AUTHOR=Chen Huijing , Zhou Zhihua , Li Zhenglong , Liang Shanshan , Zhou Jingjing , Zou Guanyang , Zhou Shangcheng 

TITLE=Time trends in the burden of stroke and subtypes attributable to PM2.5 in China from 1990 to 2019

JOURNAL=Frontiers in Public Health

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.1026870

DOI=10.3389/fpubh.2022.1026870

ISSN=2296-2565

ABSTRACT=Abstract
Background: Increasing studies have found that PM2.5 has large adverse effects on stroke mortality. We want to investigate the long-term trends in the mortality of stroke attributable to ambient particulate matter pollution exposure (APE) and household air pollution exposure (HPE) to provide evidence facilitating the design of policy.
Methods: The deaths data of stroke and its subtypes attributable to PM2.5 were obtained from the Global Burden of Disease (GBD) 2019, analyzed by Joinpoint regression software and the age-period-cohort (APC) method to assess the magnitude of the trends in mortality and the temporal trends in the mortality rate by age, period, and cohort.
Results: From 1990 to 2019, the age-standardized mortality rate (ASMR) attributable to PM2.5 exposure trended downwards, but the trends of APE and HPE were opposite. The trends varied among subtypes, the AAPC of intracerebral hemorrhage, ischemic stroke, and subarachnoid hemorrhage attributable to PM2.5 were 0.7%, 2.5%, and -3.3% respectively. The longitudinal age curve of the APC model showed that the mortality rates due to PM2.5 exposure increased with age. The period RRs of ischemic stroke due to APE increased significantly. The cohort RRs of APE increased among those born from 1905 to 1990. The net drifts of all subtypes attributable to PM2.5 were below 0, but owing to the increase of APE, the range of the decline was small. Males had higher net drift values, compared with females.
Conclusions: APE has become the main type of PM2.5 leading to stroke in China. PM2.5 exposure is more harmful to ischemic stroke, males, and elderly. Chinese government should pay attention to the long-term impact of ambient air pollution on stroke and take effective public health policies and interventions.