain situations in the individual's life are perceived.Participants evaluate every item on a 5level Likert type scale which ranges between "Never (0)" and "Very frequently (4)." 7 of the items which involve positive statements are given points in the reverse order.PSS forms have 14, 10 and 4-item versions.Cronbach Alpha coefficient of the scale is 0.86.In this study, such coefficient was found as 0.80.

Beck anxiety scale
Beck anxiety scale (BAS) was developed by Beck et al. (1988) to evaluate the frequency of anxiety symptoms.Adaptation work respecting its validity and reliability in our country was undertaken by Ulusoy et al. (1998) BAS which consists of twenty-one items is a Likert type evaluation scale with a scoring range between 0 and 3.This scale has been designed to measure the frequency of anxiety symptoms experienced by the individual.The higher the total score, the higher the anxiety experienced by the person.Cronbach Alpha coefficient of the scale is 0.92.In this research, subject coefficient was found as 0.92 as well.

Procedure
Pre-test data was collected in one week by way of face-toface interviews with the patients in the experimental and control groups, which interviews were held every day excluding Sunday.Information gathered by use of data collection tools was read and answers given were marked by the researcher.Likewise, post-test data was also collected in one week again by way of face-toface interviews with the patients in the experimental and control groups, which interviews were held every day other than Sunday.Information gathered by means of data collection tools was read and answers given were marked by the researcher.Respective data was collected from the patients in the experimental and control groups two weeks after the completion of mindfulnessbased stress reduction program that has been applied to the experimental group.

Criteria respecting inclusion in the research study;
• Being open to communication, • Not suffering any diagnosed psychiatric disorder Criteria respecting exclusion from the research study; • Failure to participate in two applications minimum • Failure to participate in post-tests

Mindfulness-based stress reduction program
In this study, following the pre-test application, the experimental group was applied a mindfulness-based stress During the very first meeting with the patients in the experimental group, an acquaintance meeting was held which was followed by delivery of information on MBSR.In addition, a publication entitled "Mindfulness-Based Stress Reduction Program Training Booklet for Symptom Management in Hemodialysis Patients, " which was drawn up by the researcher by making use of the relevant literature, was distributed to the patients.Patients in the experimental group were divided into four subgroups on the basis of the day and time they would undergo HD, i.e., Monday-Wednesday-Friday morning and afternoon groups, and Tuesday-Thursday-Saturday morning and afternoon groups.The program was applied according to the following format: 2 days a week, 4 sessions a day, and one session a week for each group consisting of 10-15 patients.
In the course of the research process, no intervention was applied to the control group.Upon completion of the study, the "Mindfulness-Based Stress Reduction Program Training Booklet for Symptom Management in Hemodialysis Patients" was distributed to the patients in both groups (namely, experimental and control groups).The patients were recommended to properly and effectively do the exercises specified in the booklet concerned.
The researcher has participated in necessary certification programs to implement the MBSRP.Throughout the course of the program, patients in the experimental and control groups continued to undergo their pharmacological treatment, HD sessions, doctor checks, and routine applications of the HD center.
The contents of mindfulness-based stress reduction program are given in Table 1 below.You may be distracted, focus on your breathing again Try this for five minutes, then stop and evaluate how you feel.

Mindful listening exercise
Mindful silence is more than just not speaking, it is an active silence.You can devote a day to this.
During active silence, you can eat and do your daily work.
Watching TV, listening to the radio, making phone calls and reading written materials should not be in silence.
Meanwhile, direct your attention to activated thoughts and emotions and stay aware.
Look at how you do your work during the silence, slow or fast?Perceive what you felt and thought during the silence.

Mindful observation exercise
For this exercise, you need a leaf or another object and 10-15 min of time.
Look at the object with all your attention and try to explore it Touch the object, examine its color, shape, size and every detail.Look very closely and from a little distance.Smell it.
You may be distracted, try to bring your mind back.

Tonglen (giving and taking) exercise
Focus on your body when you see or think about a person you don't like, This doesn't even have to be a person, it can be a memory that bothers you or a worry about the future.
If you feel tension in your body, first notice it, Then allow it, don't try to find a solution right away After turning your face to this difficulty, take a breath in, inhale this difficulty, exhale and wish well.
These wishes may be wishes such as "I wish you to be at peace, I wish you to feel lighter, I wish you compassion, I wish you to be safe."

Mindful eating exercise
You can do this exercise with anything you eat or drink.To practice the exercise, choose a certain meal (e.g., breakfast, lunch) or a certain food (e.g., bread, chocolate).
Let's exemplify this exercise with tea.Drink only tea, limit activities such as watching television, talking, reading.
Look at the color of the tea, smell it and perceive what its smell is.
Be thankful.
Think about where the tea grows and what stages it goes through until it reaches the cup.
Think about who provided it for you, who prepared it for you, and be grateful.
Close your eyes and sip your tea Repeat these with every sip, wonder each time, try to understand again.Don't forget to smile

Statistical analysis of research data
In the analysis of data gathered during the research, percentage, frequency, chi-square analysis, t-test for independent groups, t-test for dependent groups were used by means of SPSS for Windows 22.00 statistical software package.

Comparison of hemodialysis patients in the experimental and control groups in terms of their defining characteristics
When defining characteristics of control and experimental groups as given in Table 2 are examined, a comparison made in respect of the patients' ages, genders, educational background, employment status, level of income, presence of chronic diseases other than chronic renal failure (CRF), years of dialysis, and missed HD sessions, indicates that the experimental and control groups are quite alike (p > 0.05).

Comparison of pre-tests and post-tests of the experimental group before and after the trainings
When Table 4 is examined, it is observed that the t-test analyses of the differences between PSS, BAS, MAAS and DSI pre-test and post-test scores of HD patients in the experimental group before and after the trainings provided were found to be significant in favor of the post-tests (p < 0.001, p < 0.01).

Comparison of pre-and post-tests of hemodialysis patients in the control group before and after the trainings
When Table 5 is examined, it was found that the differences between the BAS pre-test and post-test scores of HD patients in the control group before and after the study were significant against the post-tests, while the differences between the PSS, MAAS, DSI pre-test and post-test scores were statistically insignificant.
According to research data, it may be suggested that MBSRP was effective on PSS, BAS, MAAS and DSI scores, i.e., the MBSRP applied has reduced stress and anxiety levels of hemodialysis patients and raised their conscious mindfulness and symptom management levels.

Discussion
The findings and results of the research that was conducted with a view to determining the effect of conscious mindfulness based informative approaches applied in the case of HD patients on reducing stress and managing symptoms have been discussed in line with the relevant literature.As a result of the literature research and review, it has been observed that the process involving application of mindfulness-based stress reduction program to HD patients was quite new wherefore only a limited number of studies could be accessed.For this reason, research results were discussed in reference to the findings of the most recent study as well.
According to the results of our study it is observed that the highest complaints of the patients in the experimental group involved the following symptoms: fatigue or lethargy, nervous temperament, feeling sad, distress, sleep-maintenance insomnia, sleep-onset insomnia, numb or tingling feet, and muscle cramps.On the other hand, the lowest complaints of the patients in the experimental group included the following symptoms: poor concentration, dry mouth, coughing, chest pain, difficulty in keeping the legs still, vomiting, and diarrhea.In the case of control group, patients complained about the following symptoms for the most part: fatigue or lethargy, distress, feeling sad, nervous temperament, sleeponset insomnia, sleep-maintenance insomnia, headache, and numb or tingling feet.On the other hand, the lowest complaints of the patients in the control group involved the following symptoms: chest pain, dry mouth, coughing, muscle pain, swollen legs, difficulty in keeping the legs still, and poor concentration.In the study by Hintistan and Deniz (2018) that was conducted with respect to Symptom Evaluation in Patients Undergoing HD Treatment, most frequent symptoms experienced by HD patients were identified as fatigue/lethargy, bone pain/arthralgia, and muscle cramps.According to a research by Taylan and Özkan (2020), symptom clusters were grouped as follows: feeling sad, nervous temperament, distress, feeling anxious, and other similar psychological symptoms as the first group; sleep-onset insomnia, sleep-maintenance insomnia, feeling uncomfortable, and shortness of breath symptoms as the second group; and reduced sexual interest and reduced sexual satisfaction symptoms as the third group.On the other hand, in a study by Thong et al. (2009), symptom clusters were divided into the following groups: shortness of breath, drowsiness, and poor appetite as the first When the literature is examined, it is observed that, in terms of symptoms -which the HD patients complained about-with the highest and lowest frequencies, findings in the literature are similar to those of our research in some cases but also differ from our findings in some other cases.It is considered that such difference stems from adherence/nonadherence to treatment and diet program, presence of other chronic diseases, and medications administered.
In our study, it was found that MBSRP reduced the level of stress and anxiety experienced by hemodialysis patients and enhanced their levels of conscious mindfulness and symptom management.
Additionally, in our study, it was observed that there was a negative change in the PSS, BAS, MAAS and DSI scores of HD patients in the control group.
In On the other hand, in a study by Sohn et al. (2018) that was undertaken for the purpose of identifying the effectiveness of mindfulness and group cognitive behavioral therapy in HD patients experiencing end-stage renal failure, it was determined that Cognitive Behavioral Therapies involving mindfulness-based cognitive therapy program (MBCTP) and mindfulness-based stress reduction program (MBSRP) have improved general mental health and biochemical marker levels of individuals with end-stage renal failure who have been undergoing hemodialysis.In their research which was conducted with a view to evaluating the impact of mindfulness program on the general health of patients undergoing hemodialysis, Nejad et al. (2018) have expressed that mindfulness was effective in reducing physical symptoms and anxiety, sleep disorders, social malfunctions, and depression symptoms.
According to the study conducted by Razzera et al. (2022), to investigate the effect of mindfulness-based programs on chronic renal failure patients receiving hemodialysis treatment; mindfulness-based programs can offer a promising and safe complementary therapy for people with CRF undergoing hemodialysis, acting on quality of life and physical aspects of the disease.According to the study conducted by Nassim et al. (2021), in patients undergoing dialysis, mindfulness-based programs may be helpful intervention for depression symptom.Alhawatmeh et al. (2022) in his studies (2022); found that mindfulness meditation is effective in managing stress and improving quality of life in patients undergoing hemodialysis.
According to Carver and Cheung (2021); yoga breathing/mindfulness meditation on symptoms and COVID-19-related anxiety in patients receiving dialysis is feasible and acceptable.According to Rigas et al. (2022); mindfulness-based interventions is effective in treating depression and anxiety and improving mood disorder symptoms in patients receiving hemodialysis.
In their study, Al-Ghabeesh et al. (2021) found that mindfulness could improve the psychological health of hemodialysis patients.According to Garel et al. (2023); mindfulness-based stress reduction (MBSR) intervention is effective in managing pain and psychiatric symptoms in hemodialysis patients.According to Hernandez et al. (2021); Awareness-Based Program in Hemodialysis Patients reduces symptom severity without negative effects.According to the study of Dehghan et al. (2021); Awareness is effective in reducing coronavirus anxiety in hemodialysis patients.
When results derived from studies applied in the case of HD patients are examined, it is observed that such findings are similar to those of our research.
In their relevant study, Shapiro et al. (2005) have reported that, as a result of mindfulness-based stress reduction program for healthcare professionals, the individuals who took part in the program stated considerable reduction in perceived stress, increase in self-compassion, more content with life, lower job burnout, and diminished distress.In the research undertaken by Xunlin et al. (2020) with a view to determining the effectiveness of mindfulness-based interventions in the case of cancer patients, it was identified that mindfulness-based interventions might be used as an adjuvant therapy in the treatment of symptoms associated with cancer.On the other hand, Medina et al. (2017) have specified in their study on the effect of mindfulness on DM that mindful awareness may exert positive influences on any and all aspects of diabetes.
In a study by Ozdemir and Kavak Budak (2022) it has been determined that considerable enhancement was registered with respect to the level of hope, psychological wellbeing and functional healing, and that mindfulness-based stress reduction therapy was more effective than psychoeducation in raising the level of hope, psychological wellbeing and functional healing of schizophrenic patients.On the other hand, Sarıtas and Aktura (2020) have identified in their research that mindful awareness of the patients with cardiac insufficiency was at medium level, and that conscious mindfulness affected the level of anxiety and depression positively.
In her study, Sener and Timur Tashan (2021) has determined that mindfulness-based stress reduction program was effective in reducing menopausal complaints of women in the postmenopausal period and also in enhancing their quality of life in the subject period.According to a research by Heide et al. (2021) it was concluded that mindfulness had strong effects on anxiety and depressed mood of Parkinson patients, and that mindfulness might reduce the intensity of symptoms thereby improving the general condition of the patient.According to Kerr et al. (2013) study, mindfulness-based practices reduce stress in chronic pain and the risk of recurrence of depression.According to the same study, mindfulnessbased practices increase cognitive regulation and thus increase metacognition.Gherardi-Donato et al. (2023) in their study, they showed that the mindfulness-based program was effective on mental health psychometric measures (perceived stress and anxiety) and longterm stress biomarkers (hair cortisol).According to the study, the mindfulness program is also effective in improving the mental health of university employees.Finally, in a study by Gross et al. (2010) it was determined that MBSRP reduced anxiety, depression and bothersome symptoms of poor sleep in the case of transplant recipients, and hence enhanced their quality of life.According to Guu et al. (2023); mindfulness-based stress reduction program (MBSR) affects brain functionality.
As a result of the literature research and review, it was observed that conscious mindfulness-based informative approaches applied in groups suffering chronic diseases other than CRF and in nonpatient groups brought about positive changes.

Conclusion
In this research which was conducted so as to determine the effect of conscious mindfulness-based informative approaches applied in hemodialysis patients on reducing stress and managing symptoms, it was found out that the conscious mindfulness-based informative approaches decreased the perceived stress and anxiety of HD patients, whereas increased their levels of conscious mindfulness and symptom management.

Ethical aspect of the research
Necessary research ethics committee approval was obtained from İnönü University Scientific Research and Publication Ethics Board and Malatya Clinical Research Ethics Board.In addition, verbal and written permits were received from Atatürk University Research Hospital and Erzurum Regional Training and Research Hospital.With a view to implementing the MBSR program, the researcher has participated in necessary certification programs.Throughout the course of the program, patients in the experimental and control groups continued to undergo their pharmacological treatment, HD sessions, doctor checks, and routine applications of the HD center.

Limitations, future directions and implications
The strength of this study is that there are a limited number of studies examining the effect of MBSRP use on hemodialysis patients.In recent years, non-pharmacological complementary and integrative interventions have become increasingly used in the management of diseases.Among these initiatives, awareness-based interventions have begun to be increasingly implemented in families, the elderly, children, women, and various patient groups.
Applications such as MBSRP are a powerful tool in improving the relationship between healthcare professionals and patients, decision-making, diagnosis, therapeutic approach, and reducing stress in the patient and healthcare professionals themselves.Considering that the responsibilities of health professionals will increase over time, it is seen that individuals need to follow and be informed about both pharmacological and non-pharmacological applications for their problems.In order to be beneficial to themselves and individuals, healthcare professionals must know both the psychological and biological effects of MBSRP and complete the necessary certification and training programs to implement the program more effectively.
The limitation of this study is that the duration of monitoring individuals was limited to 8 weeks because the program was carried out within a certain period of time.Research results can be generalized to groups and the population that are similar in terms of inclusion criteria and study variables.In line with these results, it is recommended that conscious mindfulness-based informative approaches such as mindfulness-based cognitive therapy program and mindfulness-based stress reduction program be added to treatment and care programs of hemodialysis patients, and that new studies be undertaken to ensure the comparison of different complementary and supportive alternative medicine applications with mindfulness-based stress reduction program.
Feel the feeling, taste and aroma of the tea in your mouth Smell it, is it the same or different from what you first felt Swallow slowly, paying attention to what you hear as it passes down your throat.Pay attention to what you feel when swallowing Think about the amount of sips you take, perceive how fast you drink, slow or fast.
The program has lasted 8 weeks and each session 2 h.Application of the program was conducted in the HD room.Due to inconvenient conditions prevailing at the hospital, MBSRP did not include yoga or meditation applications.
Create a comfortable posture.Sit with your spine erect and straight Leave your eyes relaxed, they can be open or closed Your hands are relaxed, close to your body, palms facing up or down Breathe slowly, deeply Bring your attention to the inflow and outflow of your breath Follow the journey of your breath through your body, slowly watch how your nose, trachea and lungs react.

TABLE 1
The contents of mindfulness-based stress reduction program.Create a comfortable posture.Sit with your spine erect and straight Your eyes may be slightly closed Breathe slowly, deeply and follow your breath Bring your attention to your body.Perceive and accept what sensations you have in your body right now.Then focus your attention on the sounds around you.Detect low and loud sounds, detect whether sounds are close or far away.Just perceive the sounds, you don't need to give them meaning.You may be distracted, turn to the sounds again End the exercise and open your eyes slowly.

TABLE 2
Defining characteristics of HD patients in experimental and control groups.

TABLE 3
Distribution of the frequency and mean value of symptoms experienced by patients undergoing hemodialysis treatment.

TABLE 4
Comparison of pre-test and post-test scores of HD patients in the experimental group before and after the trainings.

TABLE 5
Comparison of pre-test and post-test scores of hemodialysis patients in the control group before and after the trainings.
their study aimed at determining the effectiveness of mindfulness-based stress reduction program in HD patients experiencing anxiety and depression, Haghshenas et al. (2019) have shown that MBSRP reduced the level of anxiety and depression suffered by such HD patients.In a research by Solati et al. (2019) which was conducted with respect to the effect of Mindfulness-Based Cognitive Therapy on the life quality and self-sufficiency/ efficacy of HD patients, it was determined that mindfulness-based cognitive therapy program has enhanced the quality of life and self-sufficiency/efficacy levels of such HD patients.