AUTHOR=Gilbertson Peter K. , Forrester Susan , Andrews Linda , McCann Kathleen , Rogers Lydia , Park Christina , Moye Jack TITLE=The National Children's Study Archive Model: A 3-Tier Framework for Dissemination of Data and Specimens for General Use and Secondary Analysis JOURNAL=Frontiers in Public Health VOLUME=Volume 9 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2021.526286 DOI=10.3389/fpubh.2021.526286 ISSN=2296-2565 ABSTRACT=The National Children’s Study (NCS) Archive was created as an information, data, and sample repository for the NCS Vanguard Study -- a longitudinal pregnancy and birth cohort designed to investigate the effects of environmental exposures on child health and development in the U.S. -- to provide qualified researchers with access to NCS data and samples. The National Children’s Study Archive (NCSA) model is a 3-tiered access model designed to make the wealth of information and materials gathered during the NCS Vanguard Study available at a user appropriate level. In accordance with the 2/26/2003 Final NIH Statement on Sharing Research Data (1) the NCSA model was developed as a 3-tier framework, for users of varying access levels, providing intuitive data exploration and visualization tools, an end-to-end data and sample request management system, and a restricted portal for participant-level data access with a team of experts available to assist users. This platform provides a model to accelerate transformation of information and materials from existing studies into new scientific discoveries.