AUTHOR=Lv Linlin , Zhao Binggong , Kang Jie , Li Shujing , Wu Huijian TITLE=Trend of disease burden and risk factors of breast cancer in developing countries and territories, from 1990 to 2019: Results from the Global Burden of Disease Study 2019 JOURNAL=Frontiers in Public Health VOLUME=Volume 10 - 2022 YEAR=2023 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.1078191 DOI=10.3389/fpubh.2022.1078191 ISSN=2296-2565 ABSTRACT=Background: The incidence, mortality, disability-adjusted life year (DALY) burden and attributable risk factors of breast cancer vary greatly by country and region, especially between developing countries and developed countries. Here, this study was aimed to analyze the trend of breast cancer development in developing countries based on the impact of different social development indices (SDI) and World Bank income levels disease data from 1990 to 2019. Methods: Data obtained from the 2019 Global Burden of Disease (GBD) study on annual incidence, death, DALY, YLL, YLD and their age standardized rate (ASR) of breast cancer from 1990 to 2019 in different countries and territories. We also analyzed the general risk factors by comparative risk assessment framework (CRA). Result: The global ASIR is gradually increased from 21.44 per 100,000 population in 1990 to 24.17 per 100,000 persons in 2019. Among countries with middle SDIs and low middle SDIs, it rose precipitously (2.91-fold and 2.49-fold, respectively). The ASIR of breast cancer is increased in world bank lower middle income (EAPC of 0.29 [95% UI: 0.20 to 0.37] and low income (EAPC of 0.59 [95% UI: 0.53 to 0.65]. Solomon Islands and United Arab Emirates had an increase of the greatest magnitude in breast cancer death cases. Compared to 1990, the percent change increased separately 1169% and 851%. Compared with developed areas, breast cancer-related deaths increased rapidly in developing regions, especially among the middle-aged and the elderly. Meanwhile it constituted an ever-expanding long-term burden of breast cancer. Among all GBD regions, the age distribution of Oceania was the youngest. The deaths of young and middle-aged groups accounted for 69% of in 1990 and 72% in 2019. The percent changes in deaths due to the seven risk factors in low- to middle-SDI regions increased significantly over time in all age groups. However, the diet high red meat and high BMI were the largest magnitudes of increases. Conclusion: In low- and medium-income countries, public health policy regarding breast cancer is particularly important. The development and adoption of cost-effective screening and therapeutic solutions, taking steps to mitigate risk factors and the establishment of cancer infrastructure is essential.