AUTHOR=Liu Shelan , Zhu An , Pan Jinren , Ying Lihong , Sun Wanwan , Wu Hanting , Zhu Haiying , Lou Haiyan , Wang Lan , Qin Shuwen , Yu Zhao , Cai Jian , Chen Yin , Chen Enfu 

TITLE=The clinical and virological features of two children's coinfections with human adenovirus type 7 and human coronavirus-229E virus

JOURNAL=Frontiers in Public Health

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.1048108

DOI=10.3389/fpubh.2022.1048108

ISSN=2296-2565

ABSTRACT=Objective: Human adenovirus (HAdV) coinfection with other respiratory viruses is common, but adenovirus infection mixed with HCoV-229E is very rare. 
Study Design and Setting: Clinical manifestations, laboratory examinations, and disease severity were compared between the HAdV coinfected with HCoV-229E, mono-adenovirus, and mono-HCoV-229E groups.
Results: Among 24 hospitalized children, two with HAdV-Ad7 coinfection with HCoV-229E and 21 with a single adenovirus infection were identified from July to August 2019. Additionally, three adult asymptotic cases with HCoV-229E were also screened. No significant difference in age was found in the coinfection and mono-adenovirus groups (11 years vs. 8 years, p = 0.332). Both groups had the same incubation (2.5 days vs. 3 days, p = 0.8302), fever durations (2.5 days vs. 2.9 days, p = 0.5062), and the hospital stays (7 days vs. 6.76 days, p = 0.640). No obvious differences were found in viral loads in the coinfection and single adenovirus group (25.4 vs. 23.7, p = 0.570), in the coinfection and single HCoV-229E group (32.9 vs. 30.06, p = 0.067). All cases were discharged completely.
Conclusion: HAdV-Ad7 coinfected with HCoV-229E in healthy children may not increase the clinical severity and prolong the clinical course. The specific interaction mechanism between the viruses still needs further study.