AUTHOR=Zhou Ting , Guan Haijing , Wang Luying , Zhang Yao , Rui Mingjun , Ma Aixia 

TITLE=Health-Related Quality of Life in Patients With Different Diseases Measured With the EQ-5D-5L: A Systematic Review

JOURNAL=Frontiers in Public Health

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2021.675523

DOI=10.3389/fpubh.2021.675523

ISSN=2296-2565

ABSTRACT=Background
The EQ-5D-5L is a generic preference-based questionnaire developed by the EuroQol Group to measure health-related quality of life (HRQoL) in 2005. Since its development, it has been increasingly applied in populations with various diseases and has been found to have good reliability and sensitivity. This study aimed to summarize the health utility elicited from EQ-5D-5L for patients with different diseases in cross-sectional studies worldwide.
Methods
Web of Science, MEDLINE, EMBASE and the Cochrane Library were searched from 1st January 2012 to 31st October 2019. Cross-sectional studies reporting utility values measured with the EQ-5D-5L in patients with any specific disease were eligible. The language was limited to English. Reference lists of the retrieved studies were manually searched to identify more studies that met the inclusion criteria. Methodological quality was assessed with the Agency for Health Research and Quality (AHRQ) checklist. In addition, meta-analyses were performed. 
Results
In total, 9400 records were identified, and 98 studies met the inclusion criteria. In the included studies, 50 different diseases and 98,085 patients were analyzed. 35 studies were included in meta-analyses. The health utility ranged from 0.31 to 0.99 for diabetes mellitus (random effect model (REM): 0.83, (95%CI = 0.77-0.90); fixed effect model (FEM): 0.93 (95%CI = 0.93-0.93)); from 0.62 to 0.90 for neoplasms (REM: 0.75 (95%CI = 0.68-0.82); FEM: 0.80 (95%CI = 0.78-0.81)); from 0.56 to 0.85 for cardiovascular disease (REM: 0.77 (95%CI = 0.75-0.79) ; FEM: 0.76 (95%CI = 0.75-0.76)); from 0.31 to 0.78 for multiple sclerosis (REM: 0.56 (95%CI = 0.47-0.66); FEM: 0.67 (95%CI = 0.66-0.68)); from 0.68 to 0.79 for chronic obstructive pulmonary disease (REM: 0.75 (95%CI = 0.71-0.80); FEM: 0.76 (95%CI = 0.75-0.77)) from 0.65 to 0.90 for HIV infection (REM: 0.84 (95%CI = 0.80-0.88); FEM: 0.81 (95%CI = 0.80-0.82)); from 0.37 to 0.89 for chronic kidney disease (REM: 0.70 (95%CI = 0.48-0.92; FEM: 0.76 (95%CI = 0.74-0.78)). 
Conclusions
EQ-5D-5L is one of the most widely used preference-based measures of HRQoL in patients with different disease worldwide. The variation of utility values for the same disease were influenced by the characteristics of patients, living environment and EQ-5D-5L value set.