AUTHOR=Xia Guili , Huang Mei-juan , Chen Qing , Pu Yao , Dong Ling , Zeng Yiting , Wang Ling , Chen Yi-ping 

TITLE=Mediating role of social support between stigma and social alienation in patients with inflammatory bowel disease: a cross-sectional study

JOURNAL=Frontiers in Psychology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2025.1649317

DOI=10.3389/fpsyg.2025.1649317

ISSN=1664-1078

ABSTRACT=BackgroundStigma is a prevalent issue with well-documented negative consequences, including its association with social alienation. However, this relationship—and the mechanisms underlying it—remain underexplored in individuals with inflammatory bowel disease (IBD). This study aimed to examine the relationships among stigma, social support, and social alienation in IBD patients in China and to determine whether social support mediates the association between stigma and social alienation.MethodsIBD patients were recruited from two hospitals in China between July 10 and August 19, 2024, using convenience sampling. Data were collected using the Socio-demographic Questionnaire, the Social Impact Scale (SIS), the Social Support Rating Scale (SSRS), and the Generalized Social Alienation Scale (GSAS), which assessed participants’ demographic characteristics, perceived stigma, social support, and social alienation. Descriptive statistics, common method bias tests, analyses of variance, independent-samples t-tests, Pearson correlation analysis, and structural equation modeling were employed to analyze the data.ResultsA total of 504 participants were included, of whom 65.1% were male, with a mean age of 33.97 ± 9.28 years; 76.6% had been living with IBD for 2 years or more. Stigma was significantly negatively correlated with social support (r = −0.418, p < 0.01) and positively correlated with social alienation (r = 0.664, p < 0.01). Social support was also significantly negatively correlated with social alienation (r = −0.531, p < 0.01). Structural equation modeling showed that stigma negatively predicted social support (β = −0.487, p < 0.001) and positively predicted social alienation (β = 0.572, p < 0.001), while social support negatively predicted social alienation (β = −0.347, p < 0.001). Mediation analysis indicated that social support partially mediated the relationship between stigma and social alienation.ConclusionSocial support partially mediates the relationship between stigma and social alienation in IBD patients. Targeted interventions to reduce stigma and enhance social support may help mitigate social alienation and improve psychosocial outcomes in this population.