AUTHOR=Marco Alejandra , Pazos-Couselo Marcos , Moreno-Fernandez Jesús , Díez-Fernández Ana , Alonso-Sampedro Manuela , Fernández-Merino Carmen , Gonzalez-Quintela Arturo , Gude Francisco 

TITLE=Time above range for predicting the development of type 2 diabetes

JOURNAL=Frontiers in Public Health

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.1005513

DOI=10.3389/fpubh.2022.1005513

ISSN=2296-2565

ABSTRACT=Aim: To investigate the prognostic value of time range metrics, as measured by continuous glucose monitoring, with respect to the development of type 2 diabetes.
Research Design and Methods: A total of 499 persons without diabetes from the general population were followed-up for 5 years. Time range metrics were measured at the start and medical records were checked over the period study.
Results: Twenty-two subjects (8.3 per 1000 person-years) developed type 2 diabetes.  After adjusting for age, gender, family history of diabetes, body mass index and glycated hemoglobin concentration, multivariate analysis revealed 'time above range' (TAR, i.e., with a plasma glucose concentration of >140 mg/dL) to be significantly associated with a greater risk (OR=1.06, CI 1.01-1.11) of developing diabetes (AUC=0.94, Brier=0.035).
Conclusions: Time above range provides additional information to that offered by glycated hemoglobin to identify patients at a higher risk of developing type 2 diabetes in a population-based study.